Search results for "beta"

HYALURONIC ACID/-CYCLODEXTRINS HYDROGEL FOR CORNEAL RELEASE OF EPITHELIAL CELLS AND DEXAMETHASONE

2015

Genetics of familial hypobetalipoproteinemia

2007

Primary hypobetalipoproteinemias include three monogenic disorders: the relatively frequent codominant familial hypobetalipoproteinemia (FHBL), the rare recessive conditions abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD). Approximately 50% of FHBL patients are carriers of mutations in the APOB gene, mostly causing the formation of truncated forms of ApoB. In some kindred, FHBL is linked to a locus on chromosome 3 (3p21), but the candidate gene is still unknown. Recently, a FHBL-like phenotype was observed in carriers of mutations of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene causing loss-of-function of the encoded protein, a proprotein convertase tha…

Melleņu ģints ogu spiedpalieku ekstraktu ietekme uz dziļās glikēšanas gala produktu veidošanos un beta amiloīdproteīna agregāciju in vitro

2020

Bakalaura darbā tika pētīta Vaccinium ģints piecu ogu izspaidu ekstraktu spēja inhibēt advancēto glikēšanas gala produktu (AGE) un Abeta proteīna 1-42 agregātu veidošanos in vitro. Ekstraktu efektus pētījām uz AGE veidošanos seruma albumīna un metilglioksāla reakcijā un uz Abeta 1-42 spontāno agregāciju paaugstinātā temperatūrā un reakcijā ar metilglioksālu. Iegūtie rezultāti parāda, ka pētītie ogu ekstrakti inhibē AGE un Abeta 1-42 agregātu veidošanos. Melleņu ekstrakts efektīvāk par citiem ekstraktiem inhibēja AGE veidošanos, salīdzinot ar kontroli, bet Abeta 1-42 agregāciju visefektīvāk inhibēja lielogu dzērveņu un purva dzērveņu ogu izspaidu ekstrakti.

Retirada del tratamiento betabloqueante en pacientes con insuficiencia cardíaca con función sistólica preservada e incompetencia cronotrópica. Efecto…

2022

La insuficiencia cardiaca con fracción de eyección preservada presenta una fisiopatología compleja y multifactorial. Entre los potenciales mecanismos, la incompetencia cronotrópica podría contribuir a la limitación de la capacidad funcional. Cabe reseñar que un gran porcentaje de pacientes con insuficiencia cardiaca con fracción de eyección preservada reciben tratamiento con betabloqueantes a pesar de la falta de evidencia en este perfil de pacientes. Con estas premisas, la hipótesis fue que la retirada del tratamiento betabloqueante en pacientes con insuficiencia cardiaca con fracción de eyección preservada, con criterios de estabilidad clínica, en tratamiento crónico y estable con betablo…

Theoretical study of neutrino scattering off the stable even Mo isotopes at low and intermediate energies

2011

A systematic study of the cross sections of neutral-current neutrino scattering off the stable even Mo isotopes (mass number A = 92, 94, 96, 98, 100), at low and intermediate neutrino energies (E(nu) <= 130 MeV), is presented and discussed. The required wave functions for the initial (ground state) and all accessible final nuclear states are constructed in the context of the quasi-particle random-phase approximation (QRPA) and tested against data on the low-lying energy spectra of the isotopes in question. The individual contributions coming from the polar-vector and axial-vector components of the hadronic current for the coherent and incoherent channels of each isotope are investigated. Th…

Chemical and physical characterization of thermal aggregation of model proteins modulated by zinc(II) and copper(II) ions

2016

BACKGROUND: Metal ions are implicated in protein aggregation processes of several neurodegenerative pathologies, where the protein deposition occurs, and in the biotechnology field like the food technology where many processes in food manufacturing are based on thermal treatments. OBJECTIVE: The influence of Cu2+ or Zn2+ ions on the thermal aggregation process of Bovine beta-lactoglobulin (BLG) and Bovine Serum Albumin (BSA), two protein models, was studied with the aim of delineating the role of these ions in the protein aggregation kinetics and to clarify the related molecular mechanisms. METHODS: The protein structure changes were monitored by Raman spectroscopy, whereas the aggregate gr…

Metal ions modulate thermal aggregation of betalactoglobulin: a join chemical and physical characterization

2014

Abstract Molecular basis of the role played by Cu 2 + and Zn 2 + ions during the thermal aggregation processes of beta-lactoglobulin (BLG) was studied by using a joint application of different techniques. In particular, Raman spectroscopy was very useful in identifying the different effects caused by the two metals at molecular level (i.e. changes in His protonation state, disulfides bridge conformation, and micro-environment of aromatic residues), evidencing the primary importance of the protein charge distribution during the aggregation process. Both metal ions are able to act on this factor and favor the protein aggregation, but Zn 2 + is able to alter the natural conformational state of…

Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties

2020

This work was supported by the European Social Fund under the No. 09.3.3- LMT-K-712 “Development of Competences of Scientists, other Researchers and Students through Practical Research Activities” measure. AK would like to express sincere gratitude for Fellowship administrated by The Japan Society for the Promotion of Science (JSPS). Fellow’s ID No.: L12546. Authors are grateful to R. Vargalis (Vilnius University) for taking SEM images. © 2020. This work is licensed under a CC BY-NC-ND license.

Fe-doped Beta zeolite from organotemplate-free synthesis for NH3-SCR of NOx

2016

Two types of Beta zeolites, one from organotemplate-free synthesis with a Si/Al ratio of 9 and the other from a commercial one with a Si/Al ratio of 19, were employed here to dope Fe for NH3-SCR of NOx. Fe-Beta (Si/Al = 9) exhibits much higher activity than Fe-Beta (Si/Al = 19), especially at low-temperature regions (<250 °C). In addition, it also exhibits better hydrothermal stability as compared with Fe-Beta (Si/Al = 19), which demonstrates that it is a promising SCR catalyst with good activity as well as hydrothermal stability. The correlation between the quantitative calculation of the content of isolated Fe3+ in Beta zeolites and the NO conversion rate at 150 °C shows a linear relation…

Improvement of catalytic activity over Cu--Fe modified Al-rich Beta catalyst for the selective catalytic reduction of NOx with NH3

2016

Copper and iron bimetal modified Al-rich Beta zeolites from template-free synthesis were prepared for selective catalytic reduction (SCR) of NOx with NH3 in exhaust gas streams. Comparing to the Cu-based and Fe-based mono-component Beta catalysts, Cu(3.0)-Fe(1.3)-Beta bi-component catalyst shows better low-temperature activity and wider reaction-temperature window. Over 80% of NO conversion can be achieved at the temperature region of 125–500 °C. Due to the synergistic effect of copper and iron evidenced by XRD, UV–Vis–NIR, EPR and XPS measurements, the dispersion state of active components as well as the ratio of Cu2+/Cu+ and Fe3+/Fe2+ were improved over Cu(3.0)-Fe(1.3)-Beta. Isolated Cu2+…