Search results for "bula"

Predicción de riesgo de rechazo agudo en pacientes con trasplante renal

2009

Objective: Create a model to predict the risk of acute rejection of kidney transplant considering variables related to the immunosuppressant agent used, the receiver, the donor and the transplanted organ. Methods: Cohort study in a population of 68 patients with kidney transplants being treated with tacrolimus triple therapy. Predicting the risk of acute rejection was carried out with a logistic regression analysis using age, sex, re-transplant status, number of HLA incompatibilities, cold ischaemia time, acute tubular necrosis, induction with basiliximab or thymoglobulin and treatment type as explanatory variables. The contribution of variables associated with determining the blood concent…

Off-Label Prescriptions In Palliative Care Patients At Home Care Unit*

2015

Inestabilidad de la articulación tibio-peronea proximal como causa de dolor en artroplastia total de rodilla primaria.

2020

espanolLa inestabilidad de la articulacion tibio-peroneaproximal (ATPP) aislada como causa de dolor en una rodilla protetizada es una entidad clinica muy poco frecuente, hasta la fecha solo hemos encontrado una referencia en la bibliografia de inestabilidad ATPP asociada a Artroplastia total de rodilla. Revisamos la bibliografia sobre las diferentes formas de inestabilidad y su etiologia, asi como las posibilidades de tratamiento conservador y quirurgico. Presentamos el caso de un paciente con inestabilidad ATPP anterolateral asociada a una ATR primaria posteroestabilizada (PS) con platillo tibial movil. EnglishThe isolated instability of the proximal tibiofibular joint (PTFJ) as a cause of…

Increased Hospital Stay and Allograft Disfunction in Renal Transplant Recipients with Cyp2c19 AA Variant in SNP rs4244285

2012

Pharmacogenetics correlates certain genetic variants, such as single nucleotide polymorphisms (SNPs), with blood drug levels, efficacy, and adverse effects of the treatment. Tacrolimus is mainly metabolized via CYP3A4/5, whereas CYP2C19 and CYP3A4/5 are responsible for omeprazole metabolism. Omeprazole inhibits tacrolimus metabolism via CYP3A5 in patients carrying variant alleles of CYP2C19, increasing tacrolimus blood concentrations. Seventy-five renal transplant recipients treated with tacrolimus and concomitant omeprazole were genotyped in a panel of 37 SNPs with use of Sequenom MassArray. The patients with CYP2C19*2/*2 genotype (n = 4) showed a median posttransplantation hospital stay o…

Monitorización de la vacomicina en administración intraperitoneal en pacientes sometidos a diálisis peritoneal continua ambulatoria

2012

Objective: To validate a pharmacokinetic model of the treatments with intraperitoneal vancomycin applied to patients on continuous ambulatory peritoneal dialysis with bacterial peritonitis. Methods: To carry out a prospective study divided in 2 cohorts: the first one including ten patients of 56 ± 14 years and 65 ± 5 kg, and the second one with 10 patients (12 episodes of peritonitis) aged 52 ± 13 years and 64 ± 8 kg. The treatment consists of administering and retaining for 6 h in the peritoneal cavity a solution containing 2 g of vancomycin and 1 g of ceftazidime into 2 l of ‘‘dialysis solution’’. After the antibiotic administration, blood samples were obtained at 4, 6, 8, 10, 24, 48 and …

MIUSCAT: extended MILES spectral coverage - II. Constraints from optical photometry

2012

In the present work we show a comprehensive comparison of our new stellar population synthesis MIUSCAT models with photometric data of globular clusters and early-type galaxies. The models compare remarkably well with the colours of Milky Way globular clusters in the optical range. Likewise, the colours of M31 globular clusters can also be explained by the models by assuming younger ages then their Galactic counterparts. When compared with quiescent galaxies we reproduce the colour evolution at intermediate redshift. On the other hand we find that the colour relations of nearby early-type galaxies are still a challenge for present-day stellar population synthesis models. We investigate a nu…

Discovery of 105 Hz coherent pulsations in the ultracompact binary IGR J16597-3704

2018

We report the discovery of X-ray pulsations at 105.2 Hz (9.5 ms) from the transient X-ray binary IGR J16597-3704 using NuSTAR and Swift. The source was discovered by INTEGRAL in the globular cluster NGC 6256 at a distance of 9.1 kpc. The X-ray pulsations show a clear Doppler modulation implying an orbital period of ~46 minutes and a projected semi-major axis of ~5 lt-ms, which makes IGR J16597-3704 an ultra-compact X-ray binary system. We estimated a minimum companion mass of 0.0065 solar masses, assuming a neutron star mass of 1.4 solar masses, and an inclination angle of <75 degrees (suggested by the absence of eclipses or dips in its light-curve). The broad-band energy spectrum of the…

Search for multiwavelength emission from the binary millisecond pulsar PSR J1836-2354A in the globular cluster M22

2019

We present a multi-band search for X-ray, optical and $\gamma$-ray emission of the radio binary millisecond pulsar J1836-2354A, hosted in the globular cluster M22. X-ray emission is significantly detected in two Chandra observations, performed in 2005 and 2014, at a luminosity of $\sim$2-3$\times$10$^{30}$ erg s$^{-1}$, in the 0.5-8 keV energy range. The radio and the X-ray source positions are found consistent within 1$\sigma$ error box. No detection is found in archival XMM-Newton and Swift/XRT observations, compatible with the Chandra flux level. The low statistics prevents us to assess if the X-ray source varied between the two observations. The X-ray spectrum is consistent with a power…

An XMM-Newton and INTEGRAL view on the hard state of EXO 1745-248 during its 2015 outburst

2017

CONTEXT - Transient low-mass X-ray binaries (LMXBs) often show outbursts lasting typically a few-weeks and characterized by a high X-ray luminosity ($L_{x} \approx 10^{36}-10^{38}$ erg/sec), while for most of the time they are found in X-ray quiescence ($L_X\approx10^{31} -10^{33}$ erg/sec). EXO 1745-248 is one of them. AIMS - The broad-band coverage, and the sensitivity of instrument on board of {\xmm} and {\igr}, offers the opportunity to characterize the hard X-ray spectrum during {\exo} outburst. METHODS - In this paper we report on quasi-simultaneous {\xmm} and {\igr} observations of the X-ray transient {\exo} located in the globular cluster Terzan 5, performed ten days after the begin…

Is Complexity of Daily Activity Associated with Physical Function and Life Space Mobility among Older Adults?

2022

Purpose Information about mobility, and physical function may be encoded in the complexity of daily activity pattern. Therefore, daily activity pattern complexity metrics could provide novel insight regarding the relationship between daily activity behaviour and health. The purpose of the present study was to examine the association between the complexity of daily activity behaviour, and mobility and physical function among community-dwelling older adults aged 75, 80, and 85 years-of-age. Methods A total of 309 participants wore accelerometers concurrently on the thigh and the trunk for at least 3 consecutive days. Five activity states (lying, sitting, standing, walking, or activity other t…