Search results for "bbb"
showing 8 items of 28 documents
The close link between brain vascular pathological conditions and neurodegenerative diseases: Focus on some examples and potential treatments
2022
A close relationship is emerging among the age-related neurodegenerative decline, and the age-related typical alterations, dysfunctions, and related diseases of the cerobro-and/or cardiovascular system, which contributes in a significative manner to the triggering and progressing of neurodegenerative diseases (NeuroDegD). Specifically, macroinfarcts, microinfarcts, micro-hemorrhages (and particularly their number), atherosclerosis, arteriolosclerosis and cerebral amyloid angiopathy have been documented to be significantly associated with the onset of the cognitive impairment. In addition, vascular alterations and dysfunctions resulting in a reduced cerebral blood flow, and anomalies in the …
Hans Fallada E adesso, pover'uomo? ISBN 88-389-2338-8 Sellerio: Palermo
2008
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EXTRACELLULAR FACTORS INVOLVED IN THE INDUCTION OF BLOOD BRAIN BARRIER (BBB)
2005
In vitro models of BBB: a tool for the analysis of cell to cell communication in the brain
2008
Many researchers have been trying to set in vitro models of the blood-brain barrier (BBB) aimed at analyzing, in simplified terms, the molecular mechanisms responsible for formation, maintenance and functioning of the BBB, as well as the capability of specific drugs and pro-drugs to cross BBB. We did it, starting with a simpler system of co-culture that allowed us to analyze the effects of neurons on differentiation of brain capillary endothelial cells (RBE4.B cells) in culture, and setting then a more complex model, that includes three cell types (endothelial cells, neurons and astrocytes). The reciprocal geometrical organization of brain cells in this model system is similar to the one ob…