Search results for "cb"
showing 10 items of 647 documents
Anergy in self-directed B lymphocytes from a statistical mechanics perspective
2012
The ability of the adaptive immune system to discriminate between self and non-self mainly stems from the ontogenic clonal-deletion of lymphocytes expressing strong binding affinity with self-peptides. However, some self-directed lymphocytes may evade selection and still be harmless due to a mechanism called clonal anergy. As for B lymphocytes, two major explanations for anergy developed over three decades: according to "Varela theory", it stems from a proper orchestration of the whole B-repertoire, in such a way that self-reactive clones, due to intensive interactions and feed-back from other clones, display more inertia to mount a response. On the other hand, according to the `two-signal …
Transient frailty induced by cell division. Observation, reasons and implications
2021
We know that stress-factors, e.g. X-rays, have an effect on cells that is more lethal in rapid exponential growth than in stationary phase. It is this effect which makes radiotherapy effective in cancer treatment. This stress effect can be explained in two ways: (a) more vulnerability in the growth phase, (b) improved protection capacity and repair mechanisms in the stationary phase. Although the two explanations do not exclude each other, they are very different in the sense that (a) is a general mechanism whereas (b) is strain and stress-factor dependent. In this paper we explore major facets of (a). Firstly, we emphasize that (a) can account for known experimental stress-factor evidence.…
Is there an infant mortality in bacteria?
2021
This manuscript proposes a significant step in our long-run investigation of infant mortality across species. Since 2016 (Berrut et al. 2016) a succession of studies (Bois et al. 2019) have traced infant mortality from organisms of high complexity (e.g. mammals) down to unicellular organisms. Infant mortality may be considered as a filtering process through which organisms with potentially lethal congenital defects are eliminated. Such defects may have many causes but here we focus particularly on mishaps resulting from non-optimal conditions in the production of proteins, enzymes and other crucial macromolecules. The statistical signature of infant mortality consists in a falling age-speci…
Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice
2021
Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results in animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses in rats consuming a high fat diet (HFD). However, the mechanisms by which asperuloside exerts its anti-obesity properties were not clarified. Here, we investigated homeostatic and nutrient-sensing mechanisms regulating food intake in mice consuming HFD. We confirmed the anti-obesity properties of asperuloside and, importantly, we identified some mechanisms that could be responsible for its therapeutic effect. Asperuloside reduced body weight …
Contributed discussion on article by Pratola [Comment on "M.T. Pratola, Efficient metropolis-hastings proposal mechanisms for Bayesian regression tre…
2016
Contains fulltext : 161650.pdf (Publisher’s version ) (Open Access) The author should be commended for his outstanding contribution to the literature on Bayesian regression tree models. The author introduces three innovative sampling approaches which allow for efficient traversal of the model space. In this response, we add a fourth alternative. 3 p.
T cell-mediated cytotoxicity: discrimination between antigen recognition, lethal hit and cytolysis phase.
1974
Using a 51Cr release cytotoxicity assay, the cytotoxic effector phase of in vitro activated mouse T lymphocytes (killer cells) against 51Cr-labeled target cells has been investigated. It is shown that within 5–10 minutes of contact between killer cells and target cells, the target cells are already committed to lysis, therefore, antigen recognition and “lethal hit” must have taken place within this period of time. In contrast, target cell lysis (cytolysis phase) requires up to 3–4 h in order to be completed; it occurs independently of killer cells and it is highly temperature dependent. The killer cell-dependent phase (antigen-recognition and “lethal hit”) is dissociated into two consecutiv…
Featuring Gregory M. Nixon’s Work with Commentaries & Responses. HOLLOWS OF MEMORY. From Individual Consciousness to Panexperientialism and Beyond
2010
Table of Contents Article Preface/Introduction Gregory M. Nixon 213-215 From Panexperientialism to Conscious Experience: The Continuum of Experience Gregory M. Nixon 216-233 Hollows of Experience Gregory M. Nixon 234-288 Myth and Mind: The Origin of Human Consciousness in the Discovery of the Sacred Gregory M. Nixon 289-337 ………………………………………………………………………………………………….. Commentary Brief Comment on Gregory Nixon’s Hollows of Experience: Derrida Frederick D. Abraham 338-341 Playing With Your Food: Review of “Hollows of Experience” by Greg Nixon William A. Adams 342-345 Brief Commentary on Nixon's Three Papers Roger Cook 346-347 Commentary on Nixon's From Panexperientialism to Individual Self Conscio…
"Pēteris no Dusburgas. Prūsijas zemes hronika" Tulkojums latviešu valodā no lietuviešu valodas
2003
Tulkojums latviešu valodā no lietuviešu valodas Valdis Salmiņš
ZĪMES anatomija (in Latvian) The Anatomy of ZIME (in English)
2003
Kas ir ZĪME? ZĪME ir datu kopu standartizēta grafiska reprezentācija. ZĪME sastāv no diviem grafiskiem elementiem: (1) Sieta elementa un (2) Koda elementa. Sieta elementu konfigurācija ir nemainīga. Koda elementu konfigurācija mainās saskaņā ar ievadītajiem datiem. The Anatomy of ZIME What is ZIME? ZIME is a standardized graphical representation of data sets. ZIME is built of two graphical elements: (1) Sieve element and (2) Code element. Sieve elements have always the same configuration, while Code elements are configured according to the input data.
HOLLOWS of EXPERIENCE
2010
This essay is divided into two parts, deeply intermingled. Part I examines not only the origin of conscious experience but also how it is possible to ask of our own consciousness how it came to be. Part II examines the origin of experience itself, which soon reveals itself as the ontological question of Being. The chief premise of Part I chapter is that symbolic communion and the categorizations of language have enabled human organisms to distinguish between themselves as actually existing entities and their own immediate experience of themselves and their world. This enables them to reflect upon abstract concepts, including “self,” “experience,” and “world.” Symbolic communication and conc…