Search results for "ash"
showing 10 items of 1718 documents
Reciprocal translocation t(1;18)(p32;q21) in a patient with some phenotypical anomalies
1987
The authors report on a case of 1;18 translocation and request contact with any colleagues who have observed similar cases.
MetaCache-GPU: Ultra-Fast Metagenomic Classification
2021
The cost of DNA sequencing has dropped exponentially over the past decade, making genomic data accessible to a growing number of scientists. In bioinformatics, localization of short DNA sequences (reads) within large genomic sequences is commonly facilitated by constructing index data structures which allow for efficient querying of substrings. Recent metagenomic classification pipelines annotate reads with taxonomic labels by analyzing their $k$-mer histograms with respect to a reference genome database. CPU-based index construction is often performed in a preprocessing phase due to the relatively high cost of building irregular data structures such as hash maps. However, the rapidly growi…
PSD3 downregulation confers protection against fatty liver disease
2022
Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cell…
Alteration effects of volcanic ash in seawater: Anomalous Y/Ho ratios in coastal waters of the Central Mediterranean sea
2007
This paper presents the results of a study based on data collected during the oceanographic cruise ANSIC 2001 carried out in the Ionian Sea during the explosive activity of Mount Etna in the summer of 2001. Anomalous low values of Y/Ho ratios in seawater suggest extensive scavenging processes on the surfaces of smectitic alteration products, with Y and Ho fractionation controlled by the differences in their electronic configurations and behaviour during solution/surface complexation equilibria. These processes can also be traced through the presence of significant tetrad effects recorded in the chondrite-normalised Rare Earth Elements and Yttrium (YREEs) patterns of suspended particulate ma…
Flash-flooding of Ephemeral Streams in the Context of Climate Change
2021
Ephemeral streams, which are more extended than expected, entail a significant flood risk. Historically they have been underestimated due to their intermittent flow and the lack of knowledge on their hydro-geomorphology. Currently, European legislation recognizes their associated risk and supports research into them, adapting the scale and methodology to their characteristics. Based on the compilation of various works carried out in four Valencian catchments (Eastern Spain), this paper approaches the key questions of rainfall-runoff conversion and flood generation in ephemeral streams, taking into account their hydro-geomorphological specificity. Moreover, the consequences which derive from…
Pollen and Plant Macroremain Analyses for the Reconstruction of Environmental Changes in the Early Metal Period
2006
A sharp increase in human population density and the same time fundamental changes in the location of settlement, moving away from earlier inhabited places points to significant changes in the environment. This period with a sharp decrease in anthropogenic indicators and poor records of slash and burn cultivation and field crop-growing is named “transition” period (Vasks et.al.1998) and indicates the lack of stable and continuous inhabitant sites. This phenomena can be explained by the small size of settlements at the Early Iron Age, expressed by a weak cultural layer and these could be defined as separate farmsteads. Modern farming practices, especially modern tillage, adversely affected t…
Menopausal syndrome limited to hot flushes and sweating a representative survey study.
2017
The menopausal syndrome is described as a series of various physical and nonphysical symptoms attributed to perimenopausal changes in hormone levels. However, evidence is biased by focusing research on the target group of middle aged women only. To overcome this bias, we examined the occurrence of menopausal symptoms during the entire life span in both women and men.Therefore, we studied the occurrence of menopausal symptoms with the widely used Menopause Rating Scale (MRS) across the entire life span in both women and men. To this end, we performed a nationwide cross-sectional survey study in Germany in which we examined a representative sample of 2527 persons aged from 14 to 95 years. Add…
Functional data analysis for optimizing strategies of cash flow management
2015
The cash management deals with problem of automating and managing cash flow processes. Optimization of the management processes greatly reduces overall cash handling costs. The present analysis is an empirical study of cash flows, from and to bank branches, deriving an underlying theoretical framework, which can in a reasonable way be connected with the optimal strategy. Functional data analysis is considered an appropriate framework to analyse the dynamics of the time series behavior of cash flows: since the observations are not equally spaced in time and their number is different for each series, they are converted in a collection of random curves in a space spanned by finite dimensional …
Developments in financial information by local entities in europe
2010
In recent years, most Organisation for Economic and Cooperation Development (OECD) countries have brought in important reforms into their public accounting systems with the objective of both improving public service management and increasing the transparency and accountability of governments. Reforms of government accounting share a common direction towards the implementation of accrual-based accounting systems. In this context, this paper presents the situation of local government accounting systems in European countries with the aim of showing the degree of uniformity/ heterogeneity that currently exists among the countries considered and why differences persist nowadays, trying to classi…
The Application of the IPSAS in Spain
2021
Governmental accounting was adapted to IPSAS in Spain in 2010, following the reform in the business accounting system to adapt it to IFRS. However, the budget maintains the modified cash criteria and there is an integrated system that includes financial and budgeting accounting. This chapter analyses the normative process and the main challenges and benefits that the new system has had at the three levels of government: central, regional, and local. In order to understand the experience of practitioners, a survey for accountants and financial directors has been carried out at each government level. The results show that budgetary reporting is considered still more useful than accrual financ…