Search results for "bone"

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy

2017

Background: Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle degeneration and also high incidence of fractures. The aim of our study was to test whether inhibition of activin receptor IIB ligands with or without exercise could improve bone strength in the mdx mouse model for DMD. Methods: Thirty-two mdx mice were divided to running and non-running groups and to receive either PBS control or soluble activin type IIB-receptor (ActRIIB-Fc) once weekly for 7 weeks. Results: Treatment of mdx mice with ActRIIB-Fc resulted in significantly…

Reminiscing in white in Fae Myenne Ng's Bone

2018

The article focuses on the representation of whiteness in Fae Myenne Ng’s Bone (1993), in particular on how the aesthetic and the socio-historical strata of the novel intersect, how by saturating the imagery of Bone with whiteness, Ng conveys the first person Chinese American narrator’s positionality and the positionality of other Chinese American characters as members of the Chinese American community and members of broader American society. The images involving whiteness compose a kind of the palimpsest overwritten with personal and communal ethnic watermarks as well as repressed, surfacing and semi-articulated history of Leila’s family that she channels into the narrative, having engaged…

Comment on "Effects of Elastic Resistance Band Exercise on Postural Balance, Estrogen, Bone Metabolism Index, and Muscle Strength of Perimenopausal P…

2017

Text from the theory presentations and lists of objectives. General Anatomy

2022

El document ha sigut revisat pels tècnics del Servei de Política Lingüística, dins de la convocatòria 2021 dels Premis Fernando Sapiña a la qualitat lingüística en l'elaboració de materials docents en valencià i anglés. Text de les presentacions de les classes teòriques i llistes d'objectius de les classes de dissecció per a l'assignatura d'Anatomia General del grup en anglés (ARA) de primer curs del Grau en Medicina. Universitat de València Text from the presentations of the theory classes and lists of objectives of the dissection sessions for the subject of General Anatomy, in the English group (ARA) of the first year in the Degree of Medicine. Universitat de València

Barbed Dental Ti6Al4V Alloy Screw : Design and Bench Testing

2023

Background context. Dental implants are designed to replace a missing tooth. Implant stability is vital to achieving osseointegration and successful implantation. Although there are many implants available on the market, there is room for improvement. Purpose. We describe a new dental implant with improved primary stability features. Study design. Lab bench test studies. Methods. We evaluated the new implant using static and flexion–compression fatigue tests with compression loads, 35 Ncm tightening torque, displacement control, 0.01 mm/s actuator movement speed, and 9–10 Hz load application frequency, obtaining a cyclic load diagram. We applied variable cyclic loadings of prede…

Immunological micro and macroenvironment modifications for the early diagnosis and prognostication of breast and prostate adenocarcinomas

Root repair after injury from mini-screw

2005

Mini-implants and mini-screws are commonly used in orthodontics to provide extra anchorage. One potential insertion site is between the roots in the alveolar process, which results in a risk of damaging the roots of neighbouring teeth. In an animal-experimental study, 20 mini-screws (bracket screw bone anchors, BSBAs) were inserted into the mandible of five beagle dogs. Each dog received two BSBAs in each lower quadrant, between the roots of the second and third, and third and fourth premolars. Sequential point labelling was performed every 6 weeks with vital stains, and apical X-rays were taken every 6 weeks. Radiographic examination demonstrated damage at three roots because of insertion …

Investigation of inhibitory effects on EPC-mediated neovascularization by different bisphosphonates for cancer therapy.

2013

Bisphosphonates (BPs) are potent drugs, used in metastatic cancer-like prostate or breast carcinoma. In recent studies, besides reduced bone remodeling, influences on angiogenesis and neovascularization were reported. Since BPs have the tendency to accumulate in the bones, the biological effect of various nitrogen- and non-nitrogen BPs on endothelial progenitor cells (EPCs) that originated from bone marrow and mobilized under physiological and pathophysiological conditions, such as tumor neovascularization, was investigated. EPCs subsequent to 72-h treatment with different concentrations of bisphosphonates comprised the non-nitrogen-containing BP clodronate and the nitrogen-containing BPs i…

Spinal neuronal correlates of tapentadol analgesia in cancer pain: A back-translational approach

2014

Background Pain is a common and highly debilitating complication for cancer patients significantly compromising their quality of life. Cancer-induced bone pain involves a complex interplay of multiple mechanisms including both inflammatory and neuropathic processes and also some unique changes. Strong opioids are a mainstay of treatments but side effects are problematic and can compromise optimal pain control. Tapentadol is a novel dual-action drug, both stimulating inhibitory μ-opioid receptors (MOR) and mediating noradrenaline reuptake inhibition (NRI) leading to activation of the inhibitory α-2 adrenoceptor. It has been demonstrated to treat effectively both acute and chronic pain. We he…

Co-simulation platform based on systemc for multiprocessor system on chip architecture exploration

2007

Currently multiprocessor embedded systems are the principal vectors of semiconductor industry. Modelling, validating and analyzing a system performances impose the evolution of the traditional simulation techniques. In this paper we define the methodology we used in constructing the STARSoC co-simulation environment. This platform aims to explore at higher levels of abstractions a multiprocessors system on chip architectures. The platform reference design contains several OpenRISC 1200 Instruction Set Simulators (ISSs) wrapped under SystemC, and some basic peripherals within the SystemC simulation framework. Our purpose is to develop a complete design space exploration tool. In order to ass…