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showing 10 items of 2320 documents
Electromagnetically induced transparency in Doppler-broadened three-level systems with resonant standing-wave drive
2000
We study electromagnetically induced transparency for a probe travelling-wave (TW) laser field in closed Doppler-broadened three-level systems driven by a resonant standing-wave (SW) laser field of moderate intensity (its Rabi frequencies are smaller than the Doppler width of the driven transition). We show that probe windows of transparency occur only for values of the probe-to-drive field frequency ratio R close to half-integer values. For optical transitions and typical values of Doppler broadening for atoms in a vapor cell, we show that for R > 1 a SW drive field is appreciably more efficient than a TW driving in inducing probe transparency. As an example, we consider parameters for a r…
Millimeter-wave and microwave signal generation by low-bandwidth electro-optic phase modulation
2009
We propose, analyze and numerically illustrate a photonic-based technique for waveform generation of electrical signals approaching the 50 GHz bandwidth with time apertures as large as a few nanoseconds, by low-frequency, up to 2 GHz, electro-optic phase modulation of time-stretched optical pulses. Synthesis of the electrical waveform relies on phase-to-amplitude conversion of the modulated signal by a group delay dispersion circuit designed to behave as a transversal filter with N taps. Although arbitrary waveform generation capabilities are limited, a wide variety of user-defined signals are numerically demonstrated by appropriately designing the low-frequency signal driving the electro-o…
Slowdown and speedup of light pulses using the self-compensating photorefractive response
2011
We study theoretically the effects of pulse slowdown and speedup in ferroelectric Sn2P2S6 possessing a self-compensating photorefractive response. It is shown that both these effects can be implemented in one sample for sufficiently large values of the coupling strength. In contrast to other types of the photorefractive response (local and nonlocal), the output pulses do not suffer from strong spatial amplification and broadening.
Electromagnetically induced transparency with standing-wave drive in the frequency up-conversion regime
2003
We study Electromagnetically Induced Transparency in Doppler-broadened three-level media for probe to drive field frequency ratio R<1 and moderate drive intensities. We show that in this regime a standing-wave drive is more efficient than a travelling-wave one, specially when R is close to half integer values.
Optical gratings induced by field-free alignment of molecules
2006
We analyze the alignment of molecules generated by a pair of crossed ultra-short pump pulses of different polarizations by a technique based on the induced time-dependent gratings. Parallel polarizations yield an intensity grating, while perpendicular polarizations induce a polarization grating. We show that both configurations can be interpreted at moderate intensity as an alignment induced by a single polarized pump pulse. The advantage of the perpendicular polarizations is to give a signal of alignment that is free from the plasma contribution. Experiments on femtosecond transient gratings with aligned molecules were performed in CO2 at room temperature in a static cell and at 30 K in a …
Atomic Coherence Effects in Doppler-Broadened Three-Level Systems with Standing-Wave Drive
2001
We study atomic coherence effects (e.g., electromagnetically induced transparency, EIT, and amplification without inversion, AWI) for a probe travelling-wave (TW) laser field in closed Doppler-broadened three-level systems driven by a standingwave (SW) laser field of moderate intensity (its Rabi frequencies are smaller than the Doppler width of the driven transition). We show that probe windows of transparency occur only for values of the probe to drive field frequency ratio R close to half integer values. For optical transitions and typical values of Doppler broadening for atoms in a vapor cell, we show that for R > 1 a SW drive field is appreciably more efficient than a TW drive in induci…
Free-space delay lines and resonances with ultraslow pulsed Bessel beams
2008
We investigate the ultraslow motion of polychromatic Bessel beams in unbounded, nondispersive media. Control over the group velocity is exercised by means of the angular dispersion of pulsed Bessel beams of invariant transverse spatial frequency, which spontaneously emerge from near-field generators. Temporal dynamics in transients and resonances over homogeneous delay lines (dielectric slabs) are also examined.
Gauss-Type Quadrature Formulae for Parabolic Splines with Equidistant Knots
2010
We construct Gauss, Lobatto, and Radau quadrature formulae associated with the spaces of parabolic splines with equidistant knots. These quadrature formulae are known to be asymptotically optimal in Sobolev spaces W p 3. Sharp estimates for the error constant in W ∞ 3 are given.
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for for…
2013
This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the e…