Search results for "cells"

MicroRNAs expression in c-Kit+/Sca-1+/MDR-1+ cardiac stem cells in three dimensional cultures

2011

Role of microRNAs in fetal heart development and in isolated cardiac progenitor cells

2012

ABATEMENT OF ACID ORANGE 7 IN WATER BY DIFFERENT ELECTROCHEMICAL APPROACHES

2014

Very large amounts of synthetic dyes are discharged in the environment from industrial effluents [1]. Due to their large-scale production and extensive application, synthetic dyes can cause considerable nonaesthetic pollution and are serious health-risk factors [2]. Dyes are commonly classified from their chromophore group. The majority of these compounds consumed at industrial scale are azo (–N=N–) derivatives that represent more than 50% of the all dyes used in textile industries, although antraquinone, indigoide, triphenylmethyl, xanthene, sulphur and phtalocyanine derivatives are frequently utilized [3]. Since dyes usually present high stability under sunlight and resistance to microbia…

Mitochondrial proteins regulation in Rattus norvegicus and human cells

2006

Theoretical and experimental study of novel types of solid oxide fuel cell electrodes

2016

Master's thesis Renewable Energy ENE500 - University of Agder 2016 Solid oxide fuel cells (SOFCs) have the potential to become one of the efficient and costeffective system for direct conversion of a wide variety of fuels to electricity. The performance, stability and durability of SOFCs depend strongly on the materials used for the fabrication of electrodes as well as the fabrication process. For anode supported SOFCs, the tape casting method has been the de facto standard for constructing cell components. Furthermore, organic solvents such as ethanol, propanol, terpineol and poly-ethers are generally used in industrial tape casting as the solvent medium to make the chemical slurries out o…

Impact of the Solar Irradiation Angle on the Work of Modules with Spherical Cells - Simulation

2018

The main purpose of all PV modules is to convert solar energy into electricity, but in the era of building integrated photovoltaics, there are additional opportunities to use them. The use of them as a composite of architectural structures in the form of facade cladding, roofing, stained glass windows or noise barriers on highways, in addition to generating electricity embellish also the aesthetic value of the facilities. However, these atypical their use, cause that the modules should have quite different properties then in the traditional application, which is related to their unusual way of positioning. Particularly for structures such as the modules made of spherical cells with the two …

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

2011

International audience; So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes; risk factors associated with RCC include smoking, obesity and hypertension. A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (HIF1A), the pathway of which is targeted by kidney canc…

Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma

2018

Natural killer (NK) cells are innate lymphocytes with a strong antitumor ability. In tumor patients, such as multiple myeloma (MM) patients, an elevated number of NK cells after stem cell transplantation (SCT) has been reported to be correlated with a higher overall survival rate. With the aim of improving NK cell use for adoptive cell therapy, we also addressed the cytotoxicity of patient-derived, cytokine-stimulated NK cells against MM cells at specific time points: at diagnosis and before and after autologous stem cell transplantation. Remarkably, after cytokine stimulation, the patients' NK cells did not significantly differ from those of healthy donors. In a small cohort of MM patients…

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

2019

Abstract Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study is the development of a safe nanotechnology approach for tissue-specific delivery of drugs and diagnostic probes. CD34 + endothelial precursors were addressed in inflamed synovium using targeted biodegradable nanoparticles (tBNPs). These nanostructures were made of poly-lactic acid, poly-caprolactone, and PEG and then coated with a synovi…

Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.

2016

Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. We have investigated the effects of several parathyroid hormone-related protein (PTHrP)-derived peptides (1-37): (N-terminal), (107-111) and (107-139) (C-terminal) on senescence features induced by inflammatory stress in human OA osteoblasts. Incubation of these primary cells with interleukin(IL)-1β led to an increased expression of senescence markers senescence-associated-β-galac…