Search results for "benzopyran"

showing 10 items of 60 documents

Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) towar…

2013

Abstract Introduction Resistance of cancer cells to chemotherapy has become a worldwide concern. Naturally occuring isoflavonoids possess a variety of biological activities including anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three naturally occuring isoflavonoids, neobavaisoflavone ( 1 ), sigmoidin H ( 2 ) and a pterocarpan that is a special type of isoflavonoid, isoneorautenol ( 3 ) against a panel of nine cancer cell lines, including various sensitive and drug-resistant phenotypes. Methods The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was used to detect t…

Pharmaceutical ScienceApoptosisIsoflavonoidDrug DiscoveryHumansCytotoxic T cellBenzopyransCytotoxicityCaspaseBenzofuransErythrinaMembrane Potential MitochondrialPharmacologybiologyCell CyclePterocarpanHCT116 CellsAntineoplastic Agents PhytogenicIsoflavonesMolecular biologyComplementary and alternative medicineBiochemistryDrug Resistance NeoplasmCell cultureApoptosisCaspasesCancer cellbiology.proteinMolecular MedicineDrug Screening Assays AntitumorReactive Oxygen SpeciesPhytomedicine
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Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compou…

1997

When 56 flavonoids, 32 coumarins, five naphthoquinones, 12 anthraquinones and five structurally-related compounds were tested for their antimutagenic potencies with respect to mutagenicities induced by 2-nitrofluorene (2-NF), 3-nitrofluoranthene (3-NFA) and 1-nitropyrene (1-NP) in Salmonella typhimurium TA98 distinct structure-activity relationships were detected. First, the tetracyclic nitroarenes 3-NFA and 1-NP were in general more effectively antagonized by potent antimutagenic flavonoids and coumarins than the tricyclic 2-NF, while there were only minor differences with quinones. Secondly, antimutagenicity of natural compounds of plant origin correlated with the aglyconic nature 10 of a…

Salmonella typhimuriumStereochemistryToxicologyAnthroneFlavoneschemistry.chemical_compoundFlavonolsPhenolsAnthraquinonesAnimalsOrganic chemistryBenzopyransPhenolsFlavonoidschemistry.chemical_classificationFluorenesPyrenesMutagenicity TestsPlant ExtractsChemistryAntimutagenic AgentsGeneral MedicineNaphthoquinoneAntimutagenFlavanoneMutagensFood ScienceFood and Chemical Toxicology
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Flow cytometric kinetic assay of the activity of Na+/H+ antiporter in mammalian cells.

2004

Background The Na+/H+ exchanger (NHE) of mammalian cells is an integral membrane protein that extrudes H+ ion in exchange for extracellular Na+ and plays a crucial role in the regulation of intracellular pH (pHi). Thus, when pHi is lowered, NHE extrudes protons at a rate depending of pHi that can be expressed as pH units/s. Methods To abolish the activity of other cellular pH-restoring systems, cells were incubated in bicarbonate-free Dulbecco's modified Eagle's medium buffered with HEPES. Flow cytometry was used to determine pHi with 2′,7′-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester or 5-(and-6)-carboxy SNARF-1 acetoxymethyl ester acetate, and the appropriate fluo…

Sodium-Hydrogen ExchangersTime FactorsNigericinIntracellular pHBiophysicsIonophoreNaphtholsBiochemistryModels BiologicalPathology and Forensic MedicineFlow cytometryCell Linechemistry.chemical_compoundJurkat CellsMiceEndocrinologyChondrocytesIschemiamedicineExtracellularAnimalsHumansBenzopyransMuscle SkeletalCells CulturedFluorescent DyesHEPESmedicine.diagnostic_testDose-Response Relationship DrugRhodaminesCell BiologyHematologyHydrogen-Ion ConcentrationFlow CytometryFluoresceinsAmilorideKineticsBiochemistrychemistryCell cultureCalibrationNIH 3T3 Cellsmedicine.drugCytometry. Part A : the journal of the International Society for Analytical Cytology
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CCDC 1840041: Experimental Crystal Structure Determination

2018

Related Article: Yasushi Imada, Johannes L. Röckl, Anton Wiebe, Tile Gieshoff, Dieter Schollmeyer, Kazuhiro Chiba, Robert Franke, Siegfried R. Waldvogel|2018|Angew.Chem.,Int.Ed.|57|12136|doi:10.1002/anie.201804997

Space GroupCrystallography7-hydroxy-3-[(4-hydroxy-35-dimethylphenyl)methyl]-4-methyl-2H-1-benzopyran-2-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 914330: Experimental Crystal Structure Determination

2013

Related Article: Y.Rousselin, A.Bruel, A.Clavel|2012|Acta Crystallogr.,Sect.E:Struct.Rep.Online|68|o3352|doi:10.1107/S1600536812045813

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(SSSS)-bis[2-(6-Fluoro-34-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]ammonium chloride hemihydrateExperimental 3D Coordinates
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CCDC 1912053: Experimental Crystal Structure Determination

2020

Related Article: Luka Ðorđević, Cataldo Valentini, Nicola Demitri, Cécile Mézière, Magali Allain, Marc Sallé, Andrea Folli, Damien Murphy, Samuel Mañas-Valero, Eugenio Coronado, Davide Bonifazi|2020|Angew.Chem.,Int.Ed.|59|4106|doi:10.1002/anie.201914025

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters210-di-t-butyl[1]benzopyrano[4'3'2':89]phenanthro[345-mnab]xanthene 210-di-t-butyl[1]benzopyrano[4'3'2':89]phenanthro[345-mnab]xanthene radical hexafluorophosphate tetrahydrofuran solvateExperimental 3D Coordinates
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CCDC 1987379: Experimental Crystal Structure Determination

2020

Related Article: Yoseph Atilaw, Lois Muiva-Mutisya, Jonathan Bogaerts, Sandra Duffy, Arto Valkonen, Matthias Heydenreich, Vicky M. Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2020|J.Nat.Prod.|83|2390|doi:10.1021/acs.jnatprod.0c00245

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters5'7'-dihydroxy-57-dimethoxy-88'-bis(3-methylbut-2-en-1-yl)-22'-diphenyl-2'33'4-tetrahydro-2H4'H-[46'-bi-1-benzopyran]-4'-oneExperimental 3D Coordinates
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CCDC 1937081: Experimental Crystal Structure Determination

2019

Related Article: Stephen S. Nyandoro, Gasper Maeda, Joan J.E. Munissi, Amra Gruhonjic, Paul A. Fitzpatrick, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Fangfang Pan, Rakesh Puttreddy, Vicky M. Avery, Máté Erdélyi|2019|Molecules|24|2746|doi:10.3390/molecules24152746

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters5-hydroxy-6-[(2-hydroxyphenyl)methyl]-7-methoxy-2-phenyl-23-dihydro-4H-1-benzopyran-4-oneExperimental 3D Coordinates
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CCDC 1899383: Experimental Crystal Structure Determination

2019

Related Article: Fernando Rabasa-Alcañiz, Daniel Hammerl, Anabel Sánchez-Merino, Tomás Tejero, Pedro Merino, Santos Fustero, Carlos del Pozo|2019|Org.Chem.Front.|6|2916|doi:10.1039/C9QO00525K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters7-(trifluoromethyl)-6a77a1014b15a-hexahydro-6H8H9aH-[1]benzopyrano[3'4':45]pyrrolo[12-d]indeno[21-b][14]oxazin-8-oneExperimental 3D Coordinates
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CCDC 1430059: Experimental Crystal Structure Determination

2016

Related Article: Maria Michela Dell'Anna, Valentina Censi, Benedetta Carrozzini, Rocco Caliandro, Nunzio Denora, Massimo Franco, Daniele Veclani, Andrea Melchior, Marilena Tolazzi, Piero Mastrorilli|2016|J.Inorg.Biochem.|163|346|doi:10.1016/j.jinorgbio.2016.08.006

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscis-(4-(357-trihydroxy-4-oxo-4H-1-benzopyran-2-yl)benzene-12-bisolato)-bis(triphenylphosphine)-platinum(ii)Experimental 3D Coordinates
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