Search results for "bp"
showing 10 items of 672 documents
Myc Promoter-Binding Protein-1 (MBP-1) Is a Novel Potential Prognostic Marker in Invasive Ductal Breast Carcinoma
2010
BackgroundAlpha-enolase is a glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm. α-Enolase and the predominantly nuclear Myc promoter-binding protein-1 (MBP-1) originate from a single gene through the alternative use of translational starting sites. MBP-1 binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription. Although several studies have shown an antiproliferative effect of MBP-1 overexpression on several human cancer cells, to date detailed observations of α-enolase and MBP-1 relative expression in primary tumors versus normal tissues and their correlation with clinicopathological features ha…
A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and sibli…
2011
Item does not contain fulltext BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes. METHODS: Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a …
The frontier between cell and organelle: genome analysis of Candidatus Carsonella ruddii
2007
Background Bacterial symbioses are widespread among insects. The early establishment of such symbiotic associations has probably been one of the key factors for the evolutionary success of insects, since it may have allowed access to novel ecological niches and to new imbalanced food resources, such as plant sap or blood. Several genomes of bacterial endosymbionts of different insect species have been recently sequenced, and their biology has been extensively studied. Recently, the complete genome sequence of Candidatus Carsonella ruddii, considered the primary endosymbiont of the psyllid Pachpsylla venusta, has been published. This genome consists of a circular chromosome of 159,662 bp and…
Mucoadhesive Solid Lipid Microparticles (SLM) for sustained release of corticosteroids to the lungs
2016
Pulmonary delivery is the preferred route of drug administration in the treatment of many respiratory disease, such as asthma and chronic obstructive pulmonary disease (COPD). Over the years, several kinds of carriers have been studied for sustained release of corticosteroids and bronchodilators to the lungs. Solid Lipid Microparticles (SLM) due to their biocompatibility and size (3-5 µm) can reach the bronchial epithelium directly, circumvent first pass metabolism and avoid systemic toxicity [1,2]. In this work we describe the preparation and the characterization of two different systems subjected to chitosan and alginate coating for sustained release of fluticasone propionate (FP) into th…
Towards understanding the abundance of non-pollen palynomorphs : A comparison of fossil algae, algal pigments and sedaDNA from temperate lake sedimen…
2018
Given the increased interest in non-pollen palynomorphs (microscopic objects other than pollen identified from pollen slides) in palaeoecological studies, it is necessary to seek a deeper understanding of the reliability of these results. We combined quantitative information of algal pigments and sedimentary ancient DNA (sedaDNA) of phylotaxonomical resolution to validate the richness and abundance of fossil algae in the sediment of a small temperate lake. For the first time, fossil and sedaDNA algae data were combined in a composite data-set and used to reconstruct algae turnover rates over the last 14,500 years. This comparison serves as both an example of howfossil algae can be used to a…
Darbplūsmas uzskaites sistēma kompānijai "mint.lv"
2015
Šajā dokumentā aprakstītā kvalifikācijas darba mērķis ir izveidot vienkāršu darbplūsmas uzskaites sistēmu kompānijai SIA “Mint.lv. Izstrādātās sistēmas mērķis ir atvieglot kompānijas darbinieku un uzskaites ikdienu, padarot ērtāku darba atskaišu pievienošanu, apkopošanu un apstrādi. Izmantojot šo sistēmu, kompānijas darbiniekiem būs ērtāk pievienot atskaites par darbā paveikto un firmas vadībai būs vieglāk sekot līdzi darbinieku paveiktajam, aprēķināt dažādu projektu izmaksas un uzlabot projektu izstrādes kvalitāti. Sistēma izstrādāta kā tīmekļa vietne, izmantojot PHP, Javascript, HTML5, CSS, CodeIgniter satvaru, MySQL un jQuery bibliotēku.
The new course of FITs mechanism for PV systems in Italy: novelties, strong points and criticalities
2011
The paper deals with the new course of the Feed-in Tariffs mechanism for photovoltaic systems that will start from January 1, 2011 in Italy with the actuation of the Government Decree DM 06/08/2010. After a short introduction on Feed-in Tariffs and Net-metering in Italy, the paper focuses the attention on an economical comparison between the incentives established by the Government Decree DM 19/02/07, ended on December 31, 2010 and those introduced by the DM 06/08/2010. The economical comparison is based on three indexes: the Pay Back Period, the Net Present Value and the Internal Rate of Return, characterizing the investments done for the realization of the photovoltaic systems. In particu…
Insights into how nucleotide supplements enhance the peroxidase-mimicking DNAzyme activity of the G-quadruplex/hemin system
2012
Since the initial discovery of the catalytic capability of short DNA fragments, this peculiar enzyme-like property (termed DNAzyme) has continued to garner much interest in the scientific community because of the virtually unlimited applications in developing new molecular devices. Alongside the exponential rise in the number of DNAzyme applications in the last past years, the search for convenient ways to improve its overall efficiency has only started to emerge. Credence has been lent to this strategy by the recent demonstration that the quadruplex-based DNAzyme proficiency can be enhanced by ATP supplements. Herein, we have made a further leap along this path, trying first of all to deci…
Addressing subphthalocyanines and subnaphthalocyanines features relevant to fluorescence imaging
2018
International audience; A series of new synthetic subphthalocyanines bear structural features aimed at allowing either fluorescence activation or a bathochromic shift of the absorption band towards the near-infrared window, relevant to optical imaging. X-ray diffraction studies of four subphthalocyanines are reported. Spectrofluorimetric studies on subnaphthalocyanines and activatable subphthalocyanine pro-fluorophores are reported.