Search results for "binders"
showing 3 items of 13 documents
MADoSPRO: a new approach to molecular modelling studies on a series of DNA minor groove binders
2006
The aim of this work was devoted to develop a method to predict Delta G values for a series of minor groove binders. Starting from a matrix of docking dataset for 10 minor groove binders (known and not) to 20 DNA fragments, with various sequences, it was possible to analyze the interaction modes and to calculate the Delta G value for new derivatives through MADoSPRO procedure. The method allowed, through the QSPR analysis, to characterize the type of interactions in such complexes, that was demonstrated to be related to quantum chemical and electrostatic descriptors, in agreement with the information available in literature on the structural requirements of specific minor groove ligands. Mo…
NEW APPLICATIONS IN THE USE OF CELLULOSE PULP FOR THE INTEGRATION OF WOODEN SUPPORTS
2017
Cellulose pulp, mainly utilized as a support for cleaning stone material, in this study, is proposed as a filler for wooden supports. In the last 10 years, pulp has been used in many restoration works carried out in the laboratory of the Diocesan Museum (MDP) in Palermo, including both wooden sculptures and panel paintings. These artworks, exhibited in the MDP, are constantly monitored in order to evaluate the effectiveness of cellulose pulp as a filler, assessing its durability and bio-receptivity. In particular, structural characteristics, drying time, shrinkage, loss in weight, affinity to the pigments, etc., were simultaneously evaluated. Tests were also carried out on artificially aged…