Search results for "catastrophe"
showing 10 items of 58 documents
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
2009
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable challenge for fundamental and applied biomedical research, and has tremendous implications for the development of novel therapeutic strategies. It is, therefore, of utmost importance to standardize the experimental procedures that identify dying and dead cells in cell cultures and/or in tissues, from model organisms and/or humans, in healthy and/or pathological scenarios. Thus far, dozens of methods have been proposed to quantify cell death-related parameters. However, no guid…
Catastrophic risks and the pricing of catastrophe equity put options
2021
In this paper, after a review of the most common financial strategies and products that insurance companies use to hedge catastrophic risks, we study an option pricing model based on processes with jumps where the catastrophic event is captured by a compound Poisson process with negative jumps. Given the importance that catastrophe equity put options (CatEPuts) have in this context, we introduce a pricing approach that provides not only a theoretical contribution whose applicability remains confined to purely numerical examples and experiments, but which can be implemented starting from real data and applied to the evaluation of real CatEPuts. We propose a calibration framework based on his…
Pressure stability field of Mg-perovskite under deep mantle conditions: A topological approach based on Bader's analysis coupled with catastrophe the…
2019
Abstract The pressure stability field of the Mg-perovskite phase was investigated by characterizing the evolution of the electron arrangement in the crystal. Ab initio calculations of the perovskite structures in the range 0–185 GPa were performed at the HF/DFT (Hartree-Fock/Density Functional Theory) exchange–correlation terms level. The electron densities, calculated throughout the ab-initio wave functions, were analysed by means of the Bader's theory, coupled with Thom's catastrophe theory. To the best of our knowledge the approach is used for the first time. The topological results show the occurrence of two topological anomalies at P~20 GPa and P~110 GPa which delineate the pressure ra…
Les catastrophes naturelles au Moyen Âge (XIIe-XVe siècle)
2017
International audience; Catastrophe : le terme renvoie dans nos représentations contemporaines à des images de destruction, de désorganisation sociale et éventuellement de mort de masse. Les événements tels que les inondations, les tremblements de terre, les tempêtes, etc., sont inévitablement pensés sur le mode du drame et de la tragédie. Viennent à l'esprit la nécessité de comprendre l'événement à travers un bilan des pertes matérielles et surtout humaines, la détresse des populations sinistrées, le devoir gouvernemental et non-gouvernemental de développer l'aide humanitaire, et le nécessaire travail de mémoire d'un malheur collectif. C’est en considérant ce faisceau de réaction en tant q…
La catastrophe et l'humaniste: le tremblement de terre de 1504-1505 vu par Filippo Beroaldo dans son Opusculum de terraemotu
2007
International audience
Essai de réflexion sur la réaction aux inondations en milieu urbain au XVe siècle : du seuil de tolérance catastrophique des sociétés riveraines à la…
2010
International audience
Une catastrophe qui rampe : Dijon face aux insectes (c. 1450- c. 1550)
2005
International audience
L'évolution de la représentation des catastrophes en Méditerranée à travers la peinture : le passage du fatalisme au rationalisme
2007
International audience
MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019
Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…
On universality of critical behavior in the focusing nonlinear Schrödinger equation, elliptic umbilic catastrophe and the Tritronquée solution to the…
2008
We argue that the critical behavior near the point of “gradient catastrophe” of the solution to the Cauchy problem for the focusing nonlinear Schrodinger equation \(i\epsilon \varPsi _{t}+\frac{\epsilon^{2}}{2}\varPsi _{xx}+|\varPsi |^{2}\varPsi =0\) , e ≪1, with analytic initial data of the form \(\varPsi (x,0;\epsilon)=A(x)e^{\frac{i}{\epsilon}S(x)}\) is approximately described by a particular solution to the Painleve-I equation.