Search results for "board"
showing 10 items of 308 documents
Discovering hidden temporal patterns in behavior and interaction : t-pattern detection and analysis with THEME
2016
In our laboratories we use T-pattern analysis to study rat behavior in different and well-known experimental assays widely employed as rodent models of anxiety: the open field, the hole board and the elevated plus maze. By using Theme software and T-pattern analysis, we have observed that numerous events, characterizing rodent behavior in each experimental model, occurred sequentially and with significant constraints on the interval lengths separating them. In this chapter, for each test, we highlight some key aspects of our behavioral analyses, with a twofold attempt: first to provide the researcher with useful information concerning the application of T-pattern analysis in the study of ro…
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classificatio…
2016
AbstractThe IASLC Staging and Prognostic Factors Committee has collected a new database of 94,708 cases donated from 35 sources in 16 countries around the globe. This has now been analysed by our statistical partners at Cancer Research And Biostatistics and, in close collaboration with the members of the committee proposals have been developed for the T, N, and M categories of the 8th edition of the TNM Classification for lung cancer due to be published late 2016. In this publication we describe the methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition.
Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal
2020
Clinicians in molecular tumor boards (MTB) are confronted with a growing amount of genetic high-throughput sequencing data. Today, at German university hospitals, these data are usually handled in complex spreadsheets from which clinicians have to obtain the necessary information. The aim of this work was to gather a comprehensive list of requirements to be met by cBioPortal to support processes in MTBs according to clinical needs. Therefore, oncology experts at nine German university hospitals were surveyed in two rounds of interviews. To generate an interview guideline a scoping review was conducted. For visual support in the second round, screenshot mockups illustrating the requirements …
The role of internal corporate governance mechanisms on default risk: A systematic review for different institutional settings
2020
Recent financial downturns, characterized by the significant failures of firms, have revealed the need to control credit risk. Latest literature has shown that weak corporate governance structures are related to high levels of default risk, leading to financial instability. In this context, we aim to summarize the literature that focuses on the role that internal corporate governance plays in the credit risk of firms, specifically considering three corporate governance components: ownership structure, board structure and financial stakeholders’ rights and relations. Additionally, we analyse whether the effectiveness of the internal mechanisms depends on particular key factors, especially th…
Building a statistical surveillance dashboard for COVID-19 infection worldwide
2020
When a pandemic like the current novel coronavirus (COVID-19) breaks out, it is important that authorities, healthcare organizations and official decision makers, have in place an effective monitoring system to promptly analyze data, create new insights into problematic areas and generate actionable knowledge for fact-based decision making. The aim of this article is to describe an initial work focused on building a comprehensive statistical surveillance dashboard for the epidemic of COVID-19, which can be exploited also for future needs. We propose novel ways of exploring, analyzing and presenting data, using metrics that have not been used previously. We also show the steps necessary to b…
Sublimation of icy aggregates in the coma of comet 67P/Churyumov–Gerasimenko detected with the OSIRIS cameras on board Rosetta
2016
Beginning in 2014 March, the OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) cameras began capturing images of the nucleus and coma (gas and dust) of comet 67P/Churyumov¿Gerasimenko using both the wide angle camera (WAC) and the narrow angle camera (NAC). The many observations taken since July of 2014 have been used to study the morphology, location, and temporal variation of the comet's dust jets. We analysed the dust monitoring observations shortly after the southern vernal equinox on 2015 May 30 and 31 with the WAC at the heliocentric distance Rh = 1.53 AU, where it is possible to observe that the jet rotates with the nucleus. We found that the decline of brightness a…
The intensity contrast of solar photospheric faculae and network elements : II. Evolution over the rising phase of solar cycle 23
2006
We studied the radiative properties of small magnetic elements (active region faculae and the network) during the rising phase of solar cycle 23 from 1996 to 2001, determining their contrasts as a function of heliocentric angle, magnetogram signal, and the solar cycle phase. We combined near-simultaneous full disk images of the line-of-sight magnetic field and photospheric continuum intensity provided by the MDI instrument on board the SOHO spacecraft. Sorting the magnetogram signal into different ranges allowed us to distinguish between the contrast of different magnetic structures. We find that the contrast center-to-limb variation (CLV) of these small magnetic elements is independent of …
Ortodoncia lingual y ortodoncia vestibular: estudio comparativo de la selección de casos y la calidad de terminación
2017
Las malposiciones dentales tienen un impacto significativo sobre la estética de la sonrisa y, por tanto, se considera un factor clave que afecta de forma directa a la autoestima. El objetivo principal de un tratamiento de ortodoncia es conseguir una oclusión ideal, que sea morfológicamente estable a la vez que estética y funcional. El tratamiento de ortodoncia con aparatología fija se ha relacionado con algunos aspectos que condicionan la calidad de vida, desde el punto de vista de la salud bucodental, como problemas en la higiene oral, mayor dificultad en la pronunciación, mayor riesgo de aparición de lesiones de caries o mayores restricciones alimentarias. Estos efectos adversos se han re…
The relationship between organizational interdependency and additionality obtained from innovation ecosystem participation
2019
Abstract Despite the increased interest in innovation ecosystems, few studies have assessed the extent to which the proclaimed benefits from participating in such ecosystems also occur, and under which circumstances they do occur. Uniting the literature on organizational interdependence and social exchange theory, we assess the behavioral and output additionality obtained by innovation ecosystem participants. In doing so, we build upon a sample of 473 innovative Finnish companies, of which 312 participated in an innovation ecosystem. We find a significantly positive relationship between organizational interdependence and output additionality, and find that this relationship is mediated by b…
Clinical and Functional Studies Reveal That TP73 Isoforms Levels Are Associated with Prognosis and RA-Resistance in Acute Promyelocytic Leukemia
2019
Background: TP73 isoforms gained particular relevance in acute promyelocytic leukemia (APL) since Bernasola et al (JEM. 2004) demonstrated that TAp73 was directly regulated by the PML protein in the nuclear body. The isoforms differ in their transcriptional activity, with those lacking domains in the N-terminal part of the protein exerting a dominant negative effect on TP73 function. In a retrospective analysis of patients with APL treated in ICAPL study, Lucena-Araujo et al (Blood 2015) demonstrated the association between higher ΔNp73/TAp73 ratio values and poor clinical outcome. However,there is a diversity of TP73 isoforms and specially those lacking N-terminal domains (e.g.ΔEx2p73, ΔEx…