Search results for "blas"
showing 10 items of 2217 documents
Biological Description of 109 Cases of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) from the French Network of BPDCN
2015
Abstract Blastic plasmacytoid dendritic cell neoplasm is a clonal disease derived from precursors of plasmacytoid dendritic cells (pDC). It is a rare neoplasm involving the skin which may or may not be associated from the outset with a leukemic component. The disease invariably progresses to aggressive leukemic dissemination, leading to a differential diagnosis with acute leukemia. In 2004, we set up a French network to recruit biological data at diagnosis. Diagnosis was according to recommendations (Swerdlow et al, 2008), with, in addition, a mandatory panel of pDC markers (Garnache-Ottou et al, 2009) detected by flow cytometry or by immunohistochemistry on infiltrated blood, bone marrow o…
2015
The clarification of complete cell lineages, which are produced by specific stem cells, is fundamental for understanding mechanisms, controlling the generation of cell diversity and patterning in an emerging tissue. In the developing Central Nervous System (CNS) of Drosophila, neural stem cells (neuroblasts) exhibit two periods of proliferation: During embryogenesis they produce primary lineages, which form the larval CNS. After a phase of mitotic quiescence, a subpopulation of them resumes proliferation in the larva to give rise to secondary lineages that build up the CNS of the adult fly. Within the ventral nerve cord (VNC) detailed descriptions exist for both primary and secondary lineag…
Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentra…
2016
Cribra orbitalia (CO), or porotic hyperostosis (PH) of the orbital roof, is one of the most common pathological conditions found in archaeological subadult skeletal remains. Reaching frequencies higher than 50% in many prehistoric samples, CO has been generally attributed to a variety of factors including malnutrition (e.g., megaloblastic anemia) and parasitism. In this study, we tested the relationship between CO, trace element concentrations, and stable isotope values (δ13C, δ15N, δ18O) in subadult skeletons from a 17th to 18th century cemetery in the historic town of Jēkabpils, Latvia. A total of 28 subadults were examined, seven of which (25%) showed evidence of CO. Bioarchaeological ev…
Tres tablas más que añadir al catálogo de Vicente Macip. (Albaida, h. 1468- Valencia, 1551)
2013
Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study
2021
Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant copy number alterations (CNAs), single nucleotide variants (SNVs), and polymorphisms (SNPs) that were then combined into an integrated analysis. Spontaneously formed 3D tumoroids obtained from the recurrent mass have also been characterized. The results prove the power of combining C…
Retinoic-Acid-Induced Downregulation of the 67 KDa Laminin Receptor Correlates with Reduced Biological Aggressiveness of Human Neuroblastoma Cells
2012
Neuroblastoma is a common tumor of the childhood arising from embryonal sympathetic neural cell precursors. Despite of the improved therapeutic strategies, the survival rate of high-risk neuroblastoma patients is poor. Although complete clinical remissions can be achieved, relapse is relatively frequent, indicating a role for the persistence of the minimal residual disease (for review, Maris, 2010). Treatments with derivatives of retinoic acid (RA), the biologically active form of vitamin A, produce significant improvements on the therapy of high-risk neuroblastoma patients, when used together with intensive multimodal therapies (Reynolds et al., 2003, for review). Despite some controversy …
A subset of flavaglines inhibits KRAS nanoclustering and activation.
2020
The RAS oncogenes are frequently mutated in human cancers and among the three isoforms (KRAS, HRAS and NRAS), KRAS is the most frequently mutated oncogene. Here, we demonstrate that a subset of flavaglines, a class of natural anti-tumour drugs and chemical ligands of prohibitins, inhibit RAS GTP loading and oncogene activation in cells at nanomolar concentrations. Treatment with rocaglamide, the first discovered flavagline, inhibited the nanoclustering of KRAS, but not HRAS and NRAS, at specific phospholipid-enriched plasma membrane domains. We further demonstrate that plasma membrane-associated prohibitins directly interact with KRAS, phosphatidylserine and phosphatidic acid, and these int…
Sobre la vegetación de la alianza Homalothecio-Polypodion serrati en las montañas valencianas
1983
Se han estudiado las comunidades de la alianza Homalothecio-Polypodion serrati en las montañas de la región valenciana y alrededores, encontrándose que las mismas pueden atribuirse a cuatro asociaciones: Anomodonio-Polypodietum serrati, Saxifragetum cossonianae, Saxifragetum latepetiolatae y Homalothecio-Asplenietum fontani. Se presentan sendas tablas fitosociológicas de cada una de las tres últimas, de las cuales se comentan, asimismo, sus principales notas características. The communities included in the alliance Homalothecio-Polypodio serrati are studied in Valencia region and neighbouring areas. 4 associations can be assigned to them: Anomodonio-Polypodietum serrati, Saxifragetum cosson…
Análisis digital del infiltrado inmune en neuroblastoma. Impacto pronóstico.
2018
El neuroblastoma es el tumor sólido extracraneal más común en la niñez con un índice de supervivencia a los cinco años del 40% en pacientes de riesgo elevado a pesar de terapias intensivas. Recientemente, aunque la inmunoterapia, incluida la terapia de células T con receptor de antígeno quimérico, representa un tratamiento revolucionario para las neoplasias hematológicas, sigue habiendo grandes desafíos para aplicar esta estrategia terapéutica con los tumores sólidos, incluido el neuroblastoma, como resultado de la naturaleza inmunosupresiva del microambiente tumoral. Se ha descrito que las células cancerosas desarrollan múltiples mecanismos para escapar del reconocimiento inmune o para mod…
Estudios sobre los problemas ternarios de probabilidad condicional de nivel N0
2014
Esta tesis aborda el problema de la enseñanza y aprendizaje de la probabilidad condicional, desde la resolución de problemas. Concretamente nos interesamos por una familia particular de problemas, que denominamos problemas ternarios de probabilidad condicional de nivel N0 y que se caracterizan por no presentar ninguna probabilidad condicional como dato conocido en el enunciado. Los objetivos concretos de la tesis son tres: primero, profundizar en el estudio de la estructura matemática de los problemas ternarios de nivel N0; segundo, observar la actuación de un grupo de nueve estudiantes cursando la asignatura Matemáticas Opción B de 4º de ESO resolviendo problemas de nivel N0; y tercero, di…