Search results for "backbone"
showing 10 items of 23 documents
Emergence in 2017-2019 of novel reassortant equine-like G3 rotavirus strains in Palermo, Sicily.
2021
Rotavirus A (RVA) is a major etiologic agent of gastroenteritis in children worldwide. Hospital-based surveillance of viral gastroenteritis in paediatric population in Palermo (Italy) from 2017 onwards revealed a sharp increase in G3P[8] RVAs, accounting for 71% of all the RVAs detected in 2019. This pattern had not been observed before in Italy, with G3 RVA usually being detected at rates lower than 3%. In order to investigate this unique epidemiological pattern, the genetic diversity of G3 RVAs identified during a 16-year long surveillance (2004-2019) was explored by systematic sequencing of the VP7 and VP4 genes and by whole genome sequencing of selected G3 strains, representative of the…
Latency factor in worldwide IP routed networks
2014
Current Border Gateway Protocol (BGP) serves for worldwide internet backbone connections between different Autonomous Systems (AS) on the routing level. Continuously in real-time changing environment core routers calculate routing decisions based on path-vector database entries. AS path-vector database may contain multiple paths for various Internet Protocol (IP) prefix destinations where smallest entity in the path-vector is AS. In real world AS can be internet service operator, university or any other organization willing to participate in internet network via multi-homed uplinks. Unfortunately, internal part of AS is hidden in path-vector database thus excluding factors like latency, pac…
A Geographical Self-Organizing Approach for Vehicular Networks
2012
Cooperative vehicular networks have always been considered as the perfect way to bring more comfort to the passengers and more safety to the human life. Thus, research community and governmental organizations are interested to study and deploy these networks. The vehicular networks principle is connecting vehicles to each other and to existing infrastructure. However, their industrialization faces some challenges: (i) high mobility, (ii) frequently partitioned network, (iii) geographically constrained topology, and (iv) scalability. Therefore, in contrast to traditional networks, vehicular network protocols focus on both achieving adequate QoS level and reducing overhead. Achieving these tw…
Converging and Diverging Synthetic Strategies to Tetradentate (N,N′)-Diaminomethyl,(P,P′)-Ferrocenyl Ligands: Influence of tert-Butyl Groups on Ferro…
2015
Hexasubstituted hybrid tetradentate (N,N′,P,P′)-ferrocenes bearing phosphino and aminomethyl groups, plus hindering tert-butyl moieties, were synthesized by using two different strategies: a “diverging” synthesis involving successive functionalization of preformed di-tert-butylated ferrocene and a “converging” assembly of the species from appropriately substituted cyclopentadienyl rings. While the new cyclopentadienyl salts formed are of interest, their assembly with iron dichloride used as a “converging” way to produce tetradentate ferrocene ligands presented several drawbacks. Conversely, the synthesis of new tert-butylated (aminomethyl)ferrocene derivatives was found convenient to furthe…
NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.
2019
Abstract Background Ubiquitin-like domains (UbLs), in addition to being post-translationally conjugated to the target through the E1-E2-E3 enzymatic cascade, can be translated as a part of the protein they ought to regulate. As integral UbLs coexist with the rest of the protein, their structural properties can differ from canonical ubiquitin, depending on the protein context and how they interact with it. In this work, we investigate T.th-ubl5, a UbL present in a polyubiquitin locus of Tetrahymena thermophila, which is integral to an ADP-ribosyl transferase protein. Only one other co-occurrence of these two domains within the same protein has been reported. Methods NMR, multiple sequence al…
Theoretical study on the effect of backbone conformation on the electronic structure of poly(di-n-butylsilane)
1993
Abstract We present the results of valence effective Hamiltonian (VEH) calculations on the electronic structure of poly(di-n-butylsilane) in its all-trans and 7/3 conformations. The band structure of all-trans conformation is analyzed in detail and the effects of the backbone conformation on the electronic and optical properties are studied. The VEH results for the 2/1 and 7/3 conformations are in excellent quantitative agreement with photoemission and UV-absorption data and show the reliability of the VEH method to deal with organopolysilanes.
A stochastic approach for extracting community-based backbones
2022
Large-scale dense networks are very parvasive in various fields such as communication, social analytics, architecture, bio-metrics, etc. Thus, the need to build a compact version of the networks allowing their analysis is a matter of great importance. One of the main solutions to reduce the size of the network while maintaining its characteristics is backbone extraction techniques. Two types of methods are distinguished in the literature: similar nodes are gathered and merged in coarse-graining techniques to compress the network, while filter-based methods discard edges and nodes according to some statistical properties. In this paper, we propose a filtering-based approach which is based on…
Community-based method for extracting backbones
2022
Networks are an adequate representation for modeling and analyzing a great variety of complex systems. However, understanding networks with millions of nodes and billions of connections can be pretty challenging due to memory and time constraints. Therefore, selecting the relevant nodes and edges of these large-scale networks while preserving their core information is a major issue. In most cases, the so-called backbone extraction methods are based either on coarse-graining or filtering approaches. Coarse-graining techniques reduce the network size by gathering similar nodes into super-nodes, while filter-based methods eliminate nodes or edges according to a statistical property. In this wo…
Influence of the position of two dehydro-amino acids residues in the oligopeptide sequence on the binding ability towards Cu(II) ions
2005
Abstract Studies on the binding ability of bis-dehydro-hexa- and pentapeptides have shown that the hexapeptides bind Cu+2 with similar efficacy as pentapeptides. The increase of distance between two dehydro-amino acid residues in the peptide backbone has no impact on the efficacy in metal ion binding. The type of isomeration [(Z) or (E)] has an influence on the coordination of the metal ion only to the first amide nitrogen.
Structure of bottle brush polymers on surfaces: weak versus strong adsorption.
2011
Large-scale Monte Carlo simulations are presented for a coarse-grained model of cylindrical molecular brushes adsorbed on a flat structureless substrate, varying both the chain length N of the side chains and the backbone chain length N(b). For the case of good solvent conditions, both the cases of weak adsorption (only 10 to 15% of the monomers being bound to the surface) and strong adsorption (~40% of the monomers being bound to the surface, forcing the bottle brush into an almost 2D conformation) are studied. We focus on the scaling of the total linear dimensions of the cylindrical brush with both chain lengths N and N(b), demonstrating a crossover from rod-like behavior (for not very la…