Search results for "cannabinoid"
showing 10 items of 323 documents
Acetaldehyde, motivation and stress: Behavioral evidence of an addictive ménage à trois
2017
Acetaldehyde contributes to alcohol’s psychoactive effects through its own rewarding properties. Recent studies shed light on the behavioral correlates of acetaldehyde administration and the possible interactions with key neurotransmitters for motivation, reward and stress-related response, such as dopamine and endocannabinoids. This mini review critically examines acetaldehyde psychoactive properties, focusing on behavioral investigations able to unveil acetaldehyde motivational effects and their pharmacological modulation in vivo. Similarly to alcohol, rats spontaneously drink acetaldehyde, whose presence is detected in the brain following chronic self-administration paradigm. Acetaldehyd…
TRPV1 channels in nitric oxide-mediated signalling: insight on excitatory transmission in rat CA1 pyramidal neurons
2022
Nitric oxide (NO) is a fascinating signalling molecule implicated in a plethora of biological functions, especially at the synaptic level. Exploring neurotransmission in the hippocampus could be instrumental in the individuation of putative targets for nitric-oxide mediated neuromodulation, especially in terms of the potential repercussions on fundamental processes i.e. synaptic plasticity and excitability-related phenomena. Among these targets, endovanilloid signalling constitutes an object of study since Transient Receptors Vanilloid type 1 (TRPV1) channels possess a NO-sensitive gate modulating its activation. Also, NO has been referred to as a mediator for numerous endocannabinoid effec…
The CB1Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis
2012
The generation and specification of pyramidal neuron subpopulations during development relies on a complex network of transcription factors. The CB1cannabinoid receptor is the major molecular target of endocannabinoids and marijuana active compounds. This receptor has been shown to influence neural progenitor proliferation and axonal growth, but its involvement in neuronal differentiation and the functional impact in the adulthood caused by altering its signaling during brain development are not known. Here we show that the CB1receptor, by preventing Satb2 (special AT-rich binding protein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter activity, and Ctip2-po…
Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat
2010
Different studies have been shown a clear anticonvulsant activity exerted by cannabinoids (CB) through the CB1 receptor activation. The purpose of this study was to evaluate, in an in vivo experimental model of temporal lobe epilepsy (maximal dentate gyrus activation - MDA) in the rat, the protective effect of (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone (WIN 55,212-2, CB agonist) alone or in combination with N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251, selective CB1 antagonist). Pre-treatment with AM251 (1 mg kg-1, 30 min interval) dramatically reduced the signif…
Rimonabant: una nueva perspectiva en el tratamiento de las conductas adictivas
2006
Se revisa la farmacología, eficacia clínica, farmacocinética, seguridad y lugar en la terapéutica de rimonabant, un nuevo antagonista selectivo de los receptores cannabinoides CB1.Se realizó una revisión de la literatura primaria obtenida en el MEDLINE (1996 a septiembre del 2005), introduciendo las palabras clave rimonabant, SR 141716, SR 141716A, therapeutic applications, CB1 receptor modeling, obesity, smoking cesattion, endocannabinoid system, y rimonabant pharmacokinetics.Los estudios realizados con el antagonista selectivo del receptor CB1, rimonabant, han demostrado su eficacia clínica sobre la deshabituación al tabaco y sobre la reducción de la ingesta de alimentos y del peso corpor…
Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and …
2021
AbstractBackgroundFirst episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is consequent to patients being more vulnerable to the effects of cannabis use or to their heavier pattern of use. We aimed to determine whether extent of use predicted psychotic-like and euphoric intoxication experiences in patients and controls and whether this differs between groups.MethodsWe analysed data on patients who had ever used cannabis (n = 655) and controls who had ever used cannabis (n = 654) across 15 sites from six countries in the EU-GEI study (2010–2015). We used multiple regres…
Sintētisko kanabinoīdu un katinonu identifikācijas iespējas
2016
Vēl aizvien nelegālajā apritē parādās jaunas psihoaktīvās vielas, kuru identificēšanas iespējas ir apgrūtinātas un maz pētītas. Jaunās psihoaktīvās vielas ir potenciāls sabiedrības veselības drauds. Populārākās ir sintētiskie kanabinoīdi un sintētiskie katinoni. To iedarbība uz cilvēka organismu ir maz pētīta un neparedzama. Lai pētītu to iedarbību uz cilvēka organismu, ir nepieciešamas efektīvas un visaptverošas pētniecības metodes. Darba ir apkopoti dati par Latvijā biežāk sastopamajām jaunajām psihoaktīvajām vielām, kā arī apkopoti un analizēti dati par šo vielu noteikšanas metodēm, kā pielietojamāko metodi nosakot jauno psihoaktīvo vielu noteikšanu, var uzskatīt GH-MS/MS metodi. Atslēgv…
Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids.
2020
Abstract A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography–mass spectrometry (GC–MS) determination. Five synthetic cannabinoids were employed as model compounds 5F-ADB, MMB-CHMICA, THJ-2201, CUMYL-4CN-BINACA and MDMB-CHMCZCA. The most adequate operative conditions for MEPS were evaluated giving quantitative recoveries, from 89 to 124%, in synthetic and field saliva samples spiked with 125 and 250 μg/L of the studied cannabinoids, with the exception of MDMB-CHMCZCA in field saliva samples that provided slightly lower recoverie…
STUDIO DEI MECCANISMI DI MORTE CELLULARI INDOTTI DAL CANNABINOIDE SINTETICO WIN IN CELLULE TUMORALI IN COLTURA
2014
Per lungo tempo, i cannabinoidi sono stati considerati come farmaci lenitivi ma non curativi della patologia cancerosa. Tuttavia, negli scorsi anni, è stata suggerita una potenziale applicazione dei cannabinoidi come droghe antitumorali, anche se il loro meccanismo d’azione non è ancora ben conosciuto. Gli obiettivi di questo studio sono stati: - la valutazione degli effetti del cannabinoide sintetico WIN55,212-2 (WIN) su differenti linee di cellule tumorali in coltura (cellule di carcinoma colorettale HT29 e cellule di osteosarcoma umano MG63) e – la valutazione dei meccanismi molecolari indotti dal trattamento con il cannabinoide. I risultati riportati indicano che in entrambe le linee ce…