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showing 10 items of 2320 documents

Management of oral Graft versus Host Disease with topical agents: a systematic review

2015

Background: Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD. Material and Methods: We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine’s Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: “oral”, “graft”, “versus”, “host”…

medicine.medical_specialtyAdministration TopicalGraft vs Host DiseaseOdontologíaReviewDisease03 medical and health sciences0302 clinical medicinemedicineHumansIntensive care medicineGlucocorticoidsGeneral Dentistrybusiness.industryMucosal lesions030206 dentistryMedically compromised patients in Dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludSurgeryTransplantationGraft-versus-host diseaseOtorhinolaryngologyTopical agents030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASSurgeryStem cellMouth DiseasesbusinessComplicationImmunosuppressive Agents
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Effectiveness of tDCS at Improving Recognition and Reducing False Memories in Older Adults

2021

Background: False memories tend to increase in healthy and pathological aging, and their reduction could be useful in improving cognitive functioning. The objective of this study was to use an active–placebo method to verify whether the application of transcranial direct current stimulation (tDCS) improved true recognition and reduced false memories in healthy older people. Method: Participants were 29 healthy older adults (65–78 years old) that were assigned to either an active or a placebo group

medicine.medical_specialtyAgingHealth Toxicology and Mutagenesismedicine.medical_treatmentlcsh:Medicinetrue recognitionAudiologyTranscranial Direct Current StimulationPlacebo group050105 experimental psychologyArticle03 medical and health sciences0302 clinical medicineMemorymedicineGroup interactionHumans0501 psychology and cognitive sciencesCognitive skillAgedAged 80 and overTranscranial direct-current stimulationMemory errorsRecallexperimentbusiness.industry05 social scienceslcsh:RPublic Health Environmental and Occupational HealthRecognition Psychologyfalse recognitionFalse recognitionMental RecallbusinessOlder people030217 neurology & neurosurgeryInternational Journal of Environmental Research and Public Health
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Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema

2010

BACKGROUND Hereditary angioedema is characterized by recurrent attacks of angioedema of the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. Icatibant is a selective bradykinin B2 receptor antagonist. METHODS In two double-blind, randomized, multicenter trials, we evaluated the effect of icatibant in patients with hereditary angioedema presenting with cutaneous or abdominal attacks. In the For Angioedema Subcutaneous Treatment (FAST) 1 trial, patients received either icatibant or placebo; in FAST-2, patients received either icatibant or oral tranexamic acid, at a dose of 3 g daily for 2 days. Icatibant was given once, subcutaneously, at a dose of 30 mg. …

medicine.medical_specialtyAngioedemabusiness.industryGeneral MedicinePlacebomedicine.diseaseSurgerylaw.inventionEcallantidechemistry.chemical_compoundRandomized controlled trialchemistrylawIcatibantAnesthesiaHereditary angioedemamedicinemedicine.symptomBradykinin receptorbusinessTranexamic acidmedicine.drugNew England Journal of Medicine
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Long-term care of AIDS and non-communicable diseases.

2011

medicine.medical_specialtyAnti-HIV AgentsDeveloping countryMedically Underserved AreaUterine Cervical NeoplasmsZambiaComorbidityHealth servicesAcquired immunodeficiency syndrome (AIDS)Cause of DeathMedicineHumansMass ScreeningIntensive care medicineDeveloping CountriesAcquired Immunodeficiency SyndromeHealth Services Needs and Demandbusiness.industryCancerGeneral Medicinemedicine.diseaseLong-term careFamily medicineChronic DiseaseFeasibility StudiesFemalebusinessLancet (London, England)
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Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits

2003

Objective— The effects of combined expression of human hepatic lipase (HL) and human apolipoprotein B (apoB) on low-density lipoprotein (LDL) subclasses were examined in rabbits, a species naturally deficient in HL activity. Methods and Results— In apoB-transgenic rabbit plasma, >80% of the protein was found in the 1.006- to 1.050-g/mL fraction. Gradient gel electrophoresis (GGE) of this fraction revealed two distinct species, designated large and small LDL. A denser fraction (d=1.050 to 1.063 g/mL) contained small LDL as well as another discrete LDL subspecies, designated very small LDL. Expression of HL resulted in reductions in protein concentrations in the 1.006- to 1.050-g/mL densi…

medicine.medical_specialtyApolipoprotein BRecombinant Fusion ProteinsTriacylglycerol lipaseAnimals Genetically ModifiedSpecies SpecificityInternal medicineCentrifugation Density GradientmedicineAnimalsHumansTriglyceridesApolipoproteins BGel electrophoresischemistry.chemical_classificationLagomorphabiologyLipasebiology.organism_classificationAnimal FeedSpecific Pathogen-Free OrganismsLipoproteins LDLMolecular WeightEndocrinologyEnzymechemistrybiology.proteinElectrophoresis Polyacrylamide GelFemalelipids (amino acids peptides and proteins)Density gradient ultracentrifugationRabbitsHepatic lipaseCardiology and Cardiovascular MedicineLipoprotein
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Dose-finding study of oxaliplatin associated to capecitabinebased preoperative chemoradiotherapy in locally advanced rectal cancer

2018

// Gemma Bruera 1, 2 , Mario Di Staso 3 , Pierluigi Bonfili 3 , Antonio Galvano 4 , Rosa Manetta 5 , Gino Coletti 6 , Roberto Vicentini 7 , Stefano Guadagni 2, 8 , Corrado Ficorella 2, 9 , Ernesto Di Cesare 2, 3 , Antonio Russo 4 and Enrico Ricevuto 1, 2 1 Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy 2 Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy 3 Radiotherapy, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L’Aquila, L’Aquila, Italy 4 Medical Oncology, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo,…

medicine.medical_specialtyCapecitabine; Chemoradiotherapy; Dose-finding; Locally advanced rectal cancer; Oxaliplatin; OncologyColorectal cancerSettore MED/06 - Oncologia Medicamedicine.medical_treatmentRectumchemoradiotherapyCapecitabine03 medical and health sciences0302 clinical medicinelocally advanced rectal cancermedicineMucositisbusiness.industryGeneral surgerycapecitabineoxaliplatinmedicine.diseaseOxaliplatinRadiation therapyRegimenmedicine.anatomical_structureOncology030220 oncology & carcinogenesisdose-findingClinical Research Paperbusiness030217 neurology & neurosurgeryChemoradiotherapymedicine.drug
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Infraclavicular access to the axillary vein-new possibilities for the catheterization of the central veins in the intensive care unit

2016

Central vein cannulation is one of the most commonly performed procedures in intensive care. Traditionally, the jugular and subclavian vein are recommended as the first choice option. Nevertheless, these attempts are not always obtainable for critically ill patients. For this reason, the axillary vein seems to be a rational alternative approach. In this narrative review, we evaluate the usefulness of the infraclavicular access to the axillary vein. The existing evidence suggests that infraclavicular approach to the axillary vein is a reliable method of central vein catheterization, especially when performed with ultrasound guidance.

medicine.medical_specialtyCatheterization Central VenousShoulderCritical Care030232 urology & nephrologyCritical Care and Intensive Care Medicinelaw.invention03 medical and health sciences0302 clinical medicinelawIntensive caremedicineHumansAxillary VeinVeinUltrasonography Interventionalinfraclavicular access; ultrasound; intensive carebusiness.industryCritically ill030208 emergency & critical care medicineGeneral MedicineIntensive care unitVein catheterizationSurgerycentral veinIntensive Care UnitsAnesthesiology and Pain Medicinemedicine.anatomical_structurecannulation; axillary veincardiovascular systemCentral veinsAnatomic LandmarksAxillary veinbusinessSubclavian veinAnaesthesiology Intensive Therapy
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Why Do We Have to Use Chemotherapy?

2018

The use of chemotherapy (CT) in localized rectal cancer (LARC) has two aims: first, to improve the local effect of radiotherapy by giving concomitant chemoradiation and second, to decrease systemic relapses by early treatment for occult micrometastatic disease or to shrink bulky local tumours. Neoadjuvant treatment is reserved for locally advanced disease, as defined by pelvic magnetic resonance imaging, a very useful and accurate tool to identify high-risk features for local or systemic relapse [1]. We are going to address why we have to use CT in LARC.

medicine.medical_specialtyChemotherapymedicine.diagnostic_testbusiness.industryColorectal cancermedicine.medical_treatmentMagnetic resonance imagingmedicine.diseaseOccultRadiation therapyNeoadjuvant treatmentLocally advanced diseaseConcomitantMedicineRadiologybusiness
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Critically ill patients with cirrhosis and low serum sodium.

2010

medicine.medical_specialtyCirrhosisCritically illbusiness.industrySodiumcirrhosisGastroenterologyMEDLINEchemistry.chemical_elementSodium bloodmedicine.diseasechemistryCritical illnessmedicineProspective cohort studyIntensive care medicinebusiness
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Relationship between the oral cavity and cardiovascular diseases and metabolic syndrome

2013

The components of the human body are closely interdependent; as a result, disease conditions in some organs or components can influence the development of disease in other body locations. The effect of oral health upon health in general has been investigated for decades by many epidemiological studies. In this context, there appears to be a clear relationship between deficient oral hygiene and different systemic disorders such as cardiovascular disease and metabolic syndrome. The precise relationship between them is the subject of ongoing research, and a variety of theories have been proposed, though most of them postulate the mediation of an inflammatory response. This association between …

medicine.medical_specialtyContext (language use)ReviewDiseaseOral hygieneDiabetes ComplicationsDiabetes mellitusInternal medicineEpidemiologymedicineHumansObesityPeriodontitisIntensive care medicineGeneral DentistryMetabolic SyndromePeriodontitisbusiness.industryMedically compromised patients in Dentistrymedicine.diseaseObesityEndocrinologyOtorhinolaryngologyCardiovascular DiseasesSurgeryMetabolic syndromeMouth DiseasesbusinessMedicina Oral Patología Oral y Cirugia Bucal
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