Search results for "bio-imaging"

Fluorescent naphthalimide-imidazolium hydrogels for biomedical applications

2019

Bioimaging and in vivo imaging are cornerstone technologies in support of biomedical diagnosis. However, in some cases imaging methods have increased cancer risks for patients. Moreover, the most widely used diagnostic medical imaging technique, X-ray imaging, is the largest man-made source of radiation exposure to the general population. Thus, the research of new efficient and less invasive materials for imaging is quite urgent. Supramolecular hydrogels have recently proved to be promising biological carriers to load versatile bioimaging agents for in vitro or in vivo bioimaging, thanks to the ability to undergo reversible swelling and gel–sol transition in response to various physiologica…

RADIATION-ENGINEERED NANOGELS AS GADOLINIUM VECTORS IN BIO-IMAGING

2014

Polymeric and bio-hybrid nanovectors for drug delivery and imaging devices.

2014

Nanotechnology applied to the Medicine is providing new tools to the current therapeutic and diagnostic approaches to fight cancer and other diseases. However, many of the proposed nanodevices show some deficits related to both their inherent properties and performance, and the synthetic strategies proposed for their production. In the present work, a new promising approach based on e-beam radiation-induced radical crosslinking of a water soluble, biocompatible synthetic polymer has been developed. In particular, the possibility of generating Poly-N-(Vinyl- Pyrrolidone)(PVP)-based nanocarriers, i.e. nanogels with a base PVP structure, tailored physico-chemical properties (particles size dis…

Bio-imaging with the helium-ion microscope: A review

2021

Scanning helium-ion microscopy (HIM) is an imaging technique with sub-nanometre resolution and is a powerful tool to resolve some of the tiniest structures in biology. In many aspects, the HIM resembles a field-emission scanning electron microscope (FE-SEM), but the use of helium ions rather than electrons provides several advantages, including higher surface sensitivity, larger depth of field, and a straightforward charge-compensating electron flood gun, which enables imaging of non-conductive samples, rendering HIM a promising high-resolution imaging technique for biological samples. Starting with studies focused on medical research, the last decade has seen some particularly spectacular …