Search results for "bp"
showing 10 items of 672 documents
Nuclear Myc Promoter-Binding Protein-1 (MBP-1) Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma
2010
Identification of a prognostic gene signature associated with MBP-1 expression in ErbB2-negative breast carcinomas
2014
The ENO1 transcript, which encodes the glycolitic enzyme alpha-enolase, can be translated into a shorter nuclear protein called Myc-promoter Binding Protein-1 (MBP-1) by using an alternative translation start site. MBP-1 acts as a negative regulator of c-Myc, ErbB2 and Cox2 genes (1). Several evidences indicate that MBP-1 acts as a tumor suppressor in breast carcinoma and prostate cancer and its expression results in a reduced invasive ability (2). In our previous studies, we showed that MBP-1 is expressed and easily detectable in normal breast epithelial cells, but a loss of expression occurs in most primary invasive ductal carcinomas (IDC) of the breast. Furthermore, in these tumors MBP-1…
Relazione tra l’espressione del repressore trascrizionale MBP-1 e di miRNAs nel carcinoma mammario
2013
MBP-1 (Myc-promoter-binding-protein-1) è una proteina di 37 kDa, prodotta dalla traduzione alternativa del mRNA del gene ENO1, codificante per l’enzima glicolitico α-enolasi. MBP-1 svolge il ruolo di repressore trascrizionale agendo direttamente sul promotore di c-MYC, ERBB2 e COX2, tutti geni coinvolti in diverse fasi della progressione tumorale (1-3). Nei carcinomi duttali infiltranti della mammella (IDC), l’espressione di MBP-1 è inversamente correlata alla comparsa di metastasi linfonodali e di recidive (4). In diverse linee cellulari tumorali l’overespressione di MBP-1 risulta nella riduzione della proliferazione cellulare e dell’invasività e in un aumento nella morte cellulare per apo…
ONCOSUPPRESSOR ACTIVITY OF TRANSCRIPTIONAL REPRESSOR MBP-1 IN NEUROBLASTOMA LAN-5 CELLS
2014
MULTIOMIC ANALYSIS OF TRANSCRIPTIONAL REPRESSOR MBP-1 FUNCTIONS IN GYNECOLOGICAL TUMORS
2014
Nuclear myc promoter-binding protein-1 (MBP-1) expression is a prognostic factor in invasive ductal breast carcinoma
2010
Insulators are DNA elements that block the extension of a condensed chromatin domain into a transcriptionally active region or prevent the interaction of a distal enhancer with a promoter when placed between the two. Human c-Myc and Pvt-1 genes map close each other and are separated by an intergenic region rich of DNAseI hypersensitivity sites. Starting from the observation that PVT1 expression is restricted to a low number of normal tissues compared to the wide distribution of c-Myc mRNA we focus our studies on the function and structure of the regions surrounding the DHs present between the two genes. Stable and transient transfection, indicate that one of the regions (HB-2.8) has enhance…
A microRNA and mRNA signature of neuroblastoma LAN-5 cells expressing MBP-1
2014
SURFACE ROUGHNESS PREDICTION OF ELECTRO-DISCHARGE MACHINED COMPONENTS USING ARTIFICIAL NEURAL NETWORKS
2016
Electro-Discharge machining (EDM) is a thermal process comprising a complex metal removal mechanism, which involves the formation of a plasma channel between the tool and the workpiece electrodes leading to the melting and evaporation of the material to be removed. EDM is considered especially suitable for machining complex contours with high accuracy, as well as for materials that are not amenable to conventional removal methods. However, several phenomena negatively affecting the surface integrity of EDMed workpieces need to be taken into account and studied in order to achieve the optimization of the process. Recently, artificial neural networks (ANN) have emerged as a novel modeling tec…
I BBPR a Palermo tra innesti di modelli esogeni e influenze endogene
2021
Se vi è qualcosa di profondamente e visceralmente connaturato alla stessa dimensione esistenziale della città di Palermo, sin dalle sue molteplici e stratificate origini fenicio-puniche, questo è certamente il concetto di ‘innesto’. Ed in analogia con l’innesto agrario, cioè con la pratica del far concrescere in una pianta esistente una parte di un altro vegetale, al fine di rafforzare il primo soggetto ma modificandolo verso un genere diverso da quello iniziale, l’intera storia millenaria della città potrà essere riguardata come il frutto di continui, ciclici introduzioni di modelli architettonici e urbani esogeni, declinati rispetto alle contingenze culturali autoctone dei diversi esempi …