Search results for "capability"
showing 10 items of 107 documents
Telomere length and physical performance among older people-The Helsinki Birth Cohort Study.
2019
Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional and longitudinal data, we studied 582 women and 453 men from the Helsinki Birth Cohort Study at two time-points; a baseline examination in 2001-2004 at a mean age of 61 years and a follow-up examination approximately 10 years later in 2011-2013. Telomere length was measured both at baseline and at follow-up using real-time quantitative polymerase chain reaction. Physical performance was evaluated only at follow-up using the Senior Fitness Test (SFT), which assesses stre…
El concepto de dignidad en la teoria de las capacidades de Martha Nussbaum | The Concept of Human Dignity according to Martha Nussbaum?s capability a…
2019
Resumen: La doctrina filosófica y política de derechos humanos, afirma que todos los hombres son iguales en dignidad y derechos. Sin embargo, el concepto de dignidad sigue siendo objeto de importantes debates filosóficos y jurídicos, ya que, si algunos pensadores y juristas sostienen que se trata de un criterio ético fundamental, otros se muestran escépticos y lo consideran un término vacío de contenido e incluso inútil. La vaguedad del concepto y el alcance de su significado ocupa un lugar relevante en el ámbito de la filosofía del derecho, tratándose de una noción que merece ser revisada. El presente artículo pretende esclarecer cuál es el significado que Marta Nussbaum otorga al concepto…
Virtual reality exposure and imaginal exposure in the treatment of fear of flying: a pilot study
2013
Fear of flying (FF) is an impairing psychological disorder that is extremely common in developed countries. The most effective treatment for this particular type of phobia is exposure therapy. However, there are few studies comparing imaginal exposure (IE) and virtual reality (VR) exposure for the treatment of FF. The present study compared the effectiveness of these two approaches using two manualized interventions based on the exposure technique. Patients with FF ( N = 15) were randomly assigned to either VR ( n = 7) or IE therapy ( n = 8), consisting of a total of eight sessions: two assessment sessions (pre-treatment and after the real flight) and six exposure therapy sessions, which w…
Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia
2013
Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we tested separately the response of a Drosophila RNAi model of FRDA ( Llorens et al., 2007) to treatment with the iron chelator deferiprone (DFP) and the antioxidant idebenone (IDE), which are both in clinical trials. The FRDA flies have a shortened life span and impaired motor coord…
The pricing capability lifecycle of digital innovations
2021
The pricing capability provides a basis for firms’ competitive advantage. However, to date, the literature has not investigated how this capability forms, develops, and matures. In this study, we define the pricing capability as a dynamic capability consisting of three operational building blocks (tools and data, human and relational resources, and processes, routines, and mechanisms) as well as two dynamic capability building blocks (alertness and responsiveness, and value-based strategic thinking). Furthermore, we propose the pricing capability lifecycle of digital innovations that incorporates insights of the dynamic capabilities view (DCV). Based on a longitudinal multi-case study of fi…
Diritti dei bambini, diritti delle famiglie. Promuovere e formare le “capacità” genitoriali
2020
The paper focuses on the reasons for the link between children's rights and family rights, in order to highlight that parenting educational competences are challenging risk factor in contexts of poverty and always decisive factor for the actual promotion of the rights of children and adolescents. More precisely, firstly the passages of of the Convention in which the necessity of the family is argued as primary context of children's rights. Secondly, it will be problematized the very idea of children's rights in the light of the "capability approach". On this basis, it will be asked whether, from a pedagogical point of view, the family can, as a whole, be the holder of a right to education…
Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines
2007
[EN] Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared wi…
Les systèmes éducatifs engendrent-ils des inégalités de bien-être ? : une recherche comparative internationale
2018
This study investigates the association between post-secondary education and well-being in international comparative perspective, conceptualizing well-being as a capability-informed measure of flourishing. Based on a combined human capital–capability approach, post-secondary education, operationalized as highest post-secondary educational credential, is hypothesized to relate positively with well-being net of individual-level and country-level controls at both the micro and macro levels of analysis. Prominent critiques of these approaches, suggesting indirect effects through occupational sorting at the individual level and economic factors at the country level, are also explored.Beyond thes…
Understanding the use of mobile phones in the agricultural sector in rural Indonesia: using the capability approach as lens
2012
This study aims to investigate the use of mobile phones in the agricultural sector and its possible contributions to development of developing countries, with special reference to Indonesia. In our interpretive work, the capability approach is used as a lens, and the study is informed by data from interviews with various actors and field observations. The paper unearths the pattern of use of mobile phones among farmers in their professional network and shows that ownership and use of mobile phones varies, depending on the farmers' location in the network hierarchy. The study further unveils that the conversion factors play a significant role in order to realise achievement (functionings) fr…
Dual Capability EAM for Agility in Business Capability Building : A Systems Theoretical View
2021
Through two cases of IT-enabled business capability building in large enterprises, this paper elucidates how the systems theory approach can explain the enterprise architecture management (EAM) challenge to support business agility. The observation in both of these cases is that a legacy EAM approach does not adapt to a business development scenario involving agility. This leads to a study of the nature of the challenges in EAM when enabling strategic business moves involving new technologies, at the business unit level. For the type of projects as in these cases, we do not find a fitting paradigm in the EAM literature. Suggested solutions are IT bimodality, or Two Speed IT. However, its co…