Search results for "basic research"

Der Nachweis zellulärer Reaktionen im kondylären Kiefergelenkknorpel mittels NMR-Mikroskopie Grundlagenuntersuchungen für eine hochaufgelöste Kernspi…

1992

Das regionale Auflosungsvermogen moderner bildgebender Verfahren reicht heute noch nicht aus, um Veranderungen des mandibularen Gelenkknorpels, zum Beispiel bei funktionskieferorthopadischer Behandlung, klinisch zu objektivieren. In tierexperimentellen Untersuchungen am Kiefergelenk des Hausschweins wurden auf der Grundlage von H-NMR-relaxometrischen Messungen an kondylaren Knorpelproben NMR-mikroskopische Untersuchungen am intakten Kiefergelenkpraparat durchgefuhrt. Dabei gelang es, den mandibularen Gelenkknorpel bis hin zur zellularen Ebene darzustellen und Regenerationsprozesse als Spafolge eines operativen Eingriffs am Kiefergelenk nachzuweisen. Die Ergebnisse wurden hinichtlich ihrer B…

Why is genetic modification of interest or why can it be useful?

2020

Abstract The genetic modification is a widely debated topic. Pros and cons are substantiated with scientific results or by biased interpretation of experimental results and potential hazards. Genetic modification is a naturally occurring phenomenon. Basic research type of application of genetic modification is teaching us important lessons about the implication of genes in every aspects of life. The applied research–related genetic modifications are offering unprecedented solutions to make plants, animals, and microorganisms bring more benefits, while their impact on environment and human health once they are released into field or get introduced into the food chain needs case-to-case asses…

Yrjö Blomstedtin ja Victor Sucksdorffin Kainuu

2016

A View from the Inside: The Dawning Of De-Westernization of CEE Media and Communication Research?

2015

The Editorial outlines some characteristics of the development of the Central and Eastern European (CEE) media and communication scholarship during the past 25 years. In the majority of CEE countries, the media and communication research was re-established after the collapse of communism. Since then, a critical mass of active scholars has appeared who form an integral part of the larger European academia. A gradual integration of East and West perspectives in media and communication research is taking place along with moving away from the barely West-centred approach, and utilizing the research done by CEE scholars. Certain 'de-westernization' and internationalization of the research in ter…

Fluorescence Microscopy Studies of Structure Formation in Surfactant Monolayers

1993

Monolayers of water-insoluble surfactants (Langmuir monolayers) are important model system in basic research for studying the self-organization of organic molecules into two-dimensional layers [1, 2]. These floating films are also the basis for the build-up of complex multilayered structures on solid substrates, so-called Langmuir—Blodgett films (LB-films), which are of considerable interest in fundamental science and promise some future practical applications [3].

Infant Event-Related Potentials to Speech are Associated with Prelinguistic Development

2020

Highlights • Speech processing and prelinguistic skills studied in a large longitudinal sample. • Auditory ERPs predicted prelinguistic development in infancy in LCS models. • P1 amplitude at 6 months predicted prelinguistic development between 6 and 12 months. • MMR to a frequency change was associated with prelinguistic skills at 6 months. • Infants’ neural speech processing can help to predict early language development.

Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA

2022

Contains fulltext : 248375.pdf (Publisher’s version ) (Closed access) BACKGROUND: Gitelman syndrome is the most frequent hereditary salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. Gitelman syndrome is caused by biallelic pathogenic variants in SLC12A3, encoding the Na(+)-Cl(-) cotransporter (NCC) expressed in the distal convoluted tubule. Pathogenic variants of CLCNKB, HNF1B, FXYD2, or KCNJ10 may result in the same renal phenotype of Gitelman syndrome, as they can lead to reduced NCC activity. For approximately 10 percent of patients with a Gitelman syndrome phenotype, the genotype is unknown. METHODS: We identified mitochondrial DNA (mtDNA) variants in th…

Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis

2009

Macrophages mediate kidney disease and are prominent in a mouse model (MRL- Fas lpr ) of lupus nephritis. Colony stimulating factor-1 (CSF-1) is the primary growth factor for macrophages, and CSF-1 deficiency protects MRL- Fas lpr mice from kidney disease and systemic illness. Whether this renoprotection derives from a reduction of macrophages and whether systemic CSF-1, as opposed to intrarenal CSF-1, promotes macrophage-dependent lupus nephritis remain unclear. Here, we found that increasing systemic CSF-1 hastened the onset of lupus nephritis in MRL- Fas lpr mice. Using mutant MRL- Fas lpr strains that express high, moderate, or no systemic CSF-1, we detected a much higher tempo of kidne…

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

2011

Objectives: Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD. Methods: Confocal endomicroscopy was performed in IBD and control patients using intravenous fluorescein to determine the relationship between cell shedding and local barrier dysfunction. A grading system based on appearances at confocal endomicroscopy in humans was devise…

In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy.

2007

AIM: To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents. METHODS: A novel rigid confocal probe (diameter 7 mm) was designed with optical features similar to the flexible endomicroscopy system for use in humans using a 488 nm single line laser for fluorophore excitation. Light emission was detected at 505 to 750 nm. The field of view was 475 μm × 475 μm. Optical slice thickness was 7 μm with a lateral resolution of 0.7 μm. Subsurface serial images at different depths (surface to 250 μm) were generated in real time at 1024 × 1024 pixels (0.8 frames/s) by placing the probe onto the tissue in gentle, stable co…