Search results for "biliary"

showing 10 items of 238 documents

Primary Biliary Cholangitis management: controversies, perspectives, and daily practice implications from an expert panel

2020

Primary biliary cholangitis (PBC) is a rare progressive immune-mediated liver disease that, if not adequately treated, may culminate in end-stage disease and need for transplantation. According to current guidelines, PBC is diagnosed in the presence of antimitochondrial antibodies (AMA) or specific antinuclear antibodies, and of a cholestatic biochemical profile, while biopsy is recommended only in selected cases. All patients receive ursodeoxycholic acid (UDCA) in first line; the only registered second-line therapy is obeticholic acid (OCA) for UDCA-inadequate responders. Despite the recent advances in understanding PBC pathogenesis and developing new treatments, many grey areas remain. Si…

medicine.medical_specialtyPopulationReceptors Cytoplasmic and NuclearDiseaserisk stratificationfibrates; liver biopsy; management; obeticholic acid; primary biliary cholangitis; risk stratificationprimary biliary cholangitiBile Acids and Salts03 medical and health scienceschemistry.chemical_compoundLiver disease0302 clinical medicineobeticholic acidBiopsymedicineHumansIntensive care medicineeducationliver biopsyeducation.field_of_studyCholestasisfibrateHepatologymedicine.diagnostic_testbusiness.industryprimary biliary cholangitisLiver Cirrhosis BiliaryUrsodeoxycholic AcidObeticholic acidmedicine.diseaseUrsodeoxycholic acidBile Acids and SaltTransplantationchemistryCholestasi030220 oncology & carcinogenesisLiver biopsy030211 gastroenterology & hepatologyfibratesbusinessmanagementmedicine.drugHuman
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An unusual case of postcholecystectomy syndrome.

2019

medicine.medical_specialtyPostcholecystectomy syndromemedicine.medical_treatmentMEDLINEYoung AdultImaging Three-DimensionalPancreaticobiliary MaljunctionmedicineHumansRadiology Nuclear Medicine and imagingCholangiopancreatography Endoscopic RetrogradeUnusual casemedicine.diagnostic_testbusiness.industryGeneral surgeryGastroenterologyCystic DuctMagnetic resonance imagingmedicine.diseaseMagnetic Resonance ImagingCholecystectomy LaparoscopicCholedochal CystCholecystectomyFemalebusinessPostcholecystectomy SyndromeGastrointestinal endoscopy
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HLA DRw8 and primary biliary cirrhosis

1992

medicine.medical_specialtyPrimary biliary cirrhosisHepatologybusiness.industryInternal medicineGastroenterologymedicineHuman leukocyte antigenbusinessmedicine.diseaseGastroenterologyGastroenterology
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PRIMARY BILIARY CIRRHOSIS AND CŒLIAC DISEASE

1978

medicine.medical_specialtyPrimary biliary cirrhosisbusiness.industryInternal medicinemedicineGeneral MedicineDiseasemedicine.diseasebusinessGastroenterologyThe Lancet
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Autoimmunhepatitis und Overlap-Syndrom: Therapie

2002

Die autoimmune Hepatitis (AIH), die primär biliäre Zirrhose (PBC) und die primär sklerosierende Cholangitis (PSC) werden zum Formenkreis der autoimmunen Lebererkrankungen gezählt. Bei diesen Lebererkrankungen spielen Immunreaktionen gegen wirtseigene Antigene eine herausragende pathogenetische Rolle. Lediglich für die AIH ist die autoimmune Ätiologie hinreichend belegt, während für die anderen beiden Erkrankungen zwar Autoimmunphänomene beschrieben wurden, jedoch die Rolle weiterer konditionierender Faktoren und infektiöser Agenzien weiter zu klären sind. Die Autoimmunhepatitis hat unbehandelt eine ungünstige Prognose und muss deshalb so früh wie möglich diagnostiziert und behandelt werden…

medicine.medical_specialtyPrimary biliary cirrhosisbusiness.industryInternal medicinemedicine.medical_treatmentmedicineImmunosuppressionGeneral MedicineAutoimmune hepatitismedicine.diseasebusinessGastroenterologyPrimary sclerosing cholangitisPraxis
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Endoscopic radiofrequency ablation of a cholangiocarcinoma with targeted intraductal cholangioscopic access.

2020

medicine.medical_specialtyRadiofrequency Ablationbusiness.industryRadiofrequency ablationGastroenterologyMEDLINElaw.inventionCholangiocarcinomaBiliary Tract Surgical ProceduresBile Ducts IntrahepaticBile Duct NeoplasmslawCatheter AblationMedicineHumansRadiologybusinessEndoscopy
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The starry sky liver: multiple biliary hamartomas on MR cholangiopancreatography

2018

The starry sky liver: multiple biliary hamartomas on MR cholangiopancreatography

medicine.medical_specialtyRadiological and Ultrasound Technologybusiness.industryCholangiopancreatography Magnetic ResonanceUrologyHamartomaLiver DiseasesGastroenterologyMultiple biliary hamartomasHepatology030218 nuclear medicine & medical imagingMr cholangiopancreatographyDiagnosis Differential03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingRadiologybusiness
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A scoring system for biliary atresia: Is this the right one?

2014

medicine.medical_specialtyScoring systemHepatologyBiliary atresiabusiness.industryGastroenterologymedicinemedicine.diseasebusinessSurgeryDigestive and Liver Disease
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Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice

2012

Background & Aims CYLD is a tumor suppressor gene that is mutated in familial cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. Reduced CYLD expression has been observed in other tumor entities, including hepatocellular carcinoma. In the present study, we analyzed the role of CYLD in liver homeostasis and hepatocarcinogenesis in vivo . Methods Mice with liver-specific deletion of CYLDexon7/8 ( CYLD FF xAlbCre ) were generated. Liver tissues were histologically analyzed and oval cell activation was investigated. Hepatocarcinogenesis was induced by diethylnitrosamine/phenobarbital (DEN/PB). Microarray expression profiling of livers was performed in untreated …

medicine.medical_specialtyTumor suppressor geneBiliary Tract DiseasesIn Vitro TechniquesBiologymedicine.disease_causeDimethylnitrosamineDeubiquitinating Enzyme CYLDMiceRisk FactorsFibrosisInternal medicinemedicineAnimalsHomeostasisGenetic Predisposition to DiseaseHepatologyLiver NeoplasmsExonsTransforming growth factor betamedicine.diseaseFibrosisMice Mutant StrainsDeubiquitinating Enzyme CYLDMice Inbred C57BLGene expression profilingCysteine EndopeptidasesDisease Models AnimalPhenotypeEndocrinologyLiverPhenobarbitalHepatocellular carcinomaCancer researchbiology.proteinCell activationCarcinogenesisGene DeletionJournal of Hepatology
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Extrakorporale Stoßwellenlithotripsie von Gallenblasensteinen: Wie viele Patienten sind geeignet?

2008

The proportion of patients with gallbladder stones suitable for extracorporeal shockwave lithotripsy (ESWL) was analysed prospectively in 200 patients aged 17-76 years (62 males, 138 females) with symptomatic cholecystolithiasis. Criteria for inclusion were clinical symptoms, solitary stones (diameter 10-30 mm) or up to three stones with comparable total volume, contractile gallbladder, no calcification of stones, normal biliary tract anatomy. To check these criteria a step-by-step diagnostic procedure was instituted which consisted of history, ultrasonography with contractility test, abdominal X-ray film, computed tomography measurement of stone density, and endoscopic retrograde cholangio…

medicine.medical_specialtybusiness.industryGallbladdermedicine.medical_treatmentGeneral MedicineGallstonesGallbladder StoneLithotripsymedicine.diseaseContractilitymedicine.anatomical_structureBiliary tractmedicineRadiologyProspective cohort studybusinessCalcificationDMW - Deutsche Medizinische Wochenschrift
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