Search results for "cam"
showing 10 items of 4055 documents
P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus
2011
Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …
Precambrian crustal evolution and continental drift
1981
One of the major questions of Precambrian research is whether present-day plate tectonic models can be applied to the evolution of the ancient continental crust or whether the tectonic style suggests a unidirectional and therefore non-uniformitarian development in response to gradual changes in the global thermal regime through time.
Analysing the Financial Soundness of the Commercial Banks in Romania: An Approach based on the Camels Framework
2013
Abstract The Romanian banking system has undergone through tremendous changes in the last decade, its financial soundness and performance being paramount in the achievement of a stable and sustainable economic growth. Thus, the aim of our research is to comparatively analyse the financial soundness of the commercial banks that operate in Romania. In order to achieve this we have used one of the most popular methods for the analysis of the financial soundness of banks, namely the CAMELS framework. The obtained results highlight the strengths and the vulnerabilities of the analysed banks, underlining the need to strengthen the concerns of the decision makers from banks to improve and increase…
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain
2009
Recently, we could demonstrate in rats that a short transient oligemic period of only 20-minute duration, induced by systemic hypotension, resulted in a transient decline of spatial memory capacities without any histological damage over a subsequent period of 6 months. In our present study, we checked for more subtle alterations within the highly vulnerable hippocampal CA1 subfield using quantification of neuronal cell density and semi-quantitative analysis of the ischemia-sensitive protein MAP2. Since hippocampal excitatory and inhibitory neurotransmitter receptors are crucially involved in spatial memory processes, quantitative in vitro receptor autoradiography was performed using [(3)H]M…
Stimulatory and inhibitory effects of ethanol on hippocampal acetylcholine release
1998
Using the microdialysis technique and sensitive HPLC procedures for the determination of acetylcholine (ACh) and ethanol, we investigated the release of ACh in rat hippocampus after acute ethanol administration. Systemic administration of ethanol (0.8 and 2.4 g/kg i.p.) led to peak ethanol concentrations of 21 and 42 mM in the hippocampus, respectively. The high dose caused a long-lasting inhibition of basal ACh release by up to 33%. Local infusion of scopolamine (1 microM) enhanced hippocampal ACh release up to eightfold in the presence of neostigmine (10 microM), and this stimulated release was also inhibited after systemic ethanol administration (by up to 45%). The low dose of ethanol (0…
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety,…
2011
Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is expressed in the CNS, where its function is unknown. Here, we show, for the first time, the relevance of MIF expression for adult hippocampal neurogenesis. We identify MIF expression in neurogenic cells (in stem cells, cells undergoing proliferation, and in newly proliferated cells undergoing maturation) in the subgranular zone of the rodent dentate gyrus. A causal function for MIF in cell proliferation was shown using genetic (M…
Smart cameras on a chip: using complementary metal-oxide-semiconductor (CMOS) image sensors to create smart vision chips
2020
Abstract: In this chapter, we introduce the fundamental concept of smart cameras on a chip or smart vision chips that simultaneously integrate the same die image capture capability and highly complex image processing. Successive technology scaling has made possible the integration of specific processing elements designed at chip level, at column level or at pixel level. To illustrate this continuous evolution, we survey three different categories of vision chips, exploring first the pioneering works on artificial retinas, then describing the most significant computational chips, and finally presenting the most recent image processing chips able to perform complex algorithms at a high frame …
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells
2018
CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymp…
A study of international work camp volunteers' attitudes and experiences of English as a lingua franca
2014
Yhä useammalla nuorella aikuisella on omakohtaisia kokemuksia englannin kielen käytöstä monikulttuurisessa ympäristössä, esimerkiksi vaihto-opiskelun tai vapaaehtoistyön kautta. Kyseisissä tilanteissa puhuttu englanti poikkeaa monin tavoin oppitunneilla opituista ja natiivien käyttämästä englannista. Tutkielman aiheena on selvittää, kuinka Suomessa vuonna 2012 järjestetyille vapaaehtoistyöleireille osallistuneet nuoret kokivat englannin kielen käytön leireillä ja millaisia asenteita heillä on englannin kieltä kohtaan. Tavoitteena on selvittää, kuinka he asennoituvat omaan ja toistensa kielenkäyttöön, aksenttiin, natiivien kanssa viestintään, mukauttamiseen ja koodinvaihtoon ja millaisia kei…
Verkkohuijausten tyypit sosiaalisessa mediassa
2017
Types of online scams in social media. In this thesis, types of online scams in social media are examined first by defining online scams and then applying the principles of them to social media setting. The thesis is a literature review in which it was found that in social media there are similar types of scams than outside of it. These types of scams were phishing scams, scams related to social engineering malware attacks and 419 -scams. There were a couple of scam scenarios that were not detected outside of social media context due to social networking site required as a platform for the scams. These were scams involving impersonation of celebrities or friends, services offering followers…