Search results for "bubble"
showing 10 items of 167 documents
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence.
2013
8-Oxoguanine (8-oxoG) is a major product of oxidative DNA damage, which induces replication errors and interferes with transcription. By varying the position of single 8-oxoG in a functional gene and manipulating the nucleotide sequence surrounding the lesion, we found that the degree of transcriptional inhibition is independent of the distance from the transcription start or the localization within the transcribed or the non-transcribed DNA strand. However, it is strongly dependent on the sequence context and also proportional to cellular expression of 8-oxoguanine DNA glycosylase (OGG1)-demonstrating that transcriptional arrest does not take place at unrepaired 8-oxoG and proving a causal…
8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1.
2011
The common DNA base modification 8-oxo-7,8-dihydroguanine (8-oxo-G) affects the efficiency and fidelity of transcription. We constructed plasmid substrates carrying single 8-oxo-G residues, specifically positioned in the transcribed or the non-transcribed DNA strands, to investigate their effects on the expression of an EGFP reporter gene and to explore the role of base excision repair in the mechanism of transcription inhibition. We report that 8-oxo-G does not directly block transcription in cells, since a single 8-oxo-G in the transcribed DNA strand did not reduce the EGFP expression levels in repair-deficient (OGG1-null) mouse embryonic fibroblast cell lines. Rather, inhibition of trans…
Non-supersymmetric AdS6 and the swampland
2021
We discuss infinite families of non-supersymmetric AdS$_6$ solutions in Type IIB string theory. They are siblings of supersymmetric solutions which are associated with $(p,q)$ 5-brane webs and holographically dual to 5d SCFTs engineered by those brane webs. The non-supersymmetric backgrounds carry identical 5-brane charges and are connected to the supersymmetric ones by RG flows. We study the stability of the non-supersymmetric solutions, identifying perturbative and non-perturbative decay channels for all the backgrounds explicitly available. We also identify likely decay mechanisms for solutions that have not been constructed explicitly but may be expected to exist based on brane web cons…
On AdS7 stability
2019
AdS$_7$ supersymmetric solutions in type IIA have been classified, and they are infinitely many. Moreover, every such solution has a non-supersymmetric sister. In this paper, we study the perturbative and non-perturbative stability of these non-supersymmetric solutions, focusing on cases without orientifolds. Perturbatively, we first look at the KK spectrum of spin-2 excitations. This does not exhibit instabilities, but it does show that there is no separation of scales for either the BPS and the non-BPS case, thus proving for supersymmetric AdS$_7$ a well-known recent conjecture. We then use 7d gauged supergravity and a brane polarization computation to access part of the spectrum of KK sc…
Skyrmion-number dependence of spin-transfer torque on magnetic bubbles
2015
We theoretically study the skyrmion-number dependence of spin-transfer torque acting on magnetic bubbles. The skymrion number of magnetic bubbles can take any integer value depending on the magnetic profile on its circumference and the size of the bubble. We find that the transverse motion of a bubble with respect to the charge current is greatly suppressed as the absolute value of the skyrmion number departs from unity, whereas the longitudinal motion is less sensitive.
Conduit dynamics and post explosion degassing on Stromboli: A combined UV camera and numerical modeling treatment.
2016
Abstract Recent gas flux measurements have shown that Strombolian explosions are often followed by periods of elevated flux, or “gas codas,” with durations of order a minute. Here we present UV camera data from 200 events recorded at Stromboli volcano to constrain the nature of these codas for the first time, providing estimates for combined explosion plus coda SO2 masses of ≈18–225 kg. Numerical simulations of gas slug ascent show that substantial proportions of the initial gas mass can be distributed into a train of “daughter bubbles” released from the base of the slug, which we suggest, generate the codas, on bursting at the surface. This process could also cause transitioning of slugs i…
Acoustic rendering of particle-based simulation of liquids in motion
2009
In interaction and interface design, the representation of continuous processes often uses liquid metaphors, such as dripping or streaming. When an auditory display of such processes is required, an approach to sound-synthesis based on the physics of liquids in motion would be the most convincing, especially when real-time interaction is into play. In order to bridge the complexity of fluid-dynamic simulations with the needs of interactive sonification, we propose a multi-rate sound synthesis of liquid phenomena. Low-rate smoothed-particle hydrodynamics is used to model liquids in motion and to trigger sound-emitting events. Such events, such as solid-liquid collision, or bubble formation, …
Numerical prediction of ventilated planing flat plates for the design of Air Cavity Ships
2017
In recent years, a great world issue is the respect for the environment. Each researcher, in his competence field, proposes new technologies and new approaches in order to reduce the environmental impact of a product or of an industrial process. In the naval field, the main way in order to reduce the environmental impact of the ship during the navigation is the reduction of the drag resistance and so the reduction of requested power. There are many ways in order to obtain a reduction of drag. This paper investigates, with a preliminary numerical study by means of Computational Fluid Dynamics (CFD), the Air Cavity Ships technology (ACS). A first part of the paper concerns the study of the ri…
Experimental study of bubble detection in liquid metal.
2017
International audience; Bubble detection in liquid metal is an important issue for various technological applications. For instance, in the framework of Sodium Fast Reactors design, the presence of gas in the sodium flow of the primary and secondary loops is an issue of crucial importance for safety and reliability. Here, the two main gas measurement methods in sodium are ultrasonic testing and eddy-current testing; we investigate the second method in our study. In a first approach, we have performed experiments with liquid metal galinstan containing insulating spherical beads of millimeter size. The liquid metal is probed with an Eddy-current Flowmeter (ECFM) in order to detect the beads a…
Bubbles in China
2010
This study examines rational bubbles in Chinese stock markets and China-related share indices in Hong Kong. A duration dependence test is employed for both monthly and weekly abnormal market returns of the Shanghai and Shenzhen A- and B-markets, as well as for the Hong Kong China Enterprises and China Affiliated Corporations indices. The test results are mixed, as weekly data demonstrate bubbles for all of the Mainland Chinese stock markets, but monthly data do not show bubbles for any of the examined markets. Neither of the datasets indicates bubbles in the Hong Kong markets. Results indicate that, in terms of bubbles, segmentation does not play a significant role in bubble existence and t…