Search results for "centenari"
showing 10 items of 92 documents
El envejecimiento del envejecimiento: un estudio sobre personas nonagenarias y centenarias en Valencia
2018
Con el aumento del nivel de vida y la mejora de los sistemas de salud no es raro alcanzar edades avanzadas. En la actualidad hay 12.880 personas centenarias en España, de las cuales 558 son supercentenarias (mayores de 110 años) según los datos del INE (2017). La población centenaria en nuestro país supone el 0,04% de la población total. La mayoría de las personas centenarias son mujeres (76,84%) y las supercentenarias también (68,64%). La feminización de la longevidad en España es una realidad. Las proyecciones de población 2016-2066 estiman un crecimiento de las personas mayores de 65 años en España para los próximos años. En la actualidad conforman el 18,7% de la población, para el 2031 …
Transcriptómica en centenarios: un ejemplo de envejecimiento satisfactorio
2021
Los centenarios son un modelo de envejecimiento satisfactorio. No solo disfrutan de una larga longevidad, sino que además muestran una envidiable compresión de la morbilidad. El objetivo del estudio fue esclarecer si las personas centenarias tienen un perfil genético de expresión característico en comparación con personas septuagenarias y jóvenes, así como evaluar sus diferencias a nivel de estrés oxidativo. Para ello se obtuvo muestras de células polimorfonucleares de todos los grupos de edad y se realizó un análisis de su miRNoma y transcriptoma. El análisis de componentes principales reveló un solapamiento entre el perfil de miRNoma de centenarios y el de jóvenes, ambos distintos de los …
Ariosto Redivivus: A Year of Centenary Celebrations and Critical Reassessment
2018
La prima edizione dell’Orlando furioso di Ludovico Ariosto (stampata nel 1516 a Ferrara da Giovanni Mazocco del Bondeno) ha compiuto 500 anni nel 2016. L’articolo ripercorre gli eventi che hanno caratterizzato le celebrazioni, individuando tendenze critiche e suggerendo sviluppi di ricerca. First published in 1516 by Giovanni Mazocco del Bondeno in Ferrara, Ludovico Ariosto’s masterpiece, the Orlando furioso, celebrated its quincentenary in 2016. The article reports on the various events that took place on the occasion, highlighting their scholarly relevance and suggesting new critical developments.
Sicilian semi- and supercentenarians: identification of age-related T cell immunophenotype to define longevity trait
2023
: The immunophenotype of oldest centenarians, i.e., semi- and supercentenarians, could provide important information about their ability to adapt to factors associated with immune changes, including ageing per se and chronic Cytomegalovirus infection. We investigated, by flow cytometry, variations in percentages and absolute numbers of immune cell subsets, focusing on T cells, and pro-inflammatory parameters in a cohort of 28 women and 26 men (age range 19-110 years). We observed variability in hallmarks of immunosenescence related to age and Cytomegalovirus serological status. The eight oldest centenarians showed the lowest percentages of naïve T cells, due to their age, and the highest pe…
The application of genetics approaches to the study of exceptional longevity in humans: Potential and limitations
2012
Abstract The average life-span of the population of industrialized countries has improved enormously over the last decades. Despite evidence pointing to the role of food intake in modulating life-span, exceptional longevity is still considered primarily an inheritable trait, as pointed out by the description of families with centenarian clusters and by the elevated relative probability of siblings of centenarians to become centenarians themselves. However, rather than being two separate concepts, the genetic origin of exceptional longevity and the more recently observed environment-driven increase in the average age of the population could possibly be explained by the same genetic variants …
Centenarians and diet: what they eat in the Western part of Sicily.
2012
Abstract This paper pays attention to the modifiable lifestyle factors such as diet and nutrition that might influence life extension and successful ageing. Previous data reported that in Sicily, the biggest Mediterranean island, there are some places where there is a high frequency of male centenarians with respect to the Italian average. The present data show that in Sicani Mountain zone there are more centenarians with respect to the Italian average. In fact, in five villages of Sicani Mountains, there were 19 people with an age range of 100–107 years old from a total population of 18,328 inhabitants. So, the centenarian number was 4.32-fold higher than the national average (10.37 vs. 2.…
Myocardial Infarction in Centenarians. Data from The Polish Registry of Acute Coronary Syndromes
2020
Background: There are no data regarding the mortality rate, risks and benefits of particular reperfusion methods and pharmacological treatment complications in patients aged over 100 years with acute coronary syndromes. We sought to assess the treatment of myocardial infarction (MI) in patients older than 100 years and to determine prognostic factors for this group. Methods: Among the 716,566 patients recorded between 2003 and 2018 in the Polish Registry of Acute Coronary Syndromes, 104 patients aged &ge
Centenarian offspring: A model for understanding healthy aging
2018
Centenarians exhibit extreme longevity showing a compression of morbidity. We showed previously that microRNA expression profiles and plasma protein carbonylation in centenarians and young people are similar, whereas they are very different from that found in old individuals. This suggests that centenarians have a better control of homeostasis and are protected against oxidative damage. In this study, we aimed to determine if such characteristic microRNA expression profile and lower protein oxidation status in centenarians may be inherited by their offspring. For this purpose, we collected plasma and peripheral blood mononuclear cells from 90 septuagenarians, 68 centenarians and 46 centenar…
Ernesto Basile e l'ampliamento di Palazzo Montecitorio
2018
La vicenda della progettazione della sede definitiva dell’Aula dei Deputati del Parlamento Italiano a Palazzo Montecitorio di Roma copre una stagione nevralgica della cinquantennale attività professionale di Ernesto Basile (Palermo 1857-1932); iniziata con il primo incarico, invero quasi interlocutorio, del 1902 questa stagione si svolge quasi ininterrottamente fino al 1910, quando Basile redige il progetto per la variante definitiva dei prospetti, dopo aver elaborato nel 1908 il progetto esecutivo dell’intera fabbrica dell’ampliamento dell’originario Palazzo Ludovisi a Montecitorio. L’incarico diretto ad Ernesto Basile, oltre ad essere giustificato dalla mancata realizzazione del suo proge…
Conferència "Sanchis Guarner i la secció filològica de l'IEC"
2011
Conferència "Sanchis Guarner i la secció filològica de l'IEC". Homenatge al filòleg Manuel Sanchis Guarner.