Search results for "cb"

Album Fratrum Rigensium

1981

Rubonia, 1875-1925: aus dem Leben eines deutschbaltischen Korps

1925

Album Curonorum: 1808-1932

1932

Vēsture: Latvijas Universitātes Žurnāls, 2 

2016

CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance

2010

The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance and the mechanisms involved in its action. Here, we demonstrate that CB(1) receptors expressed in forebrain and sympathetic neurons play a key role in the pathophysiological development of diet-induced obesity. Conditional mutant mice lacking CB(1) expression in neurons known to control energy balance, but not in nonneuronal peripheral organs, displayed a lean phenotype and res…

TCR V alpha chain expression influences reactivity to the hapten TNP.

1997

We have recently demonstrated a remarkable selection of in vitro cultivated, TNP-specific polyclonal T cell lines for the expression of a TCR beta chain encoded by the V beta 8.2 gene. The goal of the present study was to analyse V alpha usage in V beta 8.2 T cells responsive to TNP, using TNP-specific T cell lines derived from three common strains of mice, as well as from V beta 8.2 transgenic mice. Results indicate that in vitro TNP stimulation of T cells from TNP-immune mice results in significant skewing of V alpha usage among responding V beta 8.2+ T cells, with overexpression observed for V alpha 3.2 and V alpha 8. These results indicate that V alpha expression influences recognition …

Polish military missions in the public perception after 2001

2017

Poland since the beginning of the twenty-first century, and was involved in several military operations of great significance in the political and military for the whole world. The fight against global terrorism in Afghanistan, the implementation of the provisions allied to the US and military involvement in Iraq, the obligation to NATO allied partners from the Baltic countries are just a few of the examples of Polish military involvement on the map of global risks. How to take part in military interventions, military operations and fulfill its alliance commitments approached Polish society? This article is an attempt to approximate public sentiment towards Polish military engagement in the…

Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent syna…

2013

A major goal in current neuroscience is to understand the causal links connecting protein functions, neural activity, and behavior. The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. Studies using conditional knock-out mice revealed necessary roles of CB1 receptor expressed in dorsal telencephalic glutamatergic neurons in synaptic plasticity and behavior, but whether this expression is also sufficient for brain functions is still to be determined. We applied a genetic strategy to reconstitute full wild-type CB1 receptor functions exclusively in dorsal telencephalic glutamatergic neurons a…

On t-Conorm Based Fuzzy (Pseudo)metrics

2020

We present an alternative approach to the concept of a fuzzy (pseudo)metric using t-conorms instead of t-norms and call them t-conorm based fuzzy (pseudo)metrics or just CB-fuzzy (pseudo)metrics. We develop the basics of the theory of CB-fuzzy (pseudo)metrics and compare them with “classic” fuzzy (pseudo)metrics. A method for construction CB-fuzzy (pseudo)metrics from ordinary metrics is elaborated and topology induced by CB-fuzzy (pseudo)metrics is studied. We establish interrelations between CB-fuzzy metrics and modulars, and in the process of this study, a particular role of Hamacher t-(co)norm in the theory of (CB)-fuzzy metrics is revealed. Finally, an intuitionistic version of a CB-fu…

T-cell-mediated cytotoxicity against herpes simplex virus-infected target cells

1977

THE control of herpes simplex virus (HSV) infection by immunological mechanisms seems to be complex and is poorly understood. Neutralising antibodies to HSV plus complement seem to have no effect on the propagation of HSV infection, because HSV spreads to adjacent cells by passing through intercellular bridges1–3. Anti-HSV antibodies plus complement, however, destroy virus-infected cells, but cannot prevent the spread of HSV, suggesting that the virus must be transferred to neighbouring cells before immune lysis occurs1,5. Therefore if lymphocyte-mediated cytolytic mechanisms are instrumental in blocking the spread of HSV in vivo, they ought to destroy infected cells at a very early stage i…