Search results for "assembly"
showing 10 items of 768 documents
Multicomponent polymeric micelles based on polyaspartamide as tunable fluorescent pH-window biosensors
2010
Abstract PHEA-PEG 5000 -C 16 is a polyaspartamide polymer with appended hydrophilic PEG 5000 functions and hydrophobic n-C 16 units forming biocompatible micelles with a CAC as low as 1.8 × 10 −7 M. The protonation and acidity constants of the polymer's amino and carboxylic groups have been determined by potentiometric titrations at five different concentrations higher than CAC, finding concentration-independent values. Viscosity and polarity of the micellar core have been investigated by means of fluorescent probes, finding local values comparable to those of pure toluene and to the core of sodium dodecyl sulphate micelles, independently on the protonation degree of the polymer. The fluor…
Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers.
2018
In protein or peptide chemistry, thiols are frequently chosen as a chemical entity for chemoselective modification reactions. Although it is a well-established methodology to address cysteines and homocysteines in aqueous media to form S-C bonds, possibilities for the chemoselective formation of asymmetric disulfides have been less approached. Focusing on bioreversibility in conjugation chemistry, the formation of disulfide bonds is highly desirable for the attachment of thiol-containing bioactive agents to proteins or in cross-linking reactions, because disulfide bonds can combine stability in blood with degradability inside cells. In this Concept article, recent approaches in the field of…
Scientific and technological approaches for sintering and joining of metallic materials by SPS
2013
The flash sintering technique (commonly known as spark plasma sintering, SPS) generates a craze worldwide. This process allows a powder densification from speeds generally 10 to 100 times higher than those of the traditional sintering techniques. In addition, this allows the synthesis of innovative and original dense materials, with a controlled microstructure, complex shapes and, sometimes large sizes. However, the control of scaling and microstructure homogeneity of parts obtained by such a process requires a perfect knowledge of technical equipment including flash sintering to reduce thermal gradients. Modeling is a valuable aid to achieve the improvement of its control. Another potentia…
Self-Assembly-Directed Organization of a Fullerene–Bisporphyrin into Supramolecular Giant Donut Structures for Excited-State Charge Stabilization
2021
Functional materials composed of spontaneously self-assembled electron donor and acceptor entities capable of generating long-lived charge-separated states upon photoillumination are in great demand as they are key in building the next generation of light energy harvesting devices. However, creating such well-defined architectures is challenging due to the intricate molecular design, multistep synthesis, and issues associated in demonstrating long-lived electron transfer. In this study, we have accomplished these tasks and report the synthesis of a new fullerene–bis-Zn-porphyrin e-bisadduct by tether-directed functionalization of C60 via a multistep synthetic protocol. Supramolecular oligom…
Substrate templating guides the photoinduced reaction of C60on calcite
2014
cited By 7; International audience; A substrate-guided photochemical reaction of C60 fullerenes on calcite, a bulk insulator, investigated by non-contact atomic force microscopy is presented. The success of the covalent linkage is evident from a shortening of the intermolecular distances, which is clearly expressed by the disappearance of the moiré pattern. Furthermore, UV/Vis spectroscopy and mass spectrometry measurements carried out on thick films demonstrate the ability of our setup for initiating the photoinduced reaction. The irradiation of C60 results in well-oriented covalently linked domains. The orientation of these domains is dictated by the lattice dimensions of the underlying c…
Fonctionnalisation et métallisation des diamantoïdes
2015
The thesis deals with development of synthetic methods for preparation of novel carbon-metal organohybrid based on diamondoid and palladium. The vapor pressure of various diamondoids was measured from a new measurement protocol at solid-vapor thermodynamic equilibrium state. Their volatile tendency opened a possibility to do deposition from gas phase and at various pressure (ambient, primary vacuum, and high vacuum) of diamondoids on silicon or mica substrates. SEM observations have shown that depending on the type of functional groups on the diamondoid, different crystal shapes can be produced (rods, needles, triangles, truncated octahedral form).OMCVD of palladium on functionalized diaman…
Thermo-mechanical analysis of irradiation swelling and design optimization of the IFMIF target assembly with bayonet backplate
2017
Abstract The availability of a high flux neutron source for testing candidate materials under irradiation conditions, which will be typically encountered in future fusion power reactors (ITER, DEMO, FPR), is a fundamental step towards the development of fusion energy. To this purpose, the International Fusion Materials Irradiation Facility (IFMIF) represents the reference option to provide the fusion community with a DEMO-relevant neutron source capable of irradiating samples at a damage rate of up to 20 dpa/fpy (in steel) in a volume of 0.5 l. In the framework of the engineering design activities of IFMIF, ENEA is committed in the design of the lithium target assembly (TA) with removable (…
Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay
2013
Curcumin and trans-resveratrol are well-known antioxidant polyphenols with radiomodulatory properties, radioprotecting non-cancerous cells while radiosensitizing tumor cells. This dual action may be the result of their radical scavenging properties and their effects on cell-cycle checkpoints that are activated in response to radiation-induced chromosomal damage. It could be also caused by their effect on regulatory pathways with impact on detoxification enzymes, the up-regulation of endogenous protective systems, and cell-cycle-dependent processes of DNA damage. This work aims to elucidate the mechanisms underlying the dual action of these polyphenols and investigates under which conditions…
Astacins: proteases in development and tissue differentiation
2013
Capítulo en: Stöker, Walter; Brix, Klaudia (eds.). Proteases: structure and function. Wien: Springer, 2013
The Gelling Ability of Some Diimidazolium Salts: Effect of Isomeric Substitution of the Cation and Anion
2013
The gelling ability of some geminal imidazolium salts was investigated both in organic solvents and in water solution. Organic salts differing either in the cation or anion structure were taken into account. In particular, the effects on the gel-phase formation of isomeric substitution on the cation or anion as well as of the use of mono- or dianions were evaluated. As far as the cation structure is concerned, isomeric cations, such as 3,3′-di-n-octyl-1,1′-(1,4-phenylenedimethylene)diimidazolium and 3,3′-di-n-octyl-1,1′-(1,3-phenylenedimethylene)diimidazolium, were used. On the other hand, in addition to the bromide anion, isomeric dianions, such as the 1,5- and 2,6-naphthalenedisulfonate a…