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showing 10 items of 2320 documents

Neutralizing antibodies against rotavirus produced in transgenically labelled purple tomatoes

2011

Edible fruits are inexpensive biofactories for human health-promoting molecules that can be ingested as crude extracts or partially purified formulations. We show here the production of a model human antibody for passive protection against the enteric pathogen rotavirus in transgenically labelled tomato fruits. Transgenic tomato plants expressing a recombinant human immunoglobulin A (hIgA_2A1) selected against the VP8* peptide of rotavirus SA11 strain were obtained. The amount of hIgA_2A1 protein reached 3.6 ± 0.8% of the total soluble protein in the fruit of the transformed plants. Minimally processed fruit-derived products suitable for oral intake showed anti-VP8* binding activity and str…

biologyfungifood and beveragesPlant ScienceAgrobacterium tumefaciensbiology.organism_classificationmedicine.disease_causeFusion proteinIn vitroVirusMicrobiologylaw.inventionAntirrhinum majusBiochemistrylawRotavirusRecombinant DNAmedicineGenetically modified tomatoAgronomy and Crop ScienceBiotechnologyPlant Biotechnology Journal
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Neuropsychological underpinnings of the dynamics of bipolar disorder

2015

Although we have gained enormous insights into neurobiological and psychological underpinnings of bipolar disorder (BD) symptoms, our knowledge concerning pathogenic mechanisms initiating recurrent affective episodes is still fragmentary. Previous research has highlighted the role of significant life events and social rhythm in recurrent episodes of mania and depression. However, most studies share the drawback of retrospective self-report data, which are prone to recall biases and limited introspective abilities. Therefore, more objective data, such as neuropsychological and neurobiological measures are needed to further unravel the pathogenic mechanisms of the dynamics of bipolar disorder…

bipolar disorderBiological markersRecallEpidemiologyPublic Health Environmental and Occupational HealthNeuropsychologyBiological markers; bipolar disorder; brain imaging techniques; prospective studyCognitionEpidemiology for Behavioural Neurosciencesmedicine.diseaseDevelopmental psychologybrain imaging techniquesPsychiatry and Mental healthNeuroimagingMultiple timemedicineBipolar disordermedicine.symptomPsychologyManiaDepression (differential diagnoses)Clinical psychologyprospective study
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Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre.

2020

INTRODUCTION: Pancreatic cancer (PC), even in the absence of metastatic disease, has a dismal prognosis. One-third of them are borderline resectable (BRPC) or locally advanced unresectable PC (LAUPC) at diagnosis. There are limited prospective data supporting the best approach on these tumours. Neoadjuvant chemotherapy (ChT) is being increasingly used in this setting. METHODS: This is a retrospective series of consecutive patients staged as BRPC or LAUPC after discussion in the multidisciplinary board (MDB) at an academic centre. All received neoadjuvant ChT, followed by chemoradiation (ChRT) in some cases, and those achieving enough downstaging had a curative-intent surgery. Descriptive da…

borderline resectableCancer Researchmedicine.medical_specialtyFOLFIRINOXmedicine.medical_treatmentpancreatic cancerNeutropeniaAdenocarcinomalcsh:RC254-282Pancreatic cancerAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansProspective Studies1506Neoadjuvant therapyRetrospective StudiesOriginal ResearchChemotherapybusiness.industrymedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogenslocally advanced unresectableNeoadjuvant TherapyOxaliplatinSurgeryIrinotecanPancreatic NeoplasmsFOLFIRINOXOncologyFluorouracilbusinessmedicine.drugESMO open
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A concept for personal wellness management based on activity monitoring

2008

Lifestyle related health problems are increasing rapidly. Many of them could be prevented or alleviated by sufficient physical activity, enough sleep, and a balanced diet. Individual citizens have the main responsibility for their own health and wellness management in their daily lives. Motivational tools based on modern technologies can support people in this task. Vivago Personal Wellness Manager (PWM) is a concept for personal wellness management, based on continuous activity monitoring with a wrist-worn device combined with immediate feedback on daily activity, e.g., sleep and physical activity. The concept allows long-term monitoring of activity patterns and includes PC software for de…

business.industryApplied psychologyPhysical activityMean absolute errorHealthenhancing physical activityTask (project management)Activity monitoringHealth problemsEnergy expenditureWellness managementActivity monitoringHealth careEnergy expenditure estimationSleep (system call)businessPsychologySimulation
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Using Attribute Grammars for Description of Inductive Inference Search Space

1998

The problem of practically feasible inductive inference of functions or other objects that can be described by means of an attribute grammar is studied in this paper. In our approach based on attribute grammars various kinds of knowledge about the object to be found can be encoded, ranging from usual input/output examples to assumptions about unknown object's syntactic structure to some dynamic object's properties. We present theoretical results as well as describe the architecture of a practical inductive synthesis system based on theoretical findings.

business.industryComputer scienceAttribute grammarInferenceContext-free grammarInductive reasoningcomputer.software_genreObject (computer science)TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESRule-based machine translationTerminal and nonterminal symbolsFormal languageSyntactic structureArtificial intelligenceL-attributed grammarbusinesscomputerNatural language processing
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Facial animation by reverse morphing on a sequence of real images: application to film and video production

2000

Research on facial animation is as vast as the many interests and needs that can be found in the general public, television or film production. For Mac Guff Ligne, a company specialized in the fabrication of special effects and computer generated images, the needs and the constraints on such a topic are very big. Morphing is often used in facial animation, and consists in mixing several expression models. As we will discover, the advantages in using morphing are numerous, but the animation workload remains long and time-consuming. Our goal is to propose a fast and reliable animation tool that is based on the same morphing technique with which the graphic artists are familiar. Our method is …

business.industryComputer scienceFacial motion captureComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONAnimationMotion captureGeneralLiterature_MISCELLANEOUSComputer graphics (images)Interactive skeleton-driven simulationSkeletal animationComputer visionArtificial intelligenceElectrical and Electronic EngineeringPhysically based animationbusinessComputer facial animationComputer animationComputingMethodologies_COMPUTERGRAPHICSAnnales Des Télécommunications
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Invalid Syntax: NooJ Assisted Automatic Detection of Errors in Auxiliaries and Past Participles in Italian

2017

The work targets two areas of Italian morphosyntax: auxiliary selection (AS) and past participle agreement (PPA). In selecting such inflectional morphemes, learners of Italian commit frequent errors, even after a long period of constant study. We aim to enclose AS and PPA within the boundaries of NLP in order that a tool can be developed with a twofold purpose: first, it helps experts to build specific computer drills regarding AS and PPA; second, it assists self-taught learners in verifying whether their periphrastic sentences in Italian are well-turned. This area of Computer-Assisted Language Learning is currently poorly investigated. Further research might substantiate the importance of …

business.industryComputer sciencemedia_common.quotation_subjectComputer Science (all)Foreign languageCommitInflectional morpheme generationLanguage acquisitioncomputer.software_genreSyntaxAgreementSettore L-LIN/01 - Glottologia E LinguisticaMorphemeCALLSelection (linguistics)Mathematics (all)Artificial intelligencebusinessParticiplecomputerAutomatic identification of grammatical relationNatural language processingmedia_common
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Some applications of a theorem of Shirshov to language theory

1983

Some applications of a theorem of Shirshov to language theory are given: characterization of regular languages, characterization of bounded languages, and a sufficient condition for a language to be Parikh-bounded.

business.industryGeneral EngineeringComputer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing)Characterization (mathematics)computer.software_genrePhilosophy of languageAlgebraTheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESRegular languageBounded functionComputer Science::Programming LanguagesArtificial intelligencebusinesscomputerNatural language processingEngineering(all)MathematicsInformation and Control
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Primary Analysis of Phase 2 Results for Cemiplimab in Patients (pts) with Locally Advanced Basal Cell Carcinoma (laBCC) who Progress on or are Intole…

2021

Abstract not available.

business.industryLocally advancedmedicineCancer researchBasal cell carcinomaIn patientmedicine.diseasebusinessHedgehogSKIN The Journal of Cutaneous Medicine
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Sport and Quality of Life

2022

Negli ultimi trent’anni lo sport ha assunto un significato molto rilevante nella vita delle persone e, seppure con notevoli differenze, sia nei paesi a sviluppo economico avanzato, sia in quelli in via di sviluppo. A livello individuale, esso ha costituito un’area di investimento identitario quando ha assunto la forma di sport spettacolo del quale fruire, alimentando la pratica del tifo e il fandom o costituendo il modello di uno stile di vita vincente; ma anche quando ha assunto la forma di pratica del tempo libero attraverso la quale tenersi in forma, facendo crescere, in questo caso, la diffusione di una cultura della salute e del benessere. Si tratta di due modalità di approcciare al co…

but also when he took the form of free time practice through which to keep fit making grow in this case the diffusion of a culture of health and well-being. These are two ways of approaching the consumption of sports by spectators and actorIn the last thirty years sport has taken on a very significant meaning in people's lives and albeit with considerable differences both in advanced economic development countries and in developing countries. On an individual level it constituted an area of identity investment when it assumed the shape of “sport spectacle” to be enjoyed fueling the practice of cheering and fandom or constituting the model of a winning lifestyleand the two ways of use can be strongly related to the perception and assessment of the quality of life. The “semantic universes” which however connote sport and “free time sports” have often appeared polarized. Commercial sport and sports professionalism are intertwined with the institutions of economics politics and culture which above all stress its “spectacularity” in order to capture first and foremost the audience. But also the sport of leisure time is intertwined with the actions of the institutions of economics politics and culture with the difference that these stress above all its “healthy value” aimed at the “healthy and rational” investment of time in an activity which improves the quality of life in the short medium and long period. This polarization between the consumption of sport entertainment - commercial sport - and the consumption of sport as a leisure activity - sport for all - has become increasingly interconnected precisely because of the increased collective identity demand via sport. In other words we have witnessed the spread of shape of sports entertainment that recall the importance of sports for psychophysical well-being for integration and social participation for the reduction of social inequalities ethnic and cultural differences and in which the importance assumed was weakened in the show from agonism from competition from the physical confrontation between two contenders or two teams. A sport in which we act with competitors as well as against competitors. And on the other hand we have gradually witnessed the spectacularization of sports in our free time to the point that the sharing of the results obtained through the declination of a competitive spirit that presents itself as directed no longer against other contenders but against its own performance limits it has become the way in which each person makes part of his or her own life spectacular the one he often considers most authentic. The aim of this work is to describe how the intertwining between the commercial/professional dimension of the sports show and the playful/recreational dimension of sports practice are fueled by a demand and an offer of social identity that characterizes these two “semantic universes”.Settore SPS/07 - Sociologia Generale
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