Search results for "benzimidazole"

showing 10 items of 161 documents

New Frontiers in the Treatment of Homozygous Familial Hypercholesterolemia.

2021

: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder. The most common cause is a mutation in both alleles of the gene encoding for the low-density lipoprotein (LDL) receptor, although other causative mutations have been identified. Complications of atherosclerotic cardiovascular disease are common in these patients; therefore, reducing the elevated LDL-cholesterol burden is critical in their management. Conventionally, this is achieved by patients initiating lipid-lowering therapy, but this can present challenges in clinical practice. Fortunately, novel therapeutic strategies have enabled promising innovations in HoFH treatment. This review highlights recent and ongo…

Settore MED/09 - Medicina InternaGenetic enhancementHomozygous familial hypercholesterolemiaFamilial hypercholesterolemiaInclisiranBioinformaticsmedicine.disease_causeBenzimidazolePCSK9Hyperlipoproteinemia Type IIchemistry.chemical_compoundGene therapyAnticholesteremic AgentmedicineAngiopoietin-like 3HumansLow-density lipoprotein cholesterolAlleleAngiopoietin-like 3; Gene therapy; Gene-editing; Homozygous familial hypercholesterolemia; Inclisiran; Lomitapide; Low-density lipoprotein cholesterol; PCSK9MutationGene-editingAtherosclerotic cardiovascular diseasebusiness.industryPCSK9Anticholesteremic AgentsHomozygoteGenetic disorderGeneral MedicineCholesterol LDLmedicine.diseaseLomitapideLomitapidechemistrylipids (amino acids peptides and proteins)BenzimidazolesCardiology and Cardiovascular MedicinebusinessHumanHeart failure clinics
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CCDC 2106007: Experimental Crystal Structure Determination

2021

Related Article: Essi Taipale, Marcel Siepmann, Khai-Nghi Truong, Kari Rissanen|2021|Chem.-Eur.J.|27|17412|doi:10.1002/chem.202103152

Space GroupCrystallography(acetonitrile)-bis(1-ethyl-1H-benzimidazole)-silver hexafluorophosphateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1449799: Experimental Crystal Structure Determination

2016

Related Article: Miriam Más-Montoya, Laura Usea, Arturo Espinosa Ferao, María F. Montenegro, Carmen Ramírez de Arellano, Alberto Tárraga, José N. Rodríguez-López, and David Curiel|2016|J.Org.Chem.|81|3296|doi:10.1021/acs.joc.6b00265

Space GroupCrystallography13-octyl-77-diphenyl-7H13H-8lambda57lambda5-indolo[1'7':345][132]diazaborinino[16-a][31]benzimidazoleCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 218918: Experimental Crystal Structure Determination

2004

Related Article: E.Mas-Marza, M.Poyatos, M.Sanau, E.Peris|2004|Inorg.Chem.|43|2213|doi:10.1021/ic035317p

Space GroupCrystallographyChloro-(eta^4^-cyclo-octa-15-diene)-(2-(13-dimethyl-13-dihydro-2H-benzimidazol-2-yl)-1-methylbenzimidazole-N)-rhodiumCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 722408: Experimental Crystal Structure Determination

2010

Related Article: M.Leboschka, M.Sieger, B.Sarkar, J.Heck, M.Niemeyer, D.Bubrin, F.Lissner, T.Schleid, S.Zalis, Cheng-Yong Su, W.Kaim|2009|Z.Anorg.Allg.Chem.|635|2177|doi:10.1002/zaac.200900265

Space GroupCrystallographyChloro-bis(2-((methylselanyl)methyl)-1H-benzimidazole)-copper(ii) chloride methanol solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1519074: Experimental Crystal Structure Determination

2017

Related Article: Marta Martínez-Alonso, Jesús Cerdá, Cristina Momblona, Antonio Pertegás, José M. Junquera-Hernández, Aránzazu Heras, Ana M. Rodríguez, Gustavo Espino, Henk Bolink, and Enrique Ortí|2017|Inorg.Chem.|56|10298|doi:10.1021/acs.inorgchem.7b01167

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-methyl-2-(13-thiazol-4-yl)-1H-benzimidazole)-bis(2-(pyridin-2-yl)phenyl)-iridium(iii) hexafluorophosphateExperimental 3D Coordinates
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CCDC 160956: Experimental Crystal Structure Determination

2002

Related Article: E.A.Goreshnik, D.Schollmeyer, M.G.Myskiv|2002|Z.Anorg.Allg.Chem.|628|2118|doi:10.1002/1521-3749(200209)628:9/10<2118::AID-ZAAC2118>3.0.CO;2-L

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(eta^2^-2-(Allylthio)benzimidazole-N)-chloro-copper(i)Experimental 3D Coordinates
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CCDC 2106011: Experimental Crystal Structure Determination

2021

Related Article: Essi Taipale, Marcel Siepmann, Khai-Nghi Truong, Kari Rissanen|2021|Chem.-Eur.J.|27|17412|doi:10.1002/chem.202103152

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters156-trimethyl-1H-benzimidazol-3-ium 156-trimethyl-1H-benzimidazole iodideExperimental 3D Coordinates
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CCDC 2106012: Experimental Crystal Structure Determination

2021

Related Article: Essi Taipale, Marcel Siepmann, Khai-Nghi Truong, Kari Rissanen|2021|Chem.-Eur.J.|27|17412|doi:10.1002/chem.202103152

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-ethyl-56-dimethyl-1H-benzimidazoleExperimental 3D Coordinates
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CCDC 722407: Experimental Crystal Structure Determination

2010

Related Article: M.Leboschka, M.Sieger, B.Sarkar, J.Heck, M.Niemeyer, D.Bubrin, F.Lissner, T.Schleid, S.Zalis, Cheng-Yong Su, W.Kaim|2009|Z.Anorg.Allg.Chem.|635|2177|doi:10.1002/zaac.200900265

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-((Methylselanyl)methyl)-1H-benzimidazoleExperimental 3D Coordinates
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