Search results for "camp"
showing 10 items of 1995 documents
Role for Chromatin Remodeling Factor Chd1 in Learning and Memory
2019
Precise temporal and spatial regulation of gene expression in the brain is a prerequisite for cognitive processes such as learning and memory. Epigenetic mechanisms that modulate the chromatin structure have emerged as important regulators in this context. While posttranslational modification of histones or the modification of DNA bases have been examined in detail in many studies, the role of ATP-dependent chromatin remodeling factors (ChRFs) in learning- and memory-associated gene regulation has largely remained obscure. Here we present data that implicate the highly conserved chromatin assembly and remodeling factor Chd1 in memory formation and the control of immediate early gene (IEG) r…
Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated
2017
Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…
Representações sociais, sens pratique, poder simbólico e o processo de construção do ser docente
2019
A partir de las elaboraciones teóricas de los fundadores del campo de investigación de las representaciones sociales, se pretende avanzar en la construcción de un diálogo entre esta teoría y la praxis social de Pierre Bourdieu, centrándose en la relación entre las representaciones sociales, la praxis sensorial (como manifestación del hábito) y el poder simbólico, dimensión ausente en el modelo moscoviciano. La base empírica a partir de la cual se desarrollan las reflexiones presentes en este artículo se apoya en investigaciones realizadas sobre el proceso de construcción del ser docente, en la realidad de algunas ciudades del nordeste brasileño. En este sentido, se destaca lo que se cree qu…
Effetto della dimensione dell'anello sulla conducibilità idraulica del suolo saturo misurata con la tecnica SFH
2009
Nel lavoro è stata esaminata la relazione tra la conducibilità idraulica del suolo saturo, Kfs, misurata in campo con la tecnica Simplified Falling Head (SFH) e la dimensione della superficie campionata con una singola prova. L’indagine è stata condotta in un suolo franco-sabbioso ed in uno franco-limoso, esplorando la medesima superficie complessiva (0.71 m2) con anelli di diametro compreso tra 0.15 e 0.30 m. Nel suolo franco-sabbioso, le misure di Kfs effettuate con gli anelli piccoli sono risultate significativamente più elevate di quelle ricavate con gli anelli grandi. In particolare, i valori medi hanno mostrato una discrepanza di un fattore 1.7 e il ricorso agli anelli piccoli ha dete…
Financement et moralisation de la vie politique
2018
International audience
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
2008
The Werner syndrome helicase/3′-exonuclease (WRN) is a major component of the DNA repair and replication machinery. To analyze whether WRN is involved in the repair of topoisomerase-induced DNA damage we utilized U2-OS cells, in which WRN is stably down-regulated (wrn-kd), and the corresponding wild-type cells (wrn-wt). We show that cells not expressing WRN are hypersensitive to the toxic effect of the topoisomerase I inhibitor topotecan, but not to the topoisomerase II inhibitor etoposide. This was shown by mass survival assays, colony formation and induction of apoptosis. Upon topotecan treatment WRN deficient cells showed enhanced DNA replication inhibition and S-phase arrest, whereas af…
Identificazione del campione ottimale di consumi per la stima del bilancio idrico in un ATO: il caso di Siracusa
2011
Tecniche analitiche avanzate applicate al controllo qualità e tracciabilità in campo alimentare.
2011
Synthesis, crystal structure and Hirshfeld analysis of a crystalline compound comprising a 1/1 mixture of 1-[(1R,4S)- and 1-[(1S,4R)-1,7,7-trimethyl-…
2020
A racemic mixture of (R)- and (S)-camphor thiosemicarbazone, which crystallizes in the centrosymmetric space group C2/c, is reported.
El campo mediático-digital y la diferenciación social
2021
La digitalización de la sociedad ha abierto nuevos horizontes de investigación a la disciplina sociológica. Sin embargo, los análisis realizados en los últimos años tienden a dejar en un lugar secundario las referencias clásicas de la sociología. Este trabajo pretende mostrar la viabilidad del análisis de la cultura digital desde la perspectiva de los campos sociales de Pierre Bourdieu. Las herramientas teóricas y metodológicas que proporciona el autor francés pueden ser muy útiles para evitar tanto el utopismo digital como los análisis críticos influidos por perspectivas neomarxistas, centrados mayoritariamente en las formas de explotación económica. La teoría de los campos sociales puede …