Search results for "arvo"
showing 10 items of 2138 documents
Activation of the human immune system via toll-like receptors by the oncolytic parvovirus H-1.
2012
This study aimed to investigate the function of toll-like receptors (TLRs) during oncolytic parvovirus H-1 (H-1PV)-induced human immune responses. First, the role of TLRs in the activation of the NFκB transcription factor was characterized; second, the immunologic effects of H-1PV-induced tumor cell lysates (TCL) on human antitumor immune responses were evaluated. A human ex vivo model was used to study immune responses with dendritic cells (DCs). Human embryonic kidney cells (HEK293) transfected to stably express TLRs were used as potential human DC equivalents to further investigate the role of specific TLRs during immune activation. TLR3 and TLR9 were activated by H-1PV infection, which …
Parvovirus B19 nonstructural protein-induced damage of cellular DNA and resultant apoptosis.
2010
Parvovirus B19 is a widespread virus with diverse clinical presentations. The viral nonstructural protein, NS1, binds to and cleaves the viral genome, and induces apoptosis when transfected into nonpermissive cells, such as hepatocytes. We hypothesized that the cytotoxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, we found that NS1 covalently binds to cellular DNA and is modified by PARP, an enzyme involved in repairing single-stranded DNA nicks. We furthermore discovered that the DNA nick repair pathway initiated by poly(ADPribose)polymerase and the DNA repair pathways initiated by …
Lydia Davis: Kafka valmistaa päivällistä
2021
Kirja-arvostelu teoksesta Lydia Davis: Kafka valmistaa päivällistä. Valitut novellit. Valikoinut ja suomentanut Aki Salmela. Siltala/Sanavalinta 2021. 356 s. nonPeerReviewed
Immanente Kritik und soziales Leben. Selbsttransformative Praxis nach Hegel und Dewey
2020
Sitoutuminen kasvamiseen yksilönä, yhteiskunnassa ja yhteisöissä
2009
Shadows under the North Star- The inequality developing in Finnish school education
2018
In Finland, the National Core Curriculum for Basic Education is supposed to ensure equal opportunity for enrollment to upper secondary education by defining the learning objectives for each school subject at the end of basic education. The first nine years of education in Finland are described locally as ‘basic education’. Having equal learning opportunity as the leading ideal of educational equity implies that no statistically significant differences should prevail between groups, such as genders or regions. This study sets out to map the fulfilment of equality via two research questions: How do learning outcomes at the end of basic education vary across certain background variables in thr…
Unravelling conceptualizations of (in)equality in early childhood education and care system
2018
Early childhood education’s role in increasing equality in society has been highlighted by international organizations. However, it is unclear what is meant by the concept of equality in different situations, as the meaning fluctuates and reflects the cultural political contexts in which it is embedded. In this paper, we analyse the equality discourses of local early childhood education and care (ECEC) policymakers in Finland, drawing on different conceptualizations of equality and social justice. In doing so, we show that the way in which equality is conceptualized differs – along with the suggested remedies – depending on whether the subjects of equality are adults, children at the border…
Social Protection, Economic Growth and Social Change : Goals, Issues and Trajectories in China, India, Brazil and South Africa. [Book Review]
2016
In the past, social protection was lauded as a viable nationalistic movement with very few countries adopting it. However, as more countries adopted this system at the beginning of the twenty-first...
Gender-specific Call of Duty: A Note on the Neglect of Conscription in Gender Equality Indices
2022
We document that existing gender equality indices do not account for gender-specific mandatory peace-time conscription (compulsory military service). This suggests that gender-specific conscription is not considered to be an important gender issue. If an indicator measuring the gender equality of mandatory conscription was to be included in gender equality indices with appropriate weight, then the relative rankings of countries in terms of measured gender equality could be affected. In the context of the Nordic countries, this would mean that Finland and Denmark – the countries with mandatory conscription for men only – would have worse scores with respect to gender equality compared to Swe…
On the stability of stablecoins
2021
This paper investigates the volatility processes of stablecoins and their potential stochastic interdependencies with Bitcoin volatility. We employ a novel approach to choose the optimal combination for the power law exponent and the minimum value for the volatilities bending the power law. Our results indicate that Bitcoin volatility is well-behaved in a statistical sense with a finite theoretical variance. Surprisingly, the volatilities of stablecoins are statistically unstable and contemporaneously respond to Bitcoin volatility. Also, whereas the volatilities of stablecoins are not Granger-causal for Bitcoin volatility, lagged Bitcoin volatility exhibits Granger-causal effects on the vol…