Search results for "basi"
showing 10 items of 12854 documents
Role of Peripheral Immune Cells-Mediated Inflammation on the Process of Neurodegenerative Diseases
2020
Neurodegenerative diseases are characterized by progressive loss of selectively vulnerable neuronal populations, which contrasts with selectively static loss of neurons due to toxic or metabolic disorders. The mechanisms underlying their progressive nature remain unknown. To date, a timely and well-controlled peripheral inflammatory reaction is verified to be essential for neurodegenerative diseases remission. The influence of peripheral inflammation on the central nervous system is closely related to immune cells activation in peripheral blood. The immune cells activation participated in the uncontrolled and prolonged inflammation that drives the chronic progression of neurodegenerative di…
Interleukin 10 restores lipopolysaccharide-induced alterations in synaptic plasticity probed by repetitive magnetic stimulation
2020
Systemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by LPS-induc…
Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner
2017
Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector functions, which are required for parasite control during leishmaniasis. The aim of this study was to elucidate the impact of the PD-1/PD-L axis in a human primary in vitro infection model of Leishmania major (Lm). Blocking the PD-1/PD-L interaction with nivolumab increased T-cell proliferation and release of the proinflammatory cytokines TNFα and IFNγ during the cocultivation of Lm…
High Performance 3D PET Reconstruction Using Spherical Basis Functions on a Polar Grid
2011
Statistical iterative methods are a widely used method of image reconstruction in emission tomography. Traditionally, the image space is modelled as a combination of cubic voxels as a matter of simplicity. After reconstruction, images are routinely filtered to reduce statistical noise at the cost of spatial resolution degradation. An alternative to produce lower noise during reconstruction is to model the image space with spherical basis functions. These basis functions overlap in space producing a significantly large number of non-zero elements in the system response matrix (SRM) to store, which additionally leads to long reconstruction times. These two problems are partly overcome by expl…
Metabarcoding Analysis of Fungal Diversity in the Phyllosphere and Carposphere of Olive (Olea europaea)
2015
The fungal diversity associated with leaves, flowers and fruits of olive (Olea europaea) was investigated in different phenological stages (May, June, October and December) using an implemented metabarcoding approach. It consisted of the 454 pyrosequencing of the fungal ITS2 region and the subsequent phylogenetic analysis of relevant genera along with validated reference sequences. Most sequences were identified up to the species level or were associated with a restricted number of related taxa enabling supported speculations regarding their biological role. Analyses revealed a rich fungal community with 195 different OTUs. Ascomycota was the dominating phyla representing 93.6% of the total…
A siliciclastic shallow-marine turbidite on the carbonate shelf of the Ordovician Baltoscandian palaeobasin
2019
A metre-scale thick siltstone–sandstone lobe is described within the Dapingian outer ramp argillaceous limestone facies of the Baltoscandian palaeobasin. This bed is referred to as the Volkhov Oil Collector in previous studies due to its hydrocarbon accumulation potential. It formed on the palaeoslope of the regional Jelgava Depression, which represents an elongated axial region of the deepest part of the Ordovician Baltoscandian sedimentary basin. Sedimentological and petrological analysis of this siliciclastic bed in core sections shows that it was deposited as a result of a single event of turbidite flow. The internal structure of the turbidite bed follows the classical Bouma divisions o…
Electrocardiographic Imaging Using a Spatio-Temporal Basis of Body Surface Potentials—Application to Atrial Ectopic Activity
2018
Electrocardiographic imaging (ECGI) strongly relies on a priori assumptions and additional information to overcome ill-posedness. The major challenge of obtaining good reconstructions consists in finding ways to add information that effectively restricts the solution space without violating properties of the sought solution. In this work, we attempt to address this problem by constructing a spatio-temporal basis of body surface potentials (BSP) from simulations of many focal excitations. Measured BSPs are projected onto this basis and reconstructions are expressed as linear combinations of corresponding transmembrane voltage (TMV) basis vectors. The novel method was applied to simulations o…
Spectrofluorimetric study of dissolved organic matter in River Salaca (Latvia) basin waters
2012
Dissolved organic matter (DOM) in surface waters influences mineral weathering, nutrient cycling, aggregation of particulate matter and photochemical reactions in waters and aquatic communities. In this study, the effectiveness of UV and fluorescence measurements in distinguishing the origin of DOM and processes within the river basin were analyzed using the River Salaca basin as an example. The basin of River Salaca is characterized by low anthropogenic pressure, however, the water color during the last few decades has increased (an effect known as brownification). As tools to study the composition of dissolved organic substances in waters of the River Salaca and its tributaries the use of…
Physical activity, nutrition, and bone health
2018
This review aims to describe the roles that physical activity and nutrition have in bone metabolism and to examine their effects on bone in a situation of altered metabolism as a consequence of inadequate nutrition and/or excessive physical activity. Referring to the recent studies and the main guidelines in the literature on athlete nutrition, the paper also focuses on essential nutrients for bone health during performance. Finally, it discusses the negative effect of some nutrients on bone mineral density.
Development of basic psychological need satisfaction in physical education
2019
Research shows that sports-active students experience more basic need satisfaction (autonomy, competence, relatedness) in physical education (PE) than their non-sports-active peers, and thus, reap most of the benefits of PE. This study aimed to investigate the role of a two-year PE programme, referred to as Interest-based PE, in contributing to students’ basic need satisfaction in PE, and in particular, to assess potential basic needs-benefits among students who were not involved in leisure-time sport. Among 693 students, 348 were offered a choice of two different PE approaches (“explorative” vs. “sports” approach) for the next two years, while the remaining students continued to receive tr…