Search results for "challenge"
showing 10 items of 181 documents
A triplet under focus:Innovation, design and the city
2018
Three key concept domains are considered and explored in a unitary framework. They are: innovation, the only possible response to global crises, aiming at transforming behaviours and practices towards systemic changes and transition; design, a way of creatively conceiving, developing and driving forward new practices for undertaking large scale transitions; and cities, seen as the environments where problems present themselves in the most socially relevant way and at the same time as key opportunities for testing and adopting forms of innovation which target global challenges. The chapter positions the three key concepts in relation to the most relevant academic references and to the curren…
Socio-technical innovation in community-based tourism organizations: A proposal for local development
2021
Abstract Socio-technical innovation is based on new patterns of interaction involving a set of new behaviors that have been legitimized in a given context. The approach of socio-technical innovation complements a purely technological innovation focus. However, studies of how to address social and environmental challenges under this approach are scarce. The aim of this paper is to identify the technical and social structures that underpin the socio-technical innovation system of community-based tourism organizations (CBTOs). This paper offers an in-depth case study of a specific type of collective property known as an “ejido”. Through this case study, the paper highlights the aspects that ha…
How can knowledge sharing reduce barriers for entering the Chinese market? : A study on Business Region Kristiansand China Forum
2018
Master's thesis Business Administration BE501 - University of Agder 2018 Konfidensiell til / confidential until 01.07.2023
Analysis of the ATLAS Rome Production Experience on the LHC Computing Grid
2006
The Large Hadron Collider at CERN will start data acquisition in 2007. The ATLAS (A Toroidal LHC Apparatus) experiment is preparing for the data handling and analysis via a series of Data Challenges and production exercises to validate its computing model and to provide useful samples of data for detector and physics studies. The last Data Challenge, begun in June 2004 and ended in early 2005, was the first performed completely in a Grid environment. Immediately afterwards, a new production activity was necessary in order to provide the event samples for the ATLAS physics workshop, taking place in June 2005 in Rome. This exercise offered a unique opportunity to estimate the reached improvem…
School leadership challenges in the implementation of technical and vocational education curriculum in Ghana
2015
Osei-Asibey Daniel. 2015. School Leadership challenges in the Implementation of Technical and Vocational Education Curriculum in Ghana. University of Jyvaskyla. Department of Education. ABSTRACT The purpose of technical and vocational education and training is basically to provide individuals with needed skills for socio-economic and industrial development. In most developing countries especially, TVET lays much emphasis on the kind of training that prepares the youth for self-employment. In Ghana like most developing countries, the aim of TVET is no different from the above. However, TVET in Ghana is bedeviled with a number of challenges ranging from limited funding, inadequate tools and e…
Teachers’ views on differentiation in content and language integrated learning (CLIL): Perceptions, practices and challenges
2012
The present study investigates differentiation in Content and Language Integrated Learning (CLIL) in Finland. Specifically, this combination of a qualitative case study and quantitative survey examines (1) primary teachers’ perceptions of differentiation, (2) the differentiation methods specific to CLIL education the teachers use and (3) the challenges of differentiation they identify. The qualitative phase was conducted in a school which offers CLIL education also to pupils with special needs following the principles of inclusive education. The results revealed that the teachers (n = 51) perceived differentiation in somewhat different ways. In general, the teachers differentiated their CLI…
Prophylaxis of lipopolysaccharide-induced shock by α-galactosylceramide
2008
AbstractThe NKT cell ligand α-galactosylceramide and its synthetic homologue KRN7000 stimulate rapid and copious secretion of IFN-γ and TNF-α release, both of which are key mediators of LPS-induced shock. We showed that KRN7000, injected before or within 2 h after LPS challenge, was able to prevent endotoxic shock. KRN7000 induced survival when the mice were injected 6, 9, or 12 days before the first injection of LPS, and this protective effect was associated with reduction upon subsequent challenge in the levels of IFN-γ, TNF-α, MCP-1, and an increase of IL-10. Further analysis showed that the animals treated with KRN7000 prior to LPS challenge had lower numbers of F4/80+, NKT, and NK cell…
Excretion and measurement of corticosterone and testosterone metabolites in bank voles (Myodes glareolus)
2017
The bank vole is a commonly used model species in behavioral and ecophysiological studies. Thus, presenting a validated method for noninvasive monitoring of corticosterone and testosterone secretion is of high relevance. Here, we evaluated the effect of time of day and an ACTH challenge test on measured fecal corticosterone (FCM) and testosterone (FTM) metabolites in both sexes. Furthermore, we performed radiometabolism experiments for both steroids and sexes to study metabolism and excretion of 3H-corticosterone and 3H-testosterone. FCM and FTM were analysed with a 5α-pregnane-3β,11β,21-triol-20-one enzyme immunoassay (EIA) and a testosterone (measuring 17β-hydroxyandrostanes) EIA, respect…
Sensitization in early age to food allergens in children with atopic dermatitis
2007
Background: Clinical and laboratory evidence increasingly supports the notion that food allergy plays a role in the pathogenesis of atopic dermatitis (AD). However, the prevalence of clinically significant food hypersensitivity among children with AD remains an unanswered question. Objective: To prospectively determine the prevalence of IgE-mediated food hypersensitivity among patients referred to a dermatology department for evaluation of AD, and to analyze the clinical relevance of these sensitizations in AD. Methods: We studied 44 infants of both sexes, aged less than 12 months old, who attended the dermatology department with symptoms of AD. Compliance with Hanifin-Rajka criteria was co…
Evaluation of prostate segmentation algorithms for MRI: The PROMISE12 challenge
2014
Contains fulltext : 137969.pdf (Publisher’s version ) (Open Access) Prostate MRI image segmentation has been an area of intense research due to the increased use of MRI as a modality for the clinical workup of prostate cancer. Segmentation is useful for various tasks, e.g. to accurately localize prostate boundaries for radiotherapy or to initialize multi-modal registration algorithms. In the past, it has been difficult for research groups to evaluate prostate segmentation algorithms on multi-center, multi-vendor and multi-protocol data. Especially because we are dealing with MR images, image appearance, resolution and the presence of artifacts are affected by differences in scanners and/or …