Search results for "basel"

Efficacy and safety of ramucirumab (RAM) for advanced hepatocellular carcinoma (HCC) with elevated alpha-fetoprotein (AFP) following first-line soraf…

2019

Abstract Background REACH (NCT01140347) and REACH-2 (NCT02435433) were two global, randomized, double-blind, placebo (PL)-controlled multicenter, phase 3 studies of RAM vs PL in patients with HCC after prior sorafenib. REACH-2 confirmed overall survival (OS) benefit of RAM for patients with baseline AFP ≥400ng/mL, consistent with results in a prespecified subgroup of patients in REACH with AFP ≥400ng/mL. Methods Post-hoc pooled analyses were performed to examine efficacy and safety in three age subgroups ( Results Both intention-to-treat populations were pooled (542 patients in total). Within each age subgroup, baseline characteristics between treatment arms were similar. Patients of Conclu…

Implementing Ethics in AI: Initial Results of an Industrial Multiple Case Study

2019

Artificial intelligence (AI) is becoming increasingly widespread in system development endeavors. As AI systems affect various stakeholders due to their unique nature, the growing influence of these systems calls for ethical considerations. Academic discussion and practical examples of autonomous system failures have highlighted the need for implementing ethics in software development. However, research on methods and tools for implementing ethics into AI system design and development in practice is still lacking. This paper begins to address this focal problem by providing elements needed for producing a baseline for ethics in AI based software development. We do so by means of an industri…

Measurement invariance of the Behavioural Regulation in Sport Questionnaire when completed by young athletes across five European countries

2013

The purpose of this study was (1) to examine the factorial validity of the Behavioural Regulation Sport in Questionnaire (BRSQ) when completed by young soccer players in the Promoting Adolescent Physical Activity (PAPA) project (9-15 years old) in 5 European countries (France: n = 1248, Greece: n = 1507, Norway: n = 1397, Spain: n = 2245, and England: n = 1372) and (2) test the measurement invariance of its latent factors across these 5 countries.First, we tested the exploratory structural equation model (ESEM) factor analyses, allowing cross-loadings between factors, against the traditional independent clusters confirmatory factor analysis model (ICM-CFA), with all cross-loadings constrain…

Multi-Agent Financial Network (MAFN) Model of US Collateralized Debt Obligations (CDO)

2014

A database driven multi-agent model has been developed with automated access to US bank level FDIC Call Reports that yield data on balance sheet and off balance sheet activity, respectively, in Residential Mortgage Backed Securities (RMBS) and Credit Default Swaps (CDS). The simultaneous accumulation of RMBS assets on US banks’ balance sheets and also large counterparty exposures from CDS positions characterized the $2 trillion Collateralized Debt Obligation (CDO) market. The latter imploded at the end of 2007 with large scale systemic risk consequences. Based on US FDIC bank data, that could have been available to the regulator at the time, the authors investigate how a CDS negative carry …

Bank Lending in Project Finance: The New Regulatory Capital Framework

2012

The paper aims to examine the new regulatory framework of project finance in the economics of banking firms. In particular, the paper investigates the uniqueness of the project finance, the significant importance of the project finance in bank activity, and the role of the new bank capital requirements to promote the innovative financial scheme. In the project finance business loans terms and characteristics are primarily based on the assets and quality of the project to be financed. It means that the usual bank rating models for lending business might not been implemented in the project finance lending. Quantitative estimates of credit risk could not be always possible in project finance l…

Distribution and diversity of fish species exposed to artisanal fishery along the Sudanese Red Sea coast

2019

AbstractThe semi-enclosed Red Sea harbours one of the longest coral-reef ecosystems on the planet. The ≈ 850 km section of the western shore, comprising the coastline of the Red Sea State of the Republic of Sudan, has however been sparsely studied. Sudan’s coral reef fishery provides livelihoods to fishers and business opportunities by means of local and regional trade, however, the knowledge level of the state of the natural resources and the impacts of fisheries are poorly known. Here we report the results from the first three comprehensive fisheries research surveys spanning the entire Sudanese coast in 2012-13, representing a new baseline for the western coast fisheries resources. The s…

Shall we follow? Impact of reputation concern on information security managers’ investment decisions

2020

Information security (infosec) is important for organizations. While budgeting for infosec is a crucial resource allocation decision, infosec managers may choose to follow other fellow experts’ recommendations or baseline practices. The present paper uses reputational herding theory to explain the decision made by infosec managers to use a “let's follow others” strategy in this context. Based on a sample of 106 organizations in Finland, we find that infosec managers’ ability to accurately predict the benefit of infosec investment, as well as their reputations, have significant effects on motivating them to discount their own information. Infosec managers’ discounting of their own informatio…

Capital Regulation with Heterogeneous Banks

2013

We provide a general equilibrium analysis of potential consequences from the introduction of a binding leverage ratio, as proposed in Basel III. If banks differ in their monitoring skills and their ability to successfully complete a risky investment project, a tighter leverage ratio does not only mitigate moral hazard arising from limited liability, but also carries an unintended consequence: Banks are not allowed to absorb the entire supply of debt if they cannot raise new equity, which induces agents with a lower monitoring skill to open a bank. This decreases the average ability of operating banks. We further show that rising heterogeneity in the banking sector increases this negative ef…

Chronic Apical and Nonapical Right Ventricular Pacing in Patients with High-Grade Atrioventricular Block: Results of the Right Pace Study

2018

Objective. The aim of the study was to compare the two approaches to chronic right ventricular pacing currently adopted in clinical practice: right ventricular apical (RVA) and non-RVA pacing. Background. Chronic RVA pacing is associated with an increased risk of atrial fibrillation, morbidity, and even mortality. Non-RVA pacing may yield more physiologic ventricular activation and provide potential long-term benefits and has recently been adopted as standard procedure at many implanting centers. Methods. The Right Pace study was a multicenter, prospective, single-blind, nonrandomized trial involving 437 patients indicated for dual-chamber pacemaker implantation with a high percentage of RV…

2020

Abstract Background and objectives More knowledge is needed of the effectiveness of complex interventions that aim to promote the wellbeing of older people. This study examines the effects of ‘participatory group-based care management’ conducted among community-dwelling older adults living alone in Central and Eastern Finland. The intervention aimed to promote wellbeing and quality of life (QoL) using a needs-based and participatory approach. Methods The study was carried out as a randomized control trial (intervention group n = 185, control group n = 207). In this article, baseline and 6-month follow-up surveys were used. QoL (WHOQOL-Bref instrument), loneliness (Revised UCLA Loneliness Sc…