Search results for "artificial intelligence"
showing 10 items of 6122 documents
A convolutional neural network for virtual screening of molecular fingerprints
2019
In the last few years, Deep Learning (DL) gained more and more impact on drug design because it allows a huge increase of the prediction accuracy in many stages of such a complex process. In this paper a Virtual Screening (VS) procedure based on Convolutional Neural Networks (CNN) is presented, that is aimed at classifying a set of candidate compounds as regards their biological activity on a particular target protein. The model has been trained on a dataset of active/inactive compounds with respect to the Cyclin-Dependent Kinase 1 (CDK1) a very important protein family, which is heavily involved in regulating the cell cycle. One qualifying point of the proposed approach is the use of molec…
On Metadata Support for Integrating Evolving Heterogeneous Data Sources
2019
With the emergence of big data technologies, the problem of structure evolution of integrated heterogeneous data sources has become extremely topical due to dynamic and diverse nature of big data. To solve the big data evolution problem, we propose an architecture that allows to store and process structured and unstructured data at different levels of detail, analyze them using OLAP capabilities and semi-automatically manage changes in requirements and data expansion. In this paper, we concentrate on the metadata essential for the operation of the proposed architecture. We propose a metadata model to describe schemata and supplementary properties of data sets extracted from sources and tran…
Are Neural Networks Imitations of Mind?
2015
Artificial neural networks are often understood as a good way to imitate mind through the web structure of neurons in brain, but the very high complexity of human brain prevents to consider neural networks as good models for human mind;anyway neural networks are good devices for computation in parallel. The difference between feed-forward and feedback neural networks is introduced; the Hopfield network and the multi-layers Perceptron are discussed. In a very weak isomorphism (not similitude) between brain and neural networks, an artificial form of short term memory and of acknowledgement, in Elman neural networks, is proposed.
Memetic algorithms and memetic computing optimization: A literature review
2012
Abstract Memetic computing is a subject in computer science which considers complex structures such as the combination of simple agents and memes, whose evolutionary interactions lead to intelligent complexes capable of problem-solving. The founding cornerstone of this subject has been the concept of memetic algorithms, that is a class of optimization algorithms whose structure is characterized by an evolutionary framework and a list of local search components. This article presents a broad literature review on this subject focused on optimization problems. Several classes of optimization problems, such as discrete, continuous, constrained, multi-objective and characterized by uncertainties…
Interactive Effects of Explicit Emergent Structure: A Major Challenge for Cognitive Computational Modeling
2015
International audience; David Marr's (1982) three-level analysis of computational cognition argues for three distinct levels of cognitive information processingnamely, the computational, representational, and implementational levels. But Marr's levels areand were meant to bedescriptive, rather than interactive and dynamic. For this reason, we suggest that, had Marr been writing today, he might well have gone even farther in his analysis, including the emergence of structurein particular, explicit structure at the conceptual levelfrom lower levels, and the effect of explicit emergent structures on the level (or levels) that gave rise to them. The message is that today's cognitive scientists …
A stigmergic approach for social interaction design in collaboration engineering
2014
The increasing number of available collaborative tools and their extensive use in many organizational activities has constantly raised the complexity of collaboration engineering. It presumes the design of group decision processes, supported by a wide-range of groupware tools, in an ill-structured, dynamic, and open environment. As many of these processes are recurring by nature, the development of a shared repository to store the collective knowledge and experiences of group decision process designs became a core research topic of collaboration engineering in last few years. The paper presents a human-computer interaction engineering approach to design a software prototype that provides pe…
A computational model for motor learning in insects
2013
The aim of this paper is to propose a computational model, inspired by Drosophila melanogaster, able to handle problems related to motor learning. The role of the Mushroom Bodies and the Central Complex in solving this problem is analyzed and plausible biologically inspired models are proposed. The designed computational models have been evaluated in simulation using a dynamic structure inspired by the fruit fly. The obtained results open the way to new neurobiological experiments focused to better understand the underlined mechanisms involved, to verify the feasibility of the hypotheses formulated and the significance of the obtained results.
Voltage Security Assessment by Using PFDT and CBR Methods in Emerging Power System
2018
Abstract This paper exhibits varied methods for voltage security assessment in a restructured power system. This paper primarily lays emphasis on two methods that are Probabilistic Fuzzy Decision Tree (PFDT) and Case Based Reasoning (CBR). In PFDT, Decision Tree plays an integral role for classification of system. For further classification of power system security, an algorithm is developed to categorise the buses which trouble the security most. After classification of system, by using minimum amount of load curtailment of voltages on buses which made insecure to secure load. Optimization of load is done by curtailing reactive power from insecure buses. In CBR, old cases from database are…
A probabilistic expert system for predicting the risk of Legionella in evaporative installations
2011
Research highlights? The bacterium Legionella usually lives in water sources such as cooling towers. ? We discuss a probabilistic expert system for predicting the risk of Legionella. ? The expert system has a master-slave architecture. ? The inference engine is implemented through Bayesian reasoning. ? Bayesian networks model and connect relationships for chemical and physical variables. Early detection in water evaporative installations is one of the keys to fighting against the bacterium Legionella, the main cause of Legionnaire's disease. This paper discusses the general structure, elements and operation of a probabilistic expert system capable of predicting the risk of Legionella in rea…
The Insect Mushroom Bodies: a Paradigm of Neural Reuse
2013
This paper is devoted to discuss the implementation of models,which are inspired by the fly Drosophila melanogaster and able to handle open problems in the field of robotics such as attention, expectation and sequence learning. The role of the Mushroom Bodies (MBs) in solving these tasks is analyzed in detail and a unifying plausible biologically inspired model is proposed. The developed neural structure is able to show different capabilities in line with the paradigm of neural reuse. The same neural circuit can be exploited to accomplish multiple tasks showing interesting capabilities such as attention, expectation and delayed match-to-sample. The simulation results here reported suggest a…