Search results for "cacophony"

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Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca2+ pump PMCA

2021

Significance Synaptic vesicle (SV) release from presynaptic terminals requires nanometer precise control of action potential (AP)–triggered calcium influx through voltage-gated calcium channels (VGCCs). SV recycling also depends on calcium signals, though in different spatiotemporal domains. Mechanisms for separate control of SV release and recycling by AP-triggered calcium influx remain elusive. Here, we demonstrate largely independent regulation of release and recycling by two different populations of VGCCs (Cav2, Cav1), identify Cav1 as one of potentially multiple calcium entry routes for endocytosis regulation, and show functional separation of simultaneous calcium signals in the nanome…

Drosophila ; Dmca1D ; cacophony ; PMCA ; synapse0301 basic medicine570ATPasecacophonyPresynaptic TerminalsAction PotentialsEndocytosisDmca1DSynaptic vesicleExocytosis03 medical and health scienceschemistry.chemical_compoundGlutamatergicPlasma Membrane Calcium-Transporting ATPases0302 clinical medicinePMCAsynapsemedicineAnimalsDrosophila ProteinsAxonNeurotransmitterProbabilityMotor NeuronsMultidisciplinaryVoltage-dependent calcium channelbiologyCell Membrane424500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; BiologieBiological SciencesEndocytosisCell biologyElectrophysiology030104 developmental biologymedicine.anatomical_structureDrosophila melanogasterchemistryReceptors Glutamatebiology.proteinDrosophilaCalciumCalcium ChannelsSynaptic Vesicles030217 neurology & neurosurgeryNeuroscienceProceedings of the National Academy of Sciences of the United States of America
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