Search results for "cannabis"
showing 10 items of 174 documents
Comprehending and improving cannabis specialized metabolism in the systems biology era
2020
Cannabis sativa is a source of food, fiber and specialized metabolites such as cannabinoids, with psychoactive and pharmacological effects. Due to its expanding and increasingly-accepted use in medicine, cannabis cultivation is acquiring more importance and less social stigma. Humans initiated different domestication episodes whose later spread gave rise to a plethora of landrace cultivars. At present, breeders cross germplasms from different gene pools depending on their specific use. The fiber (hemp) and drug (marijuana) types of C. sativa differ in their cannabinoid chemical composition phenotype (chemotype) and also in the accumulation of terpenoid compounds that constitute a strain’s p…
Effect of Vermicompost Extract and Vermicompost-Derived Humic Acids on Seed Germination and Seedling Growth of Hemp
2017
Abstract Hemp (Cannabis sativa L.) cultivars grown for industrial use have recently emerged as a sustainable alternative source of industrial fibre and bioenergy, and is a highly valuable food and animal feed resource. The aim of the present study was to evaluate the effect of vermicompost extract, vermicompost mineral nutrient composition, and vermicompost-derived humic and fulvic acids on seed germination and growth of hemp seedlings. In general, separate application of all vermicompost components stimulated seed germination and hypocotyl and radicle growth, as well as increased chlorophyll concentration in cotyledons. Effective concentration range and the degree of stimulation varied sig…
Mothering under the influence: How perinatal drugs of abuse alter the mother-infant interaction
2018
AbstractAlthough drug-abusing women try to moderate their drug and alcohol use during pregnancy, they often relapse at a time when childcare needs are high and maternal bonding is critical to an infant’s development. In the clinical setting, the search for the neural basis of drug-induced caregiving deficits is complex due to several intervening variables. Rather, the preclinical studies that control for drug dose and regimen, as well as for gestational and postpartum environment, allow a precise determination of the effects of drugs on maternal behaviour. Given the relevance of the issue, this review will gather reports on the phenotypic correlates of maternal behaviour in preclinical stud…
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.
2017
Dysregulated adipocyte physiology leads to imbalanced energy storage, obesity, and associated diseases, imposing a costly burden on current health care. Cannabinoid receptor type-1 (CB1) plays a crucial role in controlling energy metabolism through central and peripheral mechanisms. In this work, adipocyte-specific inducible deletion of the CB1 gene (Ati-CB1- KO) was sufficient to protect adult mice from diet-induced obesity and associated metabolic alterations and to reverse the phenotype in already obese mice. Compared with controls, Ati-CB1-KO mice showed decreased body weight, reduced total adiposity, improved insulin sensitivity, enhanced energy expenditure, and fat depot-specific cell…
Neurological aspects of medical use of cannabidiol
2017
Background: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activities and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases. Objective: The aim of the present review was to describe the state of art about the pre-clinical research, the potential use and, when existing, t…
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings
2021
The European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI); The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024) (...)
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
2018
AbstractLiability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM - IV diagnosed AD. Genome - wide data on 14,904 individuals with AD and 37,944 controls from 28 case / control and family - based studies were meta - analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome - wide significant effects of different ADH1B variants were identified in European (rs1229984; p = …
Legislative framework of cannabis within the European Union. Analysis of legal status of recreational cannabis for personal possession
2019
This study reflect current legal situation in the European Union regarding legislation of cannabis. Taking into account the increasing tendency of this topic, the analysis is based on the assumption that cannabis although usually perceived as a soft drug, is a transnational threat as every narcotic substance. Therefore, it is necessary to analyze and work on this matter to ensure that fundamental values of human life are not negatively affected by the growing trend of liberalization of cannabis. The focus is on the recreational cannabis for personal possession as this type of usage is referred in the statistical data of countries most often. This study is not dealing with the medical cannab…
El cannabis y la reducción de riesgos y daños
2005
El presente artículo recoge la última sesión de un taller para el consumo responsable de cannabis. Se trata de un taller de prevención indicada, dirigida a consumidores habi¬tuales de cannabis, orientado desde el modelo de reducción de riesgos y daños, y desarrollado en la Facultad de Psicología de la Universidad del País Vasco, entre los años 2001 y 2003.En el artículo el autor señala los posibles efectos negativos que se derivan del consumo de cannabis. Estableciendo una diferencia entre el consumo ocasional y sus posibles riesgos, y el consumo crónico y sus posibles riesgos.En la línea de reducir los posibles riesgos y daños, el autor señala estrategias o líneas de actuación preferentes …
Algunas prácticas en torno al uso terapéutico del cannabis en Catalunya
2005
En el texto tratamos de explorar algunas iniciativas que se están llevando a cabo en Cataluña para la 'normalización' del uso terapéutico del cannabis. En el año 2000, gra¬cias a la mobilización de las mujeres de Ágata, se iniciaron unas vías legales para el uso terapéutico del cannabis que, formalmente, cuajó en la introducción de un cannabinoi¬des sintético no muy eficaz en la práctica. No obstante, esta iniciativa promovió muchas más cosas que son las que se describen en el artículo: prácticas clínicas que recomien¬dan el uso del cannabis, propuestas de investigación y, finalmente, el desarrollo próximo de un plan piloto de la Administración sanitaria catalana, para la dispensación del c…