Search results for "case-control"
showing 10 items of 1685 documents
Factors explaining being present at work in the forest industry, case–control study
2015
Objectives: The aim of the study was to examine factors explaining few sickness absence hours (=SAH) among forest industry employees. Methods: The source population consisted of 636 forest industry employees in Finland, of which 140 were used as cases (SAH ≤ 1.5% during the past 6.5 years). Controls (140) were randomly selected from the source population (SAH > 1.5%). The study data were collected via a questionnaire. The response rate was 65.4% (mean age 48.5 years, men 67%). Discriminant and log-linear analysis were used to examine the relationships between variables and study groups. Results: Workers are more likely to have few sickness absences when their overall subjective health condi…
Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa.
2013
Retinitis Pigmentosa is a common form of hereditary retinal degeneration constituting the largest Mendelian genetic cause of blindness in the developed world. It has been widely suggested that oxidative stress possibly contributes to its pathogenesis. We measured the levels of total antioxidant capacity, free nitrotyrosine, thiobarbituric acid reactive substances (TBARS) formation, extracellular superoxide dismutase (SOD3) activity, protein, metabolites of the nitric oxide/cyclic GMP pathway, heme oxygenase-I and inducible nitric oxide synthase expression in aqueous humor or/and peripheral blood from fifty-six patients with retinitis pigmentosa and sixty subjects without systemic or ocular …
Peripheral Frequency of CD4+ CD28- Cells in Acute Ischemic Stroke: Relationship With Stroke Subtype and Severity Markers.
2015
CD4+ CD28− T cells also called CD28 null cells have been reported as increased in the clinical setting of acute coronary syndrome. Only 2 studies previously analyzed peripheral frequency of CD28 null cells in subjects with acute ischemic stroke but, to our knowledge, peripheral frequency of CD28 null cells in each TOAST subtype of ischemic stroke has never been evaluated. We hypothesized that CD4+ cells and, in particular, the CD28 null cell subset could show a different degree of peripheral percentage in subjects with acute ischemic stroke in relation to clinical subtype and severity of ischemic stroke. The aim of our study was to analyze peripheral frequency of CD28 null cells in subjects…
Exposure to video display terminals and risk of small-for-gestational-age birth
2010
In this study, the authors analyzed the association between video display terminal (VDT) use before and during the three trimesters of pregnancy and risk of small-for-gestational-age (SGA) birth in a case-control study. The cases for this study were 555 women who delivered SGA births. The controls were 1966 women who gave birth at term to healthy infants of normal weight. In terms of the length of exposure, the odds ratios (OR) of SGA birth were 1.2 for less than one hour and 1.3 for between two and 20 hours per week. For higher usage (more than 20 hours per week), the OR was 1.2 (95% CI: [Confidence Interval] 0.9-1.7). The authors conclude that this study does not show any association betw…
Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case–control EpiGEICAM study
2014
BACKGROUND: Although there are solid findings regarding the detrimental effect of alcohol consumption, the existing evidence on the effect of other dietary factors on breast cancer (BC) risk is inconclusive. This study aimed to evaluate the association between dietary patterns and risk of BC in Spanish women, stratifying by menopausal status and tumour subtype, and to compare the results with those of Alternate Healthy Index (AHEI) and Alternate Mediterranean Diet Score (aMED). METHODS: We recruited 1017 incident BC cases and 1017 matched healthy controls of similar age (±5 years) without a history of BC. The association between 'a priori' and 'a posteriori' developed dietary patterns and B…
Household water source and the risk of childhood brain tumours: results of the SEARCH International Brain Tumor Study.
2004
Background The period in utero is a time of increased vulnerability. Offspring of pregnant women exposed to carcinogenic substances in drinking water may be more likely to develop cancer. We examined whether household water source and the presence of nitrates or nitrites in residential water were associated with increased risks of childhood brain tumours (CBT). Methods We used data from a multicentre, case-control study with maternal information on residential water source, and nitrate/nitrite levels of tap water measured by dipstick. Subjects included 836 CBT cases and 1485 controls from five countries. Results The risks of CBT associated with reliance on well water (versus public water) d…
Contribution of polymorphisms in genes associated with craniofacial development to the risk of nonsyndromic cleft lip and/or palate in the Brazilian …
2012
Background and Objective: Nonsyndromic cleft lip and/or palate (NSCL/P) is a complex disease associated with both genetic and environmental factors. One strategy for identifying of possible NSCL/P genetic causes is to evaluate polymorphic variants in genes involved in the craniofacial development. Design: We carried out a case-control analysis of 13 single nucleotide polymorphisms in 9 genes related to craniofacial development, including TBX1, PVRL1, MID1, RUNX2, TP63, TGFB3, MSX1, MYH9 and JAG2 , in 367 patients with NSCL/P and 413 unaffected controls from Brazil to determine their association with NSCL/P. Results: Four out of 13 polymorphisms (rs28649236 and rs4819522 of TBX1, rs7940667 o…
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
2013
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10…
Role of PTPRJ genotype in papillary thyroid carcinoma risk
2010
The strong genetic predisposition to papillary thyroid carcinoma (PTC) might be due to a combination of low-penetrance susceptibility variants. Thus, the research into gene variants involved in the increase of susceptibility to PTC is a relevant field of investigation. The gene coding for the receptor-type tyrosine phosphatase PTPRJ has been proposed as a cancer susceptibility gene, and its role as a tumor suppressor gene is well established in thyroid carcinogenesis. In this study, we want to ascertain the role of PTPRJ genotype in the risk for PTC. We performed a case–control study in which we determined the PTPRJ genotype for the non-synonymous Gln276Pro and Asp872Glu polymorphisms by PC…
Comparison of Studies on Mobile Phone Use and Risk of Tumors
2010
published results of ameta-analysis of studies on mobile phone use and risk of tumors. Intheir analysis, the authors included 23 case-control studies, covering abroad spectrum of tumor entities including uveal melanoma, testicu-lar cancer, parotid gland tumors, and brain tumors.However, the authors give no rationale for pooling these hetero-geneous, biologically rather diverse cancer sites, for which the local-ized exposure from the use of mobile phones is completely different.The key difference between this particular meta-analysis com-pared with earlier ones is the use of a quality score. The use of qualityscoreshasbeenreportedtobea“formofsubjectivitymasqueradingasobjectivity”andithasbeen…