Search results for "autophagie"
showing 3 items of 3 documents
Resveratrol-induced xenophagy promotes intracellular bacteria clearance in intestinal epithelial cells and macrophages
2019
International audience; Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be bene ficial. Here, we show that resveratrol is able to boost xenophagy, a selective form of autophagy that target invasive bacteria. We demonstrated that resveratrol promotes in vitro autophagy-dependent clearance of intracellular bacteria in intestinal epithelial cells and macrophages. These results were validated in vivo using infection in a transgenic GFP-LC3 zebra f…
Lipid and homeostatic alterations in nervous tissues associated with aging and metabolic dysregulations: implication of gut microbiota and autophagy
2020
The retina and the brain are two nervous tissues rich in lipids. Aging and metabolic syndrome (MetS) are associated with functional and physiological alterations of these tissues as well as modifications in the composition of the gut microbiota. The global objective of this thesis work is to understand the lipid and homeostatic alterations in aging and MetS contexts in the retina and the brain. In a first study, we evaluated the impact of the modifications in the composition of the gut microbiota associated with aging on the lipid/fatty acid contents of the liver and the brain (cortex). We showed that colonization of germ-free mice with the gut microbiota of old mice modulated the hepatic e…
Le corps contre lui-même : imaginaire de l’autodestruction dans l’œuvre poétique et dramatique de Homero Aridjis
2020
International audience; Dans nos sociétés du spectacle, le corps est à la fois objet d’exhibition, de désir et de consommation. Les messages et injonctions sont envahis par un imaginaire du corps triomphant : il se doit d’être beau, fort, sain, puissant, flexible, tonique, sexy… Face à ce canon à images normatives, la littérature est peut-être l’espace où peut se déployer un contre-imaginaire du corps. Boulimie, mutilation, autodestruction, « consommation de soi » sont ainsi des images fréquentes dans les projections littéraires. Au sommet de cet imaginaire de la diminution de soi : l’autophagie, pulsion contradictoire par laquelle le corps se dévore lui-même. Ce sont ces gestes autodestruc…