Search results for "camp"
showing 10 items of 1995 documents
P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus
2011
Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain
2009
Recently, we could demonstrate in rats that a short transient oligemic period of only 20-minute duration, induced by systemic hypotension, resulted in a transient decline of spatial memory capacities without any histological damage over a subsequent period of 6 months. In our present study, we checked for more subtle alterations within the highly vulnerable hippocampal CA1 subfield using quantification of neuronal cell density and semi-quantitative analysis of the ischemia-sensitive protein MAP2. Since hippocampal excitatory and inhibitory neurotransmitter receptors are crucially involved in spatial memory processes, quantitative in vitro receptor autoradiography was performed using [(3)H]M…
Stimulatory and inhibitory effects of ethanol on hippocampal acetylcholine release
1998
Using the microdialysis technique and sensitive HPLC procedures for the determination of acetylcholine (ACh) and ethanol, we investigated the release of ACh in rat hippocampus after acute ethanol administration. Systemic administration of ethanol (0.8 and 2.4 g/kg i.p.) led to peak ethanol concentrations of 21 and 42 mM in the hippocampus, respectively. The high dose caused a long-lasting inhibition of basal ACh release by up to 33%. Local infusion of scopolamine (1 microM) enhanced hippocampal ACh release up to eightfold in the presence of neostigmine (10 microM), and this stimulated release was also inhibited after systemic ethanol administration (by up to 45%). The low dose of ethanol (0…
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety,…
2011
Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is expressed in the CNS, where its function is unknown. Here, we show, for the first time, the relevance of MIF expression for adult hippocampal neurogenesis. We identify MIF expression in neurogenic cells (in stem cells, cells undergoing proliferation, and in newly proliferated cells undergoing maturation) in the subgranular zone of the rodent dentate gyrus. A causal function for MIF in cell proliferation was shown using genetic (M…
A study of international work camp volunteers' attitudes and experiences of English as a lingua franca
2014
Yhä useammalla nuorella aikuisella on omakohtaisia kokemuksia englannin kielen käytöstä monikulttuurisessa ympäristössä, esimerkiksi vaihto-opiskelun tai vapaaehtoistyön kautta. Kyseisissä tilanteissa puhuttu englanti poikkeaa monin tavoin oppitunneilla opituista ja natiivien käyttämästä englannista. Tutkielman aiheena on selvittää, kuinka Suomessa vuonna 2012 järjestetyille vapaaehtoistyöleireille osallistuneet nuoret kokivat englannin kielen käytön leireillä ja millaisia asenteita heillä on englannin kieltä kohtaan. Tavoitteena on selvittää, kuinka he asennoituvat omaan ja toistensa kielenkäyttöön, aksenttiin, natiivien kanssa viestintään, mukauttamiseen ja koodinvaihtoon ja millaisia kei…
Fabrication of graphene ruthenium-complex heterostructures
2015
The aim of this study is to understand the photoresponse of a Ruthenium-complex/graphene heterostructure. Early work demonstrated that light detection by graphene field effect devices was enhanced by dropcasting Ruthenium Complex molecules. Here we proposed to fabricate a new class of devices where the Ruthenium-complex molecules are embedded between two layer of CVD monolayer graphene.
La Edad de Plata dedicada: mapas del paratexto y de las redes culturales en la obra poética de las escritoras españolas (1901–1936)
2019
La presente Tesis doctoral se propone analizar las redes de colaboración, apoyo y afecto que llevaron a cabo las poetas españolas de la Edad de Plata (1901-1936) que publicaron sus libros durante este periodo en lengua castellana, para el impulso de su personalidad autoral y la profesionalización de su escritura. Asimismo, pretendemos recuperar la memoria de estas autoras a través de la búsqueda de material histórico inédito y de sus archivos personales, en el caso de que se encuentren preservados. Para reconstruir estas relaciones entre poetas, así como con otros agentes culturales, partiremos de los elementos paratextuales que rodean al texto literario: prólogos, epílogos, dedicatorias o …
Le passage d'un siècle à l'autre (1914-1929) : traumatismes et nouvelles donnes politiques
2005
Participación ciudadana en los perfiles de Facebook de los partidos españoles. Análisis de comentarios en la campaña electoral de 2015
2017
El uso de redes sociales por parte de los partidos políticos para la difusión de sus mensajes posibilita la participación ciudadana y la creación de debate entre los usuarios. El presente estudio analiza esta participación a través de los comentarios que escriben los ciudadanos en las páginas de Facebook de los principales partidos políticos españoles durante la campaña de las elecciones generales de 2015. El objetivo es establecer las características de la participación ciudadana en un contexto político y comprobar si existen diferencias entre los comentarios publicados en los distintos partidos. El estudio utiliza una metodología cuantitativa articulada en dos fases. En primer lugar, se a…
Harmonic generation in all-dielectric metasurfaces
2023
Nonlinear light generation is a key phenomenon in many optical systems. Recently, the field of nonlinear optics has moved to the miniaturization of conventional bulky components. Among all the new platforms that have been proposed, dielectric nanoscale resonators represent excellent candidates for light generation and manipulation. When arranged in periodic arrays, such high refractive index scattering components become an artificial material called metasurface. Several approaches for designing platforms with enhanced optical nonlinearities at moderate pump intensities have been proposed. In this chapter, we review the most recent results on second- and third-order nonlinear processes in hi…