Search results for "c12"

Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF …

2015

Down-regulation of transcription factors AP-1, Sp-1, and NF-kappa B precedes myocyte differentiation.

1996

Terminal differentiation of myocytes involves withdrawal from the cell cycle, induction of myogenin expression, and finally formation of myotubes. To study the factors that regulate the initial phase of muscle differentiation, we analyzed the binding activities of transcription factors AP-1, Sp-1, and NF-kappa B in L6, C2C12, and rhabdomyosarcoma BA-Han-1C cells. Temporal changes in transcription factor binding activities were compared to the activation of myogenin promoter-driven CAT reporter gene and the expression level of myogenin, a master gene of myogenic differentiation. We observed a prominent decrease in the nuclear binding activities of AP-1, Sp-1, and NF-kappa B already 12 to 24 …

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

2000

The basic symptoms of Alzheimer's dementia, i.e., a loss in cognitive function, are due to impaired nicotinic cholinergic neurotransmission. To compensate for this impairment by drug treatment, blockers of the acetylcholine-degrading enzyme acetylcholinesterase are applied, even though this approach obviously is prone to many side-effects, including those of muscarinic nature. We have recently described a novel class of nicotinic acetylcholine receptor ligands which, similar to the action of benzodiazepines on GABA(A) receptors, allosterically potentiate submaximal nicotinic responses. The sensitizing effect is a consequence of facilitated channel opening in the presence of allosterically p…

Effects of eight weeks of physical training on physical performance and heart rate variability in children

2017

Kraama, Liisa. 2013. Effects of eight weeks physical training on physical performance and heart rate variability in children. University of Jyvaskyla, Department of Biology of Physical Activity. Master’s Thesis in Exercise Physiology. 52 pp. Physical activity and aerobic capacity have decreased among children and adolescents during the last decades. Physically active adults have been shown to have higher heart rate variability (HRV) than less active adults. In adults training-induced changes in physical performance have been shown to be related to increase in HRV, especially in high frequency component (HF), which is a marker of parasympathetic activity. The purpose of this study was to exa…

Goal-setting strategy and psychological differences in marathon runners compared by gender

2019

Prior to a marathon race, we conducted a cross sectional study with 122 male and 18 female recreational runners at the Expo. Demographic information, running experience, competition level, training details, goal and finishing times, and PODIUM questionnaire on psychological state variables were collected. Motivation, training volume, experience, and relative performance were comparable between male and female marathon runners. However, men were more ambitious and perceived higher self-confidence and fitness, although overestimated their goals ( M dif = -10.4, SD = 16.7] minutes, p < .001). Women perceived higher social support, reported higher anxiety levels, were more accurate in their est…

Constructive Optimization of Vulcanization Installations in Order to Improve the Performance of Conveyor Belts

2019

Conveyor belts of special importance must have superior mechanical characteristics. The joining by vulcanization of the conveyor belts allows to obtain superior performances, but it has been found that at the vulcanizing joint of the conveyor belts, there is a &ldquo

Constitutive Models for the Tensile Behaviour of TRM Materials: Literature Review and Experimental Verification

2021

In recent years, the scientific community has focused its interest on innovative inorganic matrix composite materials, namely TRM (Textile Reinforced Mortar). This class of materials satisfies the need of retrofitting existing masonry buildings, by keeping the compatibility with the substrate. Different recent studies were addressed to improve the knowledge on their mechanical behaviour and some theoretical models were proposed for predicting the tensile response of TRM strips. However, this task is complex due to the heterogeneity of the constituent materials and the stress transfer mechanism developed between matrix and fabric through the interface in the cracked stage. This paper present…

Men's doubles professional tennis on hard courts: Game structure and point ending characteristics

2019

Despite the great tradition and importance of the doubles game in professional tennis, no literature has analysed to date the performance of professional players. Therefore, the information on the characteristics of the game, or the tactics related to how the points are won in doubles play is scarce. The objective of this study has been to describe the basic characteristics of the structure of the doubles game, and to establish how the points finish in doubles professional tennis played on hard courts. Thirty-four ATP doubles matches played in 2018 were analysed, which included a total of 40 professional players. As per the game structure, the results showed that, in comparison to the singl…

Modeling of Melt Flow and Heat Transfer in Stationary Gas Tungsten Arc Welding with Vertical and Tilted Torches

2021

A 3D numerical simulation was conducted to study the transient development of temperature distribution in stationary gas tungsten arc welding with filler wire. Heat transfer to the filler wire and the workpiece was investigated with vertical (90°) and titled (70°) torches. Heat flux, current flux, and gas drag force were calculated from the steady-state simulation of the arc. The temperature in the filler wire was determined at three different time intervals: 0.12 s, 0.24 s, and 0.36 s. The filler wire was assumed not to deform during this short time, and was therefore simulated as solid. The temperature in the workpiece was calculated at the same intervals using heat flux, current flux, ga…

Onset of Convection in an Inclined Anisotropic Porous Layer with Internal Heat Generation

2019

The onset of convection in an inclined porous layer which is heated internally by a uniform distribution of heat sources is considered. We investigate the combined effects of inclination, anisotropy and internal heat generation on the linear instability of the basic parallel flow. When the Rayleigh number is sufficiently large, instability occurs and a convective motion is set up. It turns out that the preferred motion at convection onset depends quite strongly on the anisotropy ratio, &xi