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showing 10 items of 409 documents
Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development
2012
Advanced therapy medicinal products (ATMPs), including cell therapy products, form a new class of medicines in the European Union. Since the ATMPs are at the forefront of scientific innovation in medicine, specific regulatory framework has been developed for these medicines and implemented from 2009. The Committee for Advanced Therapies (CAT) has been established at the European Medicines Agency (EMA) for centralized classification, certification and evaluation procedures, and other ATMP-related tasks. Guidance documents, initiatives, and interaction platforms are available to make the new framework more accessible for small- and medium-sized enterprises, academia, hospitals, and foundation…
El análisis marxista de las necesidades sociales
2018
The disappearance of the so-called «real socialism» has concealed the validity of the Marxist analysis of social reality. One of the sets of hypotheses that has best maintained its heuristic capacity is the Marxist theory of needs. The Marxist hypotheses have been developed in debate with other conventional conceptions. Currently, feminism and the ecological analysis of needs are renewing the views of Heller and Habermas.
Le char du tumulus du Trembloi, commune de Magny-Lambert (Côte-d’Or)
2013
L’étude des collections protohistoriques du Musée archéologique de Dijon nous a mené à enquêter sur un fragment de moyeu de char hallstattien conservé dans la collection Brulard et indiqué comme provenant du tumulus du Trembloi à Magny-Lambert (Côte-d’Or). Si, depuis les travaux de R. Joffroy, le doute concernant la provenance de cet objet semblait permis, la mise à notre disposition de l’inventaire du musée ainsi que des manuscrits inédits du docteur Brulard et les détails qu’ils révèlent permettent de contredire cette thèse. Study of the protohistoric collections in the Archaeological Museum of Dijon led to us to investigate a fragment of an iron hub from an early Iron Age wagon in the Br…
‘Popoli fantastici nei Bestiari’, in Le lingue e le letterature germaniche fra il XII e il XVI secolo. Atti del XXIX Convegno dell’Associazione Itali…
2004
The essay explores the several 'phantastic' beeings included in medieval Bestiaries, looking at their sources, changes, distribution and iconography.
Age-dependent changes of nuclear envelope protein phosphokinase and protein phosphatase activities. Significance for altered nucleo-cytoplasmic mRNA …
1984
Nuclear envelopes are associated with a protein phosphokinase and a phosphoprotein phosphatase, whose activities are modulated by poly(A) in an opposite manner. The activities of these enzymes were determined in nuclear ghosts from liver and oviduct of quails of different age and of different hormone status. Under optimal conditions, kinase activity was found to increase in immature animals 8-fold in response to diethylstilbestrol; co-administration of progesterone had no marked effect on enzyme activity. After the initial burst, the activity of the enzyme increased only slightly during ageing. Two proteins present in nuclear ghosts of Mr 64 000 and of Mr 106 000 are phosphorylated during t…
Ocular counterrolling. Some practical considerations of a new evaluation method for diagnostic purposes.
1986
Ocular counterrolling (OCR) data taken from the literature (12 publications) were used to test the best fit (least-square fit) of these measurements with respect to three mathematical models: a sine relation between OCR and the lateral tilt stimulus, a complex cosine-square relation, and a logarithmic relation between OCR gain and tilt. The latter proved to be the best fitting function. On the basis of this model, we attempted to define a physiological transfer function between OCR gain and tilt, which could serve as a reference of normal population, assuming healthy subjects for the investigations applied. Comparison of this physiological range with pathological data demonstrated marked di…
The effectiveness of the Feldenkrais method: a systematic review of the evidence
2014
The Feldenkrais Method (FM) has broad application in populations interested in improving awareness, health, and ease of function.This review aimed to update the evidence for the benefits of FM, and for which populations. A best practice systematic review protocol was devised. Included studies were appraised using the Cochrane risk of bias approach and trial findings analysed individually and collectively where possible. Twenty RCTs were included (an additional 14 to an earlier systematic review). The population, outcome, and findings were highly heterogeneous. However, meta-analyses were able to be performed with 7 studies,finding in favour of the FM for improving balance in ageing populati…
Alterations of DNA-dependent DNA polymerase activities in the immature quail oviduct in response to estrogen stimulation.
1975
Administration of diethylstilbestrol, an estrogen analogue, to immature female quails causes an increase of extractable DNA-dependent DNA polymerase activities from the oviduct. At least two forms of polymerases have been determined, a high molecular weight polymerase (210,000 daltons) and a low molecular weight polymerase (34,000 daltons) calculated from column chromatography Sephadex G-200. During the primary hormone stimulation the amount of extractable enzyme reaches a maximum on the fifth day after daily injections of the hormone. In the period of withdrawal the activities decrease and reach values similar to those determined in the unstimulated oviducts. During secondary stimulation t…
Clinical trials in children.
2006
Abstract Randomized controlled clinical trials are felt by the medical community to provide the best evidence. Participation in trials involves the possibility of obtaining benefits but also of suffering some risks. Those risks are often considered unacceptable for children but if clinical trials are not conducted in children, clinicians are forced to extrapolate study data from adults. In 1968 H. Shirkey termed children "therapeutic orphans" because of the lack of adequately tested and labeled drugs available in appropriate formulations. Research involving children entails specific difficulties as the need to study children of different ages, the small number of children affected by certai…
Personalised Medicine in National Cancer Plans: How Can Innovation Be Translated Into Policy?
2014
ABSTRACT Stratified, precision or personalised medicine (PM) is emerging as one of the most important areas of clinical innovation in cancer care. Yet, implementing policies to translate these innovations to practice entails deep changes, including in how patient information is treated, how funding is allocated, how diagnostic tests are validated and carried out, how care is organised, how clinical trials are conducted and how new drugs are approved. National Cancer Control Programmes (NCCPs), for their part, have emerged as the primary instrument to coordinate the range of cancer control policies within individual countries, and virtually all European countries have adopted one. This means…