Search results for "borderline"

Transgenerationale Effekte belastender Kindheitserlebnisse auf die Borderline-Symptomatik von Jugendlichen

2014

Einleitung: Bisherige Forschungsergebnisse belegen substantielle Zusammenhänge zwischen dem Erleben von Missbrauchs- und Misshandlungserfahrungen in der Kindheit und der Entwicklung der Borderline Persönlichkeitsstörung im Erwachsenenalter. Die Frage nach transgenerationalen Effekten belastender Kindheitserlebnisse sowie möglicher intermittierender Variablen wird hingegen kontrovers diskutiert. Zudem beschäftigten sich bislang wenige Studien mit der Entwicklung von Borderline Symptomen im Jugendalter. An diesen Wissenslücken ansetzend, untersuchen wir die spezifischen Effekte belastender Kindheitserfahrungen von Eltern auf Borderline-Persönlichkeitsmerkmale der Folgegeneration sowie möglich…

The catechol o-methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in fem…

2009

Wagner S, Baskaya O, Anicker NJ, Dahmen N, Lieb K, Tadic A. The catechol o‐methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). Objective: We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val158Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD). Method: One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss‐Durkee‐Hostility Inventory (BDHI). Result…

Caratteristiche di Personalità e Profili Anaclitici/Introiettivi di Adolescenti Borderline

2014

Il Disturbo Borderline di Personalità (DBP) in adolescenza occupa un ruolo centrale (Bradley, Conklin, & Westen, 2005), nonostante l’eterogeneità, la comorbidità e la difficile diagnosticabilità (Heitz et al., 2014). Diversi sono stati i tentativi di creare categorie discrete in grado di identificare profili di funzionamento della personalità sufficientemente omogenei (cfr. Wixom, Ludolph, & Westen, 1993; Blatt & Luyten, 2009). Nel nostro studio ci proponiamo di confermare l’esistenza di profili introiettivi/anaclitici all’interno dello spettro borderline. Sono stati somministrati a due gruppi di soggetti (clinico vs controllo) la Structured Clinical Interview for DSM-IV Axis II Disorders (…

Psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features-A systematic review of randomized clinical trials …

2021

Objectives To review the effectiveness of psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features. Methods We included randomized clinical trials on psychological therapies for adolescents with BPD and BPD features. Data were extracted and assessed for quality according to Cochrane guidelines, and summarized as mean difference (MD) with 95% confidence intervals (CI) for continuous data and as Odds ratios (OR) with 95% CI for dichotomous data. Risk of bias was assessed using Cochrane’s risk of bias tool for each domain. When possible, we pooled trials into meta-analyses, and used Trial Sequential Analysis (TSA) to control for random errors. Quality…

94. Extinction of cognitively conditioned fear in borderline personality disorder

2009

Evaluation of Borderline Ovarian Tumor Recurrence Rate after Surgery with or without Fertility-Sparing Approach: Results of a Retrospective Analysis

2023

Borderline ovarian tumors (BOTs) comprise 15-20% of primary ovarian neoplasms and represent an independent disease entity among epithelial ovarian cancers. The present study (Clinical Trial ID: NCT05791838) aimed to report a retrospective analysis of the management and outcomes of 86 consecutive BOTs patients, 54 of which were at a reproductive age. All patients with BOTs undergoing surgical treatment from January 2010 to December 2017 were included. Data were retrospectively reviewed. High levels of Ca-125 were observed in 25.6% of the FIGO stage I patients and 58.3% of the advanced disease patients. Fertility-sparing surgery and comprehensive surgical staging were performed in 36.7% and 4…

Cardiovascular risk in patients without known cardiovascular disease.

2014

Understanding the risks of atherosclerotic cardiovascular disease (CVD) allows for better patient education and management. Multiple risk models have been validated in large patient populations and provide insights into the risks associated with CVD. When assessing such risks, we suggest using a model that predicts myocardial infarction, cardiovascular death, and/or cerebrovascular events. In this review, we analyze several risk models and stratify the risks associated with CVD. We suggest that appropriate profiling of patients at-risk of CVD will lead to better physician recognition and treatment of modifiable risk factors, appropriate application of ATP III treatment for hyperlipidemia, a…

Exome sequencing in a child with neurodevelopmental disorder and epilepsy: Variant analysis of the AHNAK2 gene

2022

Background The AHNAK2 gene encodes a large nucleoprotein expressed in several tissues, including brain, squamous epithelia, smooth muscle, and neuropil. Its role in calcium signaling has been suggested and to date, clear evidence about its involvement in the pathogenesis of clinical disorders is still lacking. Methods Here, we report a female 24-year-old patient diagnosed with a cardio-facio-cutaneous-like phenotype (CFC-like), characterized by epilepsy, psychomotor development delay, atopic dermatitis, congenital heart disease, hypotonia, and facial dysmorphism, who is compound heterozygote for two missense mutations in the AHNAK2 gene detected by exome sequencing. Results This patient had…

The role of depression and impulsivity in the psychopathology of bulimia nervosa.

2013

Introduction: The study aimed to analyze the role of depression and impulsivity in the psychopathology of bulimia nervosa (BN). Materials and methods: Seventy female patients with DSM-IV BN, purging subtype, were assessed for eating-related symptoms, body dissatisfaction, affective symptoms, impulsivity, and personality traits. Factor analysis and structural equation modeling methods were used for statistical analysis. Results: BN appeared as a condition which incorporated 5 general dimensions: a) binge eating and compensatory behaviours; b) restrictive eating; c) body dissatisfaction; d) dissocial personality traits; and e) a cluster of features which was called "emotional instability" The…

Emotion Regulation and Mentalization in Somatoform Disorders

2010

Alexithymia, characterized by deficits in the awareness and differentiation of emotional states, is hypothesized as underlying somatoform disorders. Mentalization as a construct investigated in cognitive psychology is defined as the ability to refer mental states of others in order to predict their behavior. Developmental psychologists claim that the ability to represent emotions mentally is the cornerstone for the emergence of mentalizing capacity. Therefore, linking alexithymia and mentalization, it is argued that patients with somatoform disorders may not only be hampered in their ability to be consciously aware of their emotions, but may also suffer from deficits in mentalizing capacity…