Search results for "block"
showing 10 items of 1177 documents
Strategies, Technologies and Novel Components for the Architectural Integration of Photovoltaics
2015
La ricerca riguarda l'integrazione architettonica del fotovoltaico (FV) per il retrofit energetico del patrimonio edilizio esistente e la costruzione di edifici a energia zero (ZEB). L'obiettivo è lo studio e la successiva definizione di strategie, tecnologie e componenti innovativi per l'involucro edilizio che integrino il fotovoltaico, con particolare attenzione verso le tecnologie fotovoltaiche di nuova generazione. Il lavoro si concentra anche sull'ottimizzazione energetica e sull'analisi delle prestazioni di un componente innovativo per il BIPV (Building Integrated Photovoltaics, letteralmente fotovoltaico integrato negli edifici) utile alla costruzione di involucri edilizi sostenibili…
The assessment of the reliability of an innovative 3rd generation solar cell integrated with “thermal belt” glass block
2017
Glass block is a building product widely used for the construction of translucent building façades and roofs. The need to adapt the product to the regulations in the field of energy saving and environmental sustainability has led to the design of innovative configurations, through the integration of different sub-components. These ones are able to improve its energy performance by means of the integration of a“thermal belt”, cold glued to the glass shells, which constitute the traditional glass block, and 3rd generation solar cells. This paper reports the first results of the experimental program designed to assess some durability components: inherent and critical reliability. <div id="g…
Analysis and Performance Evaluation of the IEEE 802.16 ARQ Mechanism
2008
The IEEE 802.16 standard defines the ARQ mechanismas a part of the MAC layer. The functioning of the ARQmechanism depends on a number of parameters. The IEEE802.16 specification defines them but it does not provide concrete values and solutions. This paper studies the key features and parameters of the 802.16 ARQ mechanism. In particular, we consider a choice for the ARQ feedback type, an algorithm to build block sequences, the ARQ feedback intensity, a scheduling of the ARQ feedbacks and retransmissions, the ARQ block rearrangement, ARQ transmission window and the ARQ block size. We ran simulation scenarios to study these parameters and how they impact the performance of application protoc…
Trial Watch: Adoptively transferred cells for anticancer immunotherapy
2017
IF 7.719; International audience; Immunotherapies aimed at strengthening immune effector responses against malignant cells are growing at exponential rates. Alongside, the impressive benefits obtained by patients with advanced melanoma who received adoptively transferred tumor-infiltrating lymphocytes (TILs) have encouraged the scientific community to pursue adoptive cell transfer (ACT)-based immunotherapy. ACT involves autologous or allogenic effector lymphocytes that are generally obtained from the peripheral blood or resected tumors, expanded and activated ex vivo, and administered to lymphodepleted patients. ACT may be optionally associated with chemo- and/or immunotherapeutics, with th…
Responsiveness to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade in SB28 and GL261 mouse glioma models.
2018
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contrasting with treatment sensitivity of the more highly mutated GL261. Moreover, SB28 shows features of a poorly immunogenic tumor, with low MHC-I expression and modest CD8(+) T-cell infiltration, suggest…
Management of a patient with multiple device replacements and extractions: When the leadless pacemaker is a viable solution
2022
Leadless pacemaker (LPs) is a safe device and the implantation rates of this device is increasing. The device extraction and replacement are today a challenging procedures especially in case of infections, fragile and older patients or in unfavorable venous anatomy; LPs can be a valid alternative strategy in these cases. We report a case of management of a patient with multiple previous device replacements and extractions, with malfunction of transvenous pacemaker and with a fibrous membrane between the walls of the ventricular lead and the superior vena cava (SVC), who underwent a successful LP implantation.
ICO Crowdfunding: Incentives, Pricing Strategy, Token Strategy and Crowd Involvement
2020
AbstractBlockchain technologies provide means to develop services that are secure, transparent and efficient by nature. Unsurprisingly, the emerging business opportunities has gained a lot of interest that is realized in form of successful Initial Coin Offerings (ICOs) that are able to raise billions of USD through crowdfunding campaign. In this exploratory research we study 91 ICOs through content analysis in order to investigate the special characteristics of ICO crowdfunding as business models towards the possible investors. We found that ICOs can be described through (1) the model for providing incentives for investment, (2) the pricing strategy, (3) the token strategy and (4) the activ…
What Key Aspects Do ICOs Reveal About Their Businesses?
2020
AbstractBlockchain technologies disrupt industries by enabling decentralized and transactional data sharing across a network of untrusted participants, among others. Initial Coin Offerings (ICOs) are a novel form of crowdfunding through which hundreds of blockchain-enabled businesses manage to raise billions of dollars in total only in United States. However, there is a lack of understanding of the ICO phenomenon especially related to the business aspects. In this paper, we describe the results of an exploratory study of 91 ICOs and identify the key business model elements that ICOs reveal in their websites and whitepapers. Furthermore, we also note the immaturity and lack of transparency o…
Blockchain jako platforma logistyki publicznej
2020
Zarządzający sektorem publicznym coraz częściej poszukują nowych możliwości oferowania mieszkańcom większego pakietu świadczeń, przyczyniających się do podniesienia jakości życia. Jedną z ich jest logistyka publiczna, która posiada potencjał integracji i koordynacji działań w zakresie realizacji zadań publicznych. Jednak obawy sektora publicznego względem prywatnego wykonawstwa świadczeń ciągle jeszcze są stosunkowo duże. Wynika to nie tylko z braku zaufania do zewnętrznego wykonawstwa zadań, ale także z braku transparentności relacji między sektorem publicznym i prywatnym, znajdującym uzasadnienie w teorii agencji. Sposobem na poprawę relacji i optymalizację oferty w mieście może stanowić …
SPH modeling of blood flow in cerebral aneurysms
Gli aneurismi cerebrali sono dilatazioni patologiche di arterie cerebrali. Queste patologie hanno un intrinseco rischio di rottura con conseguenti emorragie intracraniche. Sebbene i meccanismi di formazione, crescita e rottura degli aneurismi cerebrali non sono ancora del tutto compresi, è comunemente riconosciuto che in questi processi i fattori emodinamici giocano un ruolo molto importante. Le simulazioni numeriche possono fornire utili informazioni sull'emodinamica e possono essere usate per applicazioni cliniche. Nei tradizionali metodi numerici basati su una griglia di calcolo il processo di discretizzazione dei vasi cerebrali sui quali insiste un aneurisma è molto complesso. D’altra p…