Search results for "bioimaging."
showing 10 items of 16 documents
A gas ionisation Direct-STIM detector for MeV ion microscopy
2015
Abstract Direct-Scanning Transmission Ion Microscopy (Direct-STIM) is a powerful technique that yields structural information in sub-cellular whole cell imaging. Usually, a Si p-i-n diode is used in Direct-STIM measurements as a detector. In order to overcome the detrimental effects of radiation damage which appears as a broadening in the energy resolution, we have developed a gas ionisation detector for use with a focused ion beam. The design is based on the ETH Frisch grid-less off-axis Geiger–Muller geometry. It is developed for use in a MeV ion microscope with a standard Oxford Microbeams triplet lens and scanning system. The design has a large available solid angle for other detectors …
Naphthalimide imidazolium-based supramolecular hydrogels as bioimaging and theranostic soft materials
2020
1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures. Only salts having longer alkyl chains were able to give supramolecular hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheology measurements. Morphological information was obtained by scanning electron microscopy. In addition, conductive properties of organic salts in solution and gel state we…
Fluorescent supramolecular hydrogels for biomedical applications
2019
New supramolecular fluorescent NDI-gels as bioimaging materials
Single Heteroatom Fine-Tuning of the Emissive Properties in Organoboron Complexes with 7-(Azaheteroaryl)indole Systems
2016
The application of organoboron compounds as light-absorbing or light-emitting species in areas as relevant as organic electronics or biomedicine has motivated the search for new materials which contribute to the progress of those applications. This article reports the synthesis of four-coordinate boron complexes based on the unexplored 7-(azaheteroaryl)indole ligands. An easy synthetic approach has enabled the fine-tuning of the electronic structure of the organoboron species by modifying a heteroaromatic component in the conjugated system. Furthermore, a comprehensive characterization by X-ray diffraction, absorption and emission spectroscopy, both in solution and in the solid state, cycli…
Upconversion Nanoparticles for Bioimaging and Regenerative Medicine.
2016
Nanomaterials are proving useful for regenerative medicine in combination with stem cell therapy. Nanoparticles can be administrated and targeted to desired tissues or organs and subsequently, be used in non-invasive real-time visualization and tracking of cells by means of different imaging techniques, they can act as therapeutic agent nanocarriers, and can also serve as scaffolds to guide the growth of new tissue. Nanoparticles can be of different chemical nature, such as gold, iron oxide, cadmium selenide, and carbon, and have the potential to be used in regenerative medicine. However, there are still many issues to be solved, such as toxicity, stability, and resident time. Upconversion …
Idrogel fluorescenti per applicazioni biomediche
2019
Lo studio di idrogel supramolecolari da utilizzare in ambito biomedico è in continua espansione. Questo è dovuto al fatto che, così come gli idrogel polimerici, mostrano eccellenti proprietà meccaniche, ma possono anche essere sottoposti reversibilmente a rigonfiamento o a transizioni gel-sol in risposta a stimoli esterni (temperatura, pH, enzimi, agenti redox).1Ad esempio, la buona risposta degli idrogel supramolecolari agli stimoli fisiologici, insieme alla loro elevata biodegradabilità e biocompatibilità, ne ha permesso l’utilizzo per la diagnosi tumorale. Solitamente, questi materiali sono facilmente assimilati dalle cellule e hanno la funzione di carrier per le molecole attive nel bioi…
Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids
2014
Inorganic Janus particles for biomedical applications.
2014
Based on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well as composite organic–inorganic compounds. Janus particles are interconnected by solid state interfaces and, therefore, are distinguished by two physically or chemically distinct surfaces. They may be, for instance, hydrophilic on one side and hydrophobic on the other, thus, creating giant amphiphiles revealing the endeavor of self-assembly. Novel optical, electronic, magnetic, and superficial pro…