Search results for "cern"
showing 10 items of 318 documents
CeRNA and interactome bioinformatic analyses on human telomerase
2014
We present a classic interactome bioinformatic analysis and a study on competing endogenous (ce) RNAs for hTERT. The hTERT gene codes for the catalytic subunit and limiting component of the human telomerase complex. Human telomerase reverse transcriptase (hTERT) is essential for the integrity of telomeres. Telomere dysfunctions have been widely reported to be involved in aging, cancer, and cellular senescence. The hTERT gene network has been analyzed using the BioGRID interaction database (http://thebiogrid.org/) and related analysis tools such as Osprey (http://biodata.mshri.on.ca/osprey/servlet/Index) and GeneMANIA (http://genemania.org/). The network of interaction of hTERT transcripts h…
A Bioinformatics Analysis of Lamin A Regulatory Network: a Perspective on Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome
2011
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ageing and ageing-associated phenotype. HGPS is caused by mutation in the lamin A (LMNA) gene that leads, in affected young individuals, to the generation of progerin, a splicing mutant of lamin A. A bioinformatics analysis of the LMNA gene network of interactions is presented. Lamin A seems to be involved in epigenetic regulation of transcription, chromatin remodelling, DNA repair, with key roles in stemness regulation, normal ageing and telomere functions. The study suggests particular relevance of chromatin remodellers and histones covalent modifiers in the LMNA network. Specifically, HTAT…
Materiali ceramici di importazione africana dalla catacomba di Villagrazia di Carini. Un aggiornamento sulla circolazione nel territorio della eccles…
2012
Primo volume della Collana "Quaderni Digitali di Archeologia Postclassica". La catacomba di Villagrazia di Carini è uno dei principali monumenti del primo Cristianesimo siciliano, cimitero di una comunità agiata e aperta alle relazioni con l'area mediterranea. Lo studio proposto in questo volume, partendo dai dati relativi ai materiali ceramici restituiti dalla stratigrafia archeologica dei settori indagati dal 2000 al 2012, testimonia i rapporti commerciali intercorsi fra il territorio servito dalla presenza del complesso catacombale, coincidente con quello dell'ecclesia carinensis citata da Gregorio Magno, e l'Africa romana e protobizantina.
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.
2013
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…
A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome
2013
Background: Hutchinson-Gilford progeria syndrome is a rare dominant human disease of genetic origin. The average life expectancy is about 20 years, patients’ life quality is still very poor and no efficient therapy has yet been developed. It is caused by mutation of the LMNA gene, which results in accumulation in the nuclear membrane of a particular splicing form of Lamin-A called progerin. The mechanism by which progerin perturbs cellular homeostasis and leads to the symptoms is still under debate. Micro-RNAs are able to negatively regulate transcription by coupling with the 3’ UnTranslated Region of messenger RNAs. Several Micro-RNAs recognize the same 3’ UnTranslated Region and each Micr…
Filozof - przewodnik
2016
Starożytni stoicy uważali siebie za przewodników ludzi w kwestiach dotyczących tego, co zgodne z ich naturą. Udzielali porad, jak postępować w codziennych sprawach. Współcześnie niektórzy filozofowie kontynuują tę starożytną tradycję jako doradcy bądź trenerzy rozwoju osobistego. Czy są przewodnikami w sensie, w jakim byli nimi stoicy? Pytanie to stanie się myślą przewodnią rozważań podjętych w niniejszym wystąpieniu. Problemem podstawowym będzie poszukiwanie właściwej formuły, w jakiej można by było zamknąć współczesne filozoficzne przewodnictwo (kierownictwo duchowe) w sytuacji, gdy uznaje się, że nie może być ono prostym powielaniem starożytnych wzorów
Online Expression, Personal Cybersecurity Costs, and the Specter of Cybercrime
2020
The internet is used increasingly as a platform both for free expression and e-commerce. The internet has unique security and privacy risks. Such risks include the threat of criminal cyberattacks, including hacking and doxing. Internet users have a variety of attitudes towards the security and privacy risks involved with using the internet and distinct concerns and behaviors with regard to expressing themselves online. In order to mitigate the security and privacy risks of the internet, some internet users spend valuable time thinking about and configuring the security settings of their devices. They may also have different attitudes towards personal spending of money for cybersecurity prod…
Estimating QCD uncertainties in Monte Carlo event generators for gamma-ray dark matter searches
2018
Motivated by the recent galactic center gamma-ray excess identified in the Fermi-LAT data, we perform a detailed study of QCD fragmentation uncertainties in the modeling of the energy spectra of gamma-rays from Dark-Matter (DM) annihilation. When Dark-Matter particles annihilate to coloured final states, either directly or via decays such as $W^{(*)}\to q\bar{q}'$, photons are produced from a complex sequence of shower, hadronisation and hadron decays. In phenomenological studies, their energy spectra are typically computed using Monte Carlo event generators. These results have however intrinsic uncertainties due to the specific model used and the choice of model parameters, which are diffi…
Measurements of the top quark branching ratios into channels with leptons and quarks with the ATLAS detector
2015
Measurements of the branching ratios of top quark decays into leptons and jets using events with t[bar over t] (top antitop) pairs are reported. Events were recorded with the ATLAS detector at the LHC in pp collisions at a center-of-mass energy of 7 TeV. The collected data sample corresponds to an integrated luminosity of 4.6 fb[superscript −1]. The measured top quark branching ratios agree with the Standard Model predictions within the measurement uncertainties of a few percent.
Performance of $b$-Jet Identification in the ATLAS Experiment
2016
We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; IN2P3-CNRS, CEA-DSM/IRFU, France; GNSF, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF, I-CORE and Benoziyo Center, Israel; INFN, Italy; MEXT an…