Search results for "back"

showing 10 items of 2078 documents

Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants

2019

Purpose: To assess the contribution of rare variants in the genetic background toward variability of neurodevelopmental phenotypes in individuals with rare copy-number variants (CNVs) and gene-disruptive variants. Methods: We analyzed quantitative clinical information, exome sequencing, and microarray data from 757 probands and 233 parents and siblings who carry disease-associated variants. Results: The number of rare likely deleterious variants in functionally intolerant genes (“other hits”) correlated with expression of neurodevelopmental phenotypes in probands with 16p12.1 deletion (n=23, p=0.004) and in autism probands carrying gene-disruptive variants (n=184, p=0.03) compared with thei…

MaleParents0301 basic medicineProbandNeuronalGenetic Carrier Screening16p11.2 deletion030105 genetics & heredityCognitionFamily historyNeural Cell Adhesion MoleculesGenetics (clinical)Exome sequencingSequence DeletionGeneticsGenetic Carrier ScreeningPhenotypePenetrancePedigreePhenotypeAutistic Disorder/genetics; Autistic Disorder/physiopathology; Cell Adhesion Molecules Neuronal/genetics; Chromosomes Human Pair 16/genetics; Cognition/physiology; DNA Copy Number Variations/genetics; Female; Gene Expression Regulation/genetics; Genetic Background; Genetic Carrier Screening; Humans; Male; Methyltransferases/genetics; Nerve Tissue Proteins/genetics; Parents; Pedigree; Phenotype; Proteins/genetics; Sequence Deletion/genetics; Siblings; 16p11.2 deletion; CNV; autism; modifier; phenotypic variabilityFemaleGenetic BackgroundHumanDNA Copy Number VariationsCell Adhesion Molecules NeuronalCNVautismNerve Tissue ProteinsBiologyChromosomesArticle03 medical and health sciencesmental disordersmedicineHumansAutistic DisorderBiologyGenemodifierPair 16SiblingsCalcium-Binding ProteinsProteinsMethyltransferasesmedicine.disease16p11.2 deletion; autism; CNV; modifier; phenotypic variability; Genetics (clinical)Cytoskeletal Proteins030104 developmental biologyGene Expression Regulation[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human geneticsAutismphenotypic variabilityHuman medicine16p11.2 deletion; autism; CNV; modifier; phenotypic variability; Autistic Disorder; Cell Adhesion Molecules Neuronal; Chromosomes Human Pair 16; Cognition; DNA Copy Number Variations; Female; Gene Expression Regulation; Genetic Background; Humans; Male; Methyltransferases; Nerve Tissue Proteins; Parents; Pedigree; Phenotype; Proteins; Sequence Deletion; Siblings; Genetic Carrier ScreeningCell Adhesion MoleculesChromosomes Human Pair 16Transcription FactorsGenetics in Medicine
researchProduct

Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?

2018

Background: Exposure to radiofrequency electromagnetic fields (RF-EMF) from mobile communication technologies is changing rapidly. To characterize sources and associated variability, we studied the differences and correlations in exposure patterns between children aged 8 to 18 and their parents, over the course of the day, by age, by activity pattern, and for different metrics of exposure. Methods: Using portable RF-EMF measurement devices, we collected simultaneous real-time personal measurements of RF-EMF over 24 to 72 h in 294 parent-child pairs from Denmark, the Netherlands, Slovenia, Switzerland, and Spain. The devices measured the power flux density (mW/m(2)) in 16 different frequency…

MaleParentsGeneration gapWireless technologyRadio Wavesescuelashumanosadolescente010501 environmental sciences01 natural sciencesSmart phones0302 clinical medicineTelecommunications linkBackground exposureCordless phoneMedicine030212 general & internal medicineChildWorkplacemediana edadlcsh:Environmental sciencesGeneral Environmental Sciencelcsh:GE1-350TravelSchoolsadultoMiddle Aged3. Good healthadulto jovenEuropeondas de radioIntergenerational RelationsFemalePower fluxAdultEveningAdolescentCell phonespadres03 medical and health sciencesYoung Adultrelaciones intergeneracionalescampos electromagnéticosHumans0105 earth and related environmental sciencesbusiness.industryDigital Enhanced Cordless TelecommunicationsElectromagnetic fieldsEnvironmental ExposurePersonal exposureHousingexposición ambientalbusinessviajeCell PhoneDemography
researchProduct

Incidence and Clinical Impact of Recurrent Takotsubo Syndrome: Results From the GEIST Registry

2019

Background Current literature only reports variable information from single‐center studies on the recurrence rate, the complications, and the outcome of patients with Takotsubo syndrome ( TTS) experiencing recurrent TTS . Therefore, a detailed description of clinical characteristics, predictors, and the prognostic impact of patients with TTS and recurrences in a multicenter registry is needed. Methods and Results We analyzed 749 patients with TTS from 9 European centers being part of the international, multicenter GEIST (German Italian Stress Cardiomyopathy) Registry. Patients were divided into the recurrence group and the nonrecurrence group. The recurrence rate at a median follow‐up of 8…

MalePediatricsmedicine.medical_specialtyrecurrenceCardiomyopathyVentricular Dysfunction RightShock Cardiogenic030204 cardiovascular system & hematology03 medical and health sciencesVentricular Dysfunction Left0302 clinical medicineTakotsubo CardiomyopathyGermanyThromboembolismMedicineHumans030212 general & internal medicineHospital MortalityRegistriesOriginal ResearchAgedProportional Hazards ModelsHeart FailureAged 80 and overTakotsubo syndromebusiness.industryIncidence (epidemiology)IncidenceStroke VolumeMiddle Agedmedicine.diseaseStrokeItalyBackground currentHeart failureHypertensionFemaleCardiology and Cardiovascular MedicinebusinessJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
researchProduct

The standing knee lift test is not a useful screening tool for time loss from low back pain in youth basketball and floorball players

2021

Abstract Objectives The aim of this study was to investigate the association between pelvic kinematics during the standing knee lift (SKL) test and low back pain (LBP) in youth floorball and basketball players. Design A prospective cohort study. Setting Finnish elite youth floorball and basketball players. Participants Finnish elite youth female and male floorball and basketball players (n = 258, mean age 15.7 ± 1.8). Main outcome measures LBP resulting in time loss from practice and games was recorded over a 12-month period and verified by a study physician. Associations between LBP and sagittal plane pelvic tilt and frontal plane pelvic obliquity during the SKL test as measured at baselin…

MalePelvic tiltmedicine.medical_specialtyBasketballAdolescentlantioalaselkäPhysical Therapy Sports Therapy and RehabilitationBasketballPelvis03 medical and health sciences0302 clinical medicinenuoretRisk FactorsselkäsairaudetmedicineHumansrisk factorsOrthopedics and Sports MedicineProspective StudiesProspective cohort studyFinlandlow back painyouth athletesurheiluvammat030222 orthopedicsliikeoppibusiness.industryHazard ratioriskitekijät030229 sport sciencesGeneral MedicineLow back painSagittal planeBiomechanical PhenomenaReturn to SportTest (assessment)body regionsmedicine.anatomical_structureCoronal planePhysical therapyselkäFemalemedicine.symptombusinessLow Back Painhuman activitiesprospective studyurheilijatPhysical Therapy in Sport
researchProduct

Sex Differences in Feedback: Effects on Rod-and-Frame Performance

1979

It has been demonstrated that feedback is effective in changing rod-and-frame performance for women if given the opportunity to adjust the rod to the vertical repeatedly from the same starting position. It is also shown that the significant difference between males and females in the Rod-and-frame Test is carried by the large difference in the initial tilting position.

MalePsychological Testsgenetic structuresFrame (networking)Significant differenceField Dependence-IndependenceExperimental and Cognitive PsychologySensory SystemsFeedbackForm PerceptionSex FactorsPosition (vector)OrientationStatisticsHumansFemalesense organsMathematicsPerceptual and Motor Skills
researchProduct

Psychometric Assessment of the Japanese Version of the Zurich Claudication Questionnaire (ZCQ): Reliability and Validity.

2016

Purpose The Zurich Claudication Questionnaire (ZCQ) is a self-administered measure to evaluate symptom severity, physical function, and surgery satisfaction in lumbar spinal stenosis (LSS). The purpose of this study is to assess the psychometric properties of the Japanese ZCQ in LSS patients. Methods LSS patients who are scheduled to undergo surgery were recruited from 12 facilities. Responses to several questionnaires, including the Japanese ZCQ; the visual analogue scale (VAS) to evaluate the degree of pain in the buttocks/legs, numbness in the buttocks/legs, and low back pain; the Oswestry Disability Index (ODI); and the SF-36v2, were collected before surgery and again 3 months after sur…

MaleQuestionnairesResearch ValidityPsychometricsSocial Scienceslcsh:MedicinePathology and Laboratory Medicine0302 clinical medicineSpinal StenosisJapanSurveys and QuestionnairesMedicine and Health SciencesPsychology030212 general & internal medicinelcsh:ScienceMusculoskeletal SystemStenosisMultidisciplinaryLumbar VertebraeMiddle AgedResearch AssessmentLow back painOswestry Disability IndexPatient SatisfactionResearch DesignLegsFemalemedicine.symptomAnatomyResearch Articlemedicine.medical_specialtyPsychometricsVisual analogue scaleConcurrent validityLower Back PainPainSurgical and Invasive Medical ProceduresResearch and Analysis Methods03 medical and health sciencesPatient satisfactionPhysical medicine and rehabilitationSigns and SymptomsCronbach's alphaDiagnostic MedicineMental Health and PsychiatrymedicineHumansAgedSurvey Researchbusiness.industryLimbs (Anatomy)lcsh:RBiology and Life SciencesPhysical therapylcsh:QbusinessClaudication030217 neurology & neurosurgeryPLoS ONE
researchProduct

Design considerations of a randomized clinical trial on a cognitive behavioural intervention using communication and information technologies for man…

2013

Background Psychological treatments have been successful in treating chronic low back pain (CLBP). However, the effect sizes are still modest and there is room for improvement. A way to progress is by enhancing treatment adherence and self-management using information and communication technologies (ICTs). Therefore, the objective of this study was to design a trial investigating the short- and long-term efficacy of cognitive behavioural treatment (CBT) for CLBP using or not ICTs. A secondary objective of this trial will be to evaluate the influence of relevant variables on treatment response. Possible barriers in the implementation of CBT with and without ICT will also be investigated. Met…

MaleResearch designmedicine.medical_specialtymedicine.medical_treatmentCognitive behavioural therapyInformation and communication technologiesbehavioral disciplines and activitiesHealth informaticslaw.inventionDisability EvaluationStudy ProtocolPhysical medicine and rehabilitationRheumatologyRandomized controlled triallawparasitic diseasesmedicineHumansPain ManagementLow back painOrthopedics and Sports MedicineRehabilitationCognitive Behavioral Therapybusiness.industryCatastrophizationCommunicationCognitionLow back painResearch DesignSpainCognitive therapyPhysical therapyPatient ComplianceAnxietyFemalemedicine.symptombusinessAttitude to HealthPhysical therapyMedical InformaticsBMC Musculoskeletal Disorders
researchProduct

Individual differences in selective attention predict speech identification at a cocktail party

2016

Listeners with normal hearing show considerable individual differences in speech understanding when competing speakers are present, as in a crowded restaurant. Here, we show that one source of this variance are individual differences in the ability to focus selective attention on a target stimulus in the presence of distractors. In 50 young normal-hearing listeners, the performance in tasks measuring auditory and visual selective attention was associated with sentence identification in the presence of spatially separated competing speakers. Together, the measures of selective attention explained a similar proportion of variance as the binaural sensitivity for the acoustic temporal fine stru…

MaleSelective auditory attentionIndividualitytemporal fine structure sensitivityAudiology0302 clinical medicineAttentionSelective attentionBiology (General)General NeuroscienceQ05 social sciencesRGeneral MedicinehumanitiesMedicineCocktail partyFemaleauditory selective attentionPsychologypsychological phenomena and processesSentenceResearch ArticleHumanAdultmedicine.medical_specialtyQH301-705.5ScienceStimulus (physiology)behavioral disciplines and activitiesworking memory050105 experimental psychologyGeneral Biochemistry Genetics and Molecular BiologyBackground noiseYoung Adult03 medical and health sciencesotorhinolaryngologic diseasesmedicineHumansSpeech0501 psychology and cognitive sciencesindividual differencesGeneral Immunology and MicrobiologyWorking memoryvisual attentionspeech-in-noise identificationNoiseBinaural recording030217 neurology & neurosurgeryNeuroscienceeLife
researchProduct

Facebook profiles reflect actual personality, not self-idealization.

2010

MaleSelf DisclosureAdolescentmedia_common.quotation_subjectFeedback PsychologicalSelf-conceptFriendsTruth DisclosureSocial supportYoung AdultMultidisciplinary approachGermanyPersonalityHumansSocial BehaviorGeneral Psychologymedia_commonInternetMotivationTruth Disclosurebusiness.industryCommunicationSocial SupportSelf ConceptUnited StatesSelf-disclosureIdealizationThe InternetFemalebusinessPsychologySocial psychologyPersonalityPsychological science
researchProduct

Spinal Cord Stimulation and Psychosomatic Conditions

2012

No abstract

MaleSettore MED/27 - Neurochirurgiabusiness.industryElectric Stimulation TherapySpinal cord stimulationDBS Spinal cordSpinal cord stimulation Psychosomatic disordersText miningPatient SatisfactionHumansMedicineFemaleSurgeryNeurology (clinical)Chronic PainFailed Back Surgery SyndromebusinessLow Back PainNeuroscienceNeurosurgery
researchProduct