Search results for "cancers"

showing 10 items of 276 documents

Socio-demographic, health-related, and individual correlates of diagnostic self-testing by lay people: Results from a representative survey in Germany

2017

Introduction A broad range of self-tests (testing for e.g. HIV, cancer, hepatitis B/C) have become available and can be conducted by lay consumers without the help of a health professional. The aims of this study were to (a) investigate the prevalence of self-testing, (b) identify the most frequently used self-tests, and (c) explore the associations between socio-demographic, health-related and individual factors with self-testing. Methods A face-to-face plus paper-pencil cross-sectional survey was conducted. The sample consisted of 2.527 respondents who were representative of the German population in terms of the age, sex, and residence. Basic descriptive statistics and univariate logistic…

Malelcsh:MedicinePathology and Laboratory MedicineLogistic regressionGeographical locationsEndocrinology0302 clinical medicineSurveys and QuestionnairesGermanyDiagnosisMedicine and Health Sciences030212 general & internal medicineComputer Networkslcsh:ScienceFatigueMultidisciplinary030503 health policy & servicesAttendanceEuropeLaypersonOncologyFemaleAnatomy0305 other medical sciencePsychologyResearch ArticleAdultComputer and Information SciencesEndocrine Disorders03 medical and health sciencesSigns and SymptomsDiagnostic MedicineMental Health and PsychiatryCancer Detection and DiagnosisDiabetes MellitusHumansEuropean UnionDemographyColorectal CancerInternetDescriptive statisticslcsh:RUnivariateCancers and NeoplasmsBiology and Life SciencesLife satisfactionKidneysRenal SystemSelf CareSocial ClassMetabolic Disorderslcsh:QResidencePeople and placesRural areaDemographyPLOS ONE
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Survival of patients with hepatocellular carcinoma (HCC) treated by percutaneous radio-frequency ablation (RFA) is affected by complete radiological …

2013

Background: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC) early stage hepatocellular carcinoma (HCC) as curative treatments. Aim: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis. Methods: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treated with RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. A single lesion was observed in 113/151 (74.8%), two lesions in 32/151 (21.2%), and three lesions in 6/151 (4%) of patients. Results: The overall survival rates …

Malemedicine.medical_specialtyCirrhosisPercutaneousCarcinoma HepatocellularClinical Research Designmedicine.medical_treatmentCancer Treatmentlcsh:MedicineCatheter ablationGastroenterology and HepatologyGastroenterologyCohort StudiesInternal medicineGastrointestinal CancersGastrointestinal TumorsmedicineHumansStage (cooking)lcsh:ScienceAgedMultidisciplinaryRadiotherapybusiness.industryLiver Diseaseslcsh:RLiver NeoplasmsCancers and NeoplasmsHepatocellular CarcinomaMiddle Agedmedicine.diseaseAblationFibrosisdigestive system diseasessurgical procedures operativeTreatment OutcomeCirrhosisOncologyRadiological weaponHepatocellular carcinomaCatheter AblationMedicineHepatocellular carcinoma survival RFAlcsh:QFemalebusinessLiver cancerResearch ArticlePloS one
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Trends of mortality due to oral and oropharyngeal cancers in Uruguay from 1997 to 2014

2020

Background To analyze the trends of oral and oropharyngeal cancer mortality in Uruguay between 1997 and 2014 according to sex and age groups and its possible association with sociodemographic factors. Material and Methods A time-series ecological study using secondary data was performed. The data about mortality due to oral and oropharyngeal cancers were obtained from the Statistics Vitals Department of the Public Health Ministry of Uruguay. To estimate the mortality trends of the historical series, by sex, anatomical site and age groups, linear regressions generated by the Prais-Winsten procedure were used. Results The analysis of mortality trends for oral cavity and oropharyngeal cancers …

Malemedicine.medical_specialtyNEOPLASIAS DE LA BOCAMORTALIDAD03 medical and health sciences0302 clinical medicineHumansMedicineNEOPLASIAS OROFARINGEASMortalityGeneral DentistryMouth neoplasmOropharyngeal cancerESTUDIOS DE SERIES TEMPORALESOral Medicine and Pathologybusiness.industryOral cancerResearchIncidenceIncidence (epidemiology)Public healthMortality rateEcological studyCancer030206 dentistryFACTORES DE TIEMPOmedicine.disease:CIENCIAS MÉDICAS [UNESCO]DISTRIBUCION POR EDAD Y SEXOOropharyngeal NeoplasmsOropharyngeal NeoplasmOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASUruguayTongue cancer.FemaleMouth NeoplasmsSurgeryPublic HealthbusinessOropharyngeal CancersDemography
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The impact of re-transurethral resection on clinical outcomes in a large multicentre cohort of patients with T1 high-grade/Grade 3 bladder cancer tre…

2015

Objectives To determine if a re-transurethral resection (TUR), in the presence or absence of muscle at the first TUR in patients with T1-high grade (HG)/Grade 3 (G3) bladder cancer, makes a difference in recurrence, progression, cancer specific (CSS) and overall survival (OS). Patients and methods In a large retrospective multicentre cohort of 2451 patients with T1-HG/G3 initially treated with bacille Calmette–Gu erin, 935 (38%) had a re-TUR. According to the presence or absence of muscle in the specimen of the primary TUR, patients were divided in four groups: group 1 (no muscle, no re-TUR), group 2 (no muscle, re-TUR), group 3 (muscle, no re-TUR) and group 4 (muscle, re-TUR). Clinical out…

Malemedicine.medical_treatment030232 urology & nephrologySettore MED/24 - Urologia0302 clinical medicineImmunologicRetrospective Studiehigh gradere-TURHazard ratioMiddle Agedmedicine.anatomical_structureAdministration IntravesicalTreatment Outcome030220 oncology & carcinogenesisUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]CohortUrinary Bladder NeoplasmBCG VaccineUrologic Surgical Proceduresbladder cancerFemaleHumanReoperationmedicine.medical_specialtyrecurrenceUrologyUrologyT1G3CystectomyArticleCystectomy03 medical and health sciencesbladder cancer; high grade; progression; re-TUR; recurrence; T1G3; UrologyAdjuvants ImmunologicUrethramedicineHumansAdjuvantsT1G3; bladder cancer; high grade; progression; re-TUR; recurrenceRetrospective StudiesAgedNeoplasm StagingBladder cancerbusiness.industryCancerRetrospective cohort studymedicine.diseaseSurgerybladder cancer; high grade; progression; re-TUR; recurrence; T1G3; Adjuvants Immunologic; Aged; BCG Vaccine; Cystectomy; Female; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Reoperation; Retrospective Studies; Treatment Outcome; Urethra; Urinary Bladder Neoplasms; UrologyUrethraUrinary Bladder NeoplasmsprogressionNeoplasm GradingbusinessBCG vaccine
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Predicting trajectories of recovery in prostate cancer patients undergone Robot-Assisted Radical Prostatectomy (RARP)

2019

ObjectiveTo identify trends of patients' urinary and sexual dysfunctions from a clinical and psychological perspective and understand whether sociodemographic and medical predictors could differentiate among patients following different one-year longitudinal trajectories.MethodsAn Italian sample of 478 prostate cancer patients undergone Robot-Assisted Radical Prostatectomy completed the EPIC-26 survey between July 2015 and July 2016 at the pre-hospitalization (T0), 45 days (T1) and 3 (T2), 6 (T3), 9 (T4), and 12 months (T5) after surgery. Sociodemographic and clinical characteristics (age, BMI, diabetes, nerve-sparing procedure) were also collected. Latent Class Growth Analysis was conducte…

Malemedicine.medical_treatmentCancer Treatment030232 urology & nephrologyUrinary incontinenceProstate cancerPostoperative ComplicationsEndocrinology0302 clinical medicineErectile DysfunctionRobotic Surgical ProceduresQuality of lifeMedicine and Health SciencesrecoveyReproductive System ProceduresMultidisciplinaryProstatectomyProstate CancerQProstate DiseasesRRadical ProstatectomyTreatment OutcomeItalyOncology030220 oncology & carcinogenesisMedicinemedicine.symptomResearch Articlemedicine.medical_specialtySexual DysfunctionEndocrine DisordersUrologyScienceUrinary systemSurgical and Invasive Medical ProceduresAffect (psychology)03 medical and health sciencesDiabetes MellitusmedicineHumansProstatectomyIncontinenceSurgical ExcisionGeriatric Urologybusiness.industryCancers and Neoplasmsmedicine.diseaseGenitourinary Tract TumorsUrinary IncontinenceSexual dysfunctionSocioeconomic FactorsGeriatricsMetabolic DisordersQuality of LifePhysical therapybusinessSexual functionPLOS ONE
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The efficacy of BCG TICE and BCG Connaught in a cohort of 2,099 patients with T1G3 non–muscle-invasive bladder cancer

2016

BACKGROUND Potential differences in efficacy of different bacillus Calmette-Guerin (BCG) strains are of importance for daily practice, especially in the era of BCG shortage. OBJECTIVE To retrospectively compare the outcome with BCG Connaught and BCG TICE in a large study cohort of pT1 high-grade non-muscle-invasive bladder cancer patients. DESIGN, SETTING, AND PARTICIPANTS Individual patient data were collected for 2,451 patients with primary T1G3 tumors from 23 centers who were treated with BCG for the first time between 1990 and 2011. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS Using Cox multivariable regression and adjusting for the most important prognostic factors in this nonrandomiz…

Malemedicine.medical_treatmentIntravesical drug administration030232 urology & nephrologyKaplan-Meier EstimateBCG ConnaughtSettore MED/24 - Urologia0302 clinical medicineMaintenance therapyMedicine610 Medicine & healthhigh gradeAged 80 and overHazard ratioMiddle AgedAdministration IntravesicalTreatment OutcomeOncology030220 oncology & carcinogenesisCohortbladder cancerFemaleImmunotherapyNon muscle invasivemedicine.medical_specialtyrecurrenceUrologyBCG Connaught; BCG Tice; BCG vaccine; bladder cancer; high grade; Immunotherapy; Intravesical drug administration; progression; recurrence; T1G3; Oncology; UrologyT1G3ArticleMaintenance ChemotherapyBCG Connaught03 medical and health sciencesAdjuvants ImmunologicInternal medicineUrological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]HumansNeoplasm InvasivenessBCG vaccineAgedNeoplasm StagingProportional Hazards ModelsRetrospective StudiesCarcinoma Transitional CellBladder cancerbusiness.industryImmunotherapy ActiveBCG TiceImmunotherapymedicine.diseaseSurgeryUrinary Bladder NeoplasmsDrug EvaluationprogressionNeoplasm GradingbusinessBCG vaccineFollow-Up StudiesBCG Connaught; BCG Tice; BCG vaccine; Immunotherapy; Intravesical drug administration; T1G3; bladder cancer; high grade; progression; recurrenceUrologic Oncology: Seminars and Original Investigations
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The impact of portal vein tumor thrombosis on survival in patients with hepatocellular carcinoma treated with different therapies: A cohort study.

2020

Background Portal vein tumor thrombosis (PVTT) is a frequent complication of hepatocellular carcinoma (HCC), which leads to classification as advanced stage disease (regardless of the degree of PVTT) according to the Barcelona Clinic Liver Cancer Classification. For such patients, systemic therapy is the standard of care. However, in clinical reality, many patients with PVTT undergo different treatments, such as resection, transarterial chemoembolization (TACE), selective internal radiation therapy (SIRT), or best supportive care (BSC). Here we examined whether patients benefited from such alternative therapies, according to the extent of PVTT. Methods This analysis included therapy-naïve …

Malemedicine.medical_treatmentvirusesCancer TreatmentCardiovascular MedicineVascular MedicineDiagnostic RadiologyCohort Studies0302 clinical medicineMedical ConditionsMedicine and Health SciencesMedicineVenous ThrombosisMultidisciplinaryPortal VeinLiver DiseasesRadiology and ImagingSelective internal radiation therapyLiver NeoplasmsQRHematologyMiddle AgedTumor ResectionThrombosisMagnetic Resonance ImagingTreatment OutcomeSurgical OncologyOncologyCardiovascular Diseases030220 oncology & carcinogenesisHepatocellular carcinomaMedicine030211 gastroenterology & hepatologyFemaleRadiologyAnatomyLiver cancermedicine.drugResearch ArticleHepatic ResectionSorafenibAdultClinical Oncologymedicine.medical_specialtyCarcinoma HepatocellularImaging TechniquesScienceCardiologyRadiation TherapySurgical and Invasive Medical ProceduresGastroenterology and HepatologyResearch and Analysis MethodsVeins03 medical and health sciencesDigestive System ProceduresDiagnostic MedicineGastrointestinal TumorsHumansChemoembolization TherapeuticPortal VeinsBlood CoagulationAgedRetrospective StudiesSurgical ResectionCoagulation Disordersbusiness.industryProportional hazards modelCarcinomaCancers and NeoplasmsBiology and Life SciencesThrombosisHepatocellular Carcinomamedicine.diseaseSurvival AnalysisRadiation therapyCardiovascular AnatomyBlood VesselsClinical MedicinebusinessComplicationPLoS ONE
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Body mass index and complications following major gastrointestinal surgery

2018

Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastroint…

MaleobesityMultivariate analysisGastrointestinal DiseasesIMPACTSettore MED/18 - CHIRURGIA GENERALEBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complications; Gastroenterologydigestive tractTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]0302 clinical medicineGastrointestinal tractRisk FactorsMedicineProspective StudiesProspective cohort studyBody mass indexBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complications; Aged; Europe; Female; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Obesity; Postoperative Complications; Prospective Studies; Risk Factors; Body Mass IndexGastrointestinal NeoplasmsOUTCOMESPostoperative complications; body mass index; body weight; digestive tract; gastrointestinal tract; obesityGastroenterologyMiddle AgedBody mass index; Body weight; Digestive tract; Gastrointestinal tract; Obesity; Postoperative complicationsEurope030220 oncology & carcinogenesisMeta-analysisUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]CohortFemale030211 gastroenterology & hepatologyCohort studymedicine.medical_specialtybody mass indexMalignancyNO03 medical and health sciencesPostoperative complicationsbody weightSDG 3 - Good Health and Well-beingHumansDigestive tractObesityAgedbusiness.industrypostoperative complications; obesity; digestive tract; gastrointestinal tract; body mass index; body weightMORTALITYBody weightmedicine.diseaseObesitySettore MED/18SurgeryPostoperative complicationPostoperative Complications Obesity Digestive Tract Gastrointestinal Tract Body Mass Index Body Weight.gastrointestinal tractbusinessBody mass indexColorectal Disease
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Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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A Systematic Review of the Use of Social Media for Dissemination of Clinical Practice Guidelines

2021

Item does not contain fulltext CONTEXT: Clinical practice guideline (CPG) uptake does not occur spontaneously and requires active implementation, especially for long-term implementation. Social media (SoMe) with its power of rapid and global information exchange among physicians, patients, organizations, and stakeholders in the medical field can open up unprecedented opportunities for CPG dissemination. OBJECTIVE: The aim of this review was to assess the current use of SoMe in CPG dissemination across different medical specialties. EVIDENCE ACQUISITION: A systematic review (SR) of the literature was conducted using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) …

Medical educationbusiness.industryUrologyHealth Personnel030232 urology & nephrologyMEDLINEContext (language use)GuidelineClinical Practice03 medical and health sciences0302 clinical medicineSystematic reviewResearch Design030220 oncology & carcinogenesisUrological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]MedicineHumansSocial mediaPatient summarybusinessSocial MediaEvidence synthesis
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