Search results for "borderline"
showing 10 items of 114 documents
Heterozygous deletion of the LRFN2 gene is associated with working memory deficits
2016
International audience; Learning disabilities (LDs) are a clinically and genetically heterogeneous group of diseases. Array-CGH and high-throughput sequencing have dramatically expanded the number of genes implicated in isolated intellectual disabilities and LDs, highlighting the implication of neuron-specific post-mitotic transcription factors and synaptic proteins as candidate genes. We report a unique family diagnosed with autosomal dominant learning disability and a 6p21 microdeletion segregating in three patients. The 870 kb microdeletion encompassed the brain-expressed gene LRFN2, which encodes for a synaptic cell adhesion molecule. Neuropsychological assessment identified selective w…
Violent offending in borderline personality disorder and attention deficit/hyperactivity disorder.
2018
Abstract The prevalence of borderline personality disorder (BPD) and attention deficit/hyperactivity disorder (ADHD) is significantly higher among offenders compared to the prevalence found in the general population. Both disorders share important diagnostic characteristics and thus it has been suggested that they might follow a common developmental pathway. In this narrative review, we first discuss the potential links of disorder inherent symptoms such as impulsivity and emotion regulation difficulties and how they might elevate the risk of violent delinquency. We continue with highlighting that comorbidities particularly from the antisocial spectrum as well as comorbid substance use diso…
Neuronal Cytoskeleton in Intellectual Disability: From Systems Biology and Modeling to Therapeutic Opportunities
2021
Intellectual disability (ID) is a pathological condition characterized by limited intellectual functioning and adaptive behaviors. It affects 1–3% of the worldwide population, and no pharmacological therapies are currently available. More than 1000 genes have been found mutated in ID patients pointing out that, despite the common phenotype, the genetic bases are highly heterogeneous and apparently unrelated. Bibliomic analysis reveals that ID genes converge onto a few biological modules, including cytoskeleton dynamics, whose regulation depends on Rho GTPases transduction. Genetic variants exert their effects at different levels in a hierarchical arrangement, starting from the molecular lev…
Gross motor proficiency and intellectual functioning
2018
This cross-sectional study examines differences in gross motor proficiency as a function of different intellectual functioning profiles. Two motor areas have been investigated as being equally essential to gross motor functions in every-day life: locomotion and object control. It aims to compare gross motor skills endorsed by children with Down syndrome (DS), children with borderline intellectual functioning (BIF), and typically developing children (TDC). Group 1 was composed of 18 children with DS (chronological age=8.22), group 2 was composed of 18 children with BIF (chronological age=9.32), and group 3 was composed of 18 children with typical development (TD) (chronological age=9.28). Gr…
Employers’ attitudes towards labour inclusion of persons with borderline intellectual functioning (BIF): An empirical evidence
2020
In the vocational rehabilitation of persons with disabilities (BIF), the need to consider the variables related to employer demand is increasingly becoming an important research topic. This empirical research explores the perceptions and attitudes of employers in hiring and retaining people with borderline intellectual functioning (BIF). For this purpose, the Metaplan procedure was used and a focus group was conducted in small and medium enterprises (SMEs) of the Spanish Vinalopó Footwear Cluster. Results showed a significant lack of knowledge and visibility of people with BIF. Lack of financial support to encourage hiring was pointed out by participants in the group as the most relevant ba…
“Dissociation, posttraumatic stress symptoms, emotional dysregulation, and invalidating environments as correlates of NSSI in borderline personality …
2020
Theoretical models have proposed that inadequate caregiving environments undermine the development of adaptive regulation strategies at early stages and can lead children to inadequate regulation skills for coping with distress, such as dissociation, posttraumatic stress, and NSSI. The main aim of this work was to examine NSSI types and functions and the relationship between the aforementioned variables and lifetime NSSI in 102 patients with BPD diagnoses or BPD subthreshold symptoms. In addition, we explored the moderator role of dissociation between invalidating environments and NSSI. Results showed that 83.7% of the sample self-injured more than 5 times during their lifetime; 62.7% swall…
Psychometric Properties of the Spanish Version of the Nonattachment Scale (NAS) and Its Relationship with Mindfulness, Decentering, and Mental Health
2016
Abstract Nonattachment is a Buddhism-rooted construct, which can be defined as the relative absence of fixation on ideas, images, or sensory objects, as well as an absence of internal pressure to get, hold, avoid, or change circumstances or experiences. The present study was aimed at exploring the psychometric properties of the Spanish version of the Nonattachment Scale (NAS) and at delimitating the relationship between the NAS and measures of mindfulness, decentering, and negative emotional symptoms. Pooling the NAS data from Spanish meditators (n = 335) and nonmeditators (n = 270), we performed an exploratory factor analysis and then estimated the fit of two competing models (one-factor m…
What Dimension of Meaning in Life is the Stronger Predictor of Borderline Personality Disorder Symptom?
2019
Researchers seem to view meaning in life as consisting of different dimensions: coherence, purpose, and significance. Meaning in life has been found to be a protective factor against several mental...
Childhood maltreatment, personality vulnerability profiles, and borderline personality disorder symptoms in adolescents.
2021
AbstractAdverse childhood experiences are significant risk factors in the development of adolescent borderline personality disorder symptoms (BPDs). Theorists have posited that two personality vulnerabilities factors, self-criticism and dependency, may inform our understanding of this relationship. However, no research has examined the associations between early negative experiences, personality vulnerabilities, and adolescent BPDs. The current study aimed to identify profiles of dependency and self-criticism to examine the associations of these profiles with cumulative forms of childhood maltreatment (CM) and BPDs as well as to explore the mediating and moderating role of vulnerable person…
Relationship between effortful control and facets of mindfulness in meditators, non-meditators and individuals with borderline personality disorder
2018
As dimensions of effortful control (EC), activation control, attentional control, and inhibitory control could mediate the relationship between mindfulness meditation practice and the facets of mindfulness (i.e., observing, describing, acting with awareness, non-judging and non-reacting to inner experience). In this study, we tested whether participant status: meditators (n = 330), healthy non-meditators (n = 254) and individuals with borderline personality disorder (BPD) diagnosis (n = 46) predicted the facets of mindfulness and if these potential effects were mediated through the three effortful control (EC) dimensions (activation, attentional and inhibitory control). Meditators scored hi…