Search results for "case-control"
showing 10 items of 1685 documents
Comparison of right ventricular longitudinal strain imaging, tricuspid annular plane systolic excursion, and cardiac biomarkers for early diagnosis o…
2012
Aims To determine the role of assessing right ventricular (RV) function, using standard echocardiography and Doppler myocardial imaging (DMI), in the early diagnosis of cardiac amyloidosis and in the prediction of mortality. Methods and results Patients with primary systemic (AL) amyloidosis seen at our institution from 1 February 2004 through 31 October 2005 (N = 249) were categorized by left ventricular thickness and E′ velocity and compared with 38 age- and sex-matched controls. Standard echocardiographic and DMI examination were used to measure echocardiographic parameters of RV function: systolic tissue velocity, strain rate, and strain were determined for basal and middle RV free wall…
Precocity of the acquisition of language and type II spinal muscular atrophy in 3–4-year-old children: a study of 12 cases
2005
We studied the development of language in 3-4-year-old children with type II spinal muscular atrophy (SMA) (10 boys and two girls), aged 36-47 months (mean age 39.83+/-4.68 months) and compared our findings to a control group of 26 healthy children (mean age 40.00+/-4.43 months, 22 boys and four girls). We carried out a lexicogrammatical analysis of the data and we observed significant differences in the "vocabulary", "nouns", "verbs", "words" and "adverbs" variables between the children with SMA and the controls. Three- to four-year-old children suffering from type II spinal muscular atrophy, an autosomal genetic disease causing severe physical handicap (motor, functional, respiratory), pr…
The combination of diffractive and refractive multifocal intraocular lenses to provide full visual function after cataract surgery.
2009
PURPOSE To investigate if implantation of a far dominant refractive multifocal intraocular lens (IOL) in one eye and a near dominant diffractive multifocal IOL in the fellow eye improves range of vision following cataract surgery. METHODS This was a prospective, nonrandomized, case-control study involving 20 patients (40 eyes) scheduled for cataract surgery. Inclusion criteria were bilateral cataracts, minimum age 50 years, availability for follow-up visits, and informed consent. All patients received a far dominant refractive multifocal IOL (ReZoom, Abbott Medical Optics) in their dominant eye and a near dominant diffractive multifocal IOL (Tecnis ZM900, AMO) in their nondominant eye. Preo…
Physical Function and Properties of Quadriceps Femoris Muscle in Men With Knee Osteoarthritis
2008
To examine the objective physical function of the lower extremities, to measure the properties of quadriceps femoris muscle (QFM), and to assess subjective disabilities in men with knee osteoarthritis (OA) and to compare the results with those obtained from age- and sex-matched control subjects.Cross-sectional study.Rehabilitation clinic in a university hospital.Male volunteers (n=54) (age range, 50-69y) with knee OA and randomly selected healthy, age- and sex-matched control subjects (n=53).Not applicable.Physical function evaluated with a test battery including the QFM composition measurement, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the RAND 36-Item…
Basal growth hormone concentrations in blood and the risk for prostate cancer: A case-control study
2005
OBJECTIVE To assess the relationship between basal serum growth hormone (GH) levels and prostate cancer risk. METHODS We conducted a population-based case-control study; cases included 68 men, aged 45–85 years, diagnosed with incident, primary, histologically confirmed, and clinically apparent (stage B and higher) prostate cancer. Controls included 240 men, frequency matched on age and residential area. Age, race, BMI, waist circumference, history of enlarged prostate, education, and current smoking status, were all considered as possible confounders. RESULTS We found a statistically significant trend of decreasing prostate cancer risk across increasing GH quintiles, in both crude (OR: 0.31…
Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?
2007
To assess whether circulating levels of carbohydrate antigen 125 (CA125) predict subsequent 6-month all-cause mortality in patients after the index hospitalisation for acute heart failure (HF).Prospective cohort study at a single teaching centre in Spain.529 consecutive patients with acute HF admitted in a single university centre were analysed. In addition to the traditional clinical information, CA125 (U/ml) was measured during the early course of hospitalisation. The independent association between baseline CA125 and mortality was assessed with Cox regression analysis. The follow-up was limited to 6 months.349 (66%) patients showed serum levels of CA12535 U/ml (established cut-off point …
Prediction Accuracy of a Novel Dynamic Structure-Function Model for Glaucoma Progression
2014
Purpose To assess the prediction accuracy of a novel dynamic structure-function (DSF) model to monitor glaucoma progression. Methods Longitudinal data of paired rim area (RA) and mean sensitivity (MS) from 220 eyes with ocular hypertension or primary open-angle glaucoma enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. Rim area and MS were expressed as percent of mean normal based on an independent dataset of 91 healthy eyes. The DSF model uses centroids as estimates of the current state of the disease and velocity vectors as estimates of direction and rate of change over time. The first three visits were used to pre…
Low bone mineral density is a significant risk factor for low-energy distal radius fractures in middle-aged and elderly men: A case-control study
2011
Abstract Background In general there is a lack of data on osteoporosis and fracture in men; this also includes low-energy distal radius fractures. The objectives of this study were to examine BMD and identify factors associated with distal radius fractures in male patients compared with controls recruited from the background population. Methods In a 2-year period, 44 men 50 years or older were diagnosed with low-energy distal radius fractures, all recruited from one hospital. The 31 men who attended for osteoporosis assessment were age-matched with 35 controls. Demographic and clinical data were collected and BMD at femoral neck, total hip and spine L2-4 was assessed by dual energy X-ray ab…
N-Terminal Fragment of Pro B-type Natriuretic Peptide as a Marker of Contrast-Induced Nephropathy After Primary Percutaneous Coronary Intervention fo…
2015
Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is frequent and associated with long-term renal impairment and mortality. Early markers of CIN are needed to improve risk stratification. We aimed to assess whether N-terminal fragment of pro B-type natriuretic peptide (Nt-proBNP) could be associated with CIN. From the French regional RICO survey, all the consecutive patients who underwent primary PCI for STEMI, from January 1, 2001, to December 3, 2013, were included. Nt-proBNP circulating levels were assessed on admission. CIN was defined as an increase in serum creatinine26.5 μmol/L or50% within 48 to 7…
CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins.
2007
Abstract Background CD14 receptor is a mediator of the inflammatory response to bacterial products. A functional polymorphism in the promoter of the CD14 gene (CD14 C-260T) was associated with coronary heart disease and atherosclerosis albeit with conflicting data. Methods To better clarify the role of CD14 in atherosclerosis, we typed CD14 C-260T polymorphism in old Italian (Central of Italy) atherosclerotic patients with carotid stenosis related to lipid assessment, inflammation (soluble CD14, IL-6 serum levels) and IL-6, TNF-α, IL-10, Metallothioneins (MT) gene expressions in carotid plaques. Results There was an increased frequency of TT homozygotes in patients when compared to controls…